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Effects of ochratoxin A metabolites on yeast phenylalanyl-tRNA synthetase and on the growth and in vivo protein synthesis of hepatoma cells.

Abstract：

:The ochratoxin A (OTA) metabolite (4R)-4-hydroxyochratoxin A [4R)-OTA) inhibits the aminoacylation of phenylalanine tRNA catalyzed by phenylalanyl-tRNA synthetase (PheRS) with a Ki-value of 0.9 mM as compared to 1.3 mM for OTA. It also inhibits protein synthesis and cell growth in the same manner as OTA. Ochratoxin alpha (OT alpha) does not affect either protein synthesis or cell growth.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Creppy EE,Størmer FC,Kern D,Röschenthaler R,Dirheimer G

doi

10.1016/0009-2797(83)90160-6

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

239-47

issue

2

eissn

0009-2797

issn

1872-7786

pii

0009-2797(83)90160-6

journal_volume

47

pub_type

杂志文章

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