Effects of ochratoxin A metabolites on yeast phenylalanyl-tRNA synthetase and on the growth and in vivo protein synthesis of hepatoma cells.

abstract：:The change in the expression of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities in neoplastic colon and lung prompted us to study the possible effect of cancer on the expression of cholinesterases (ChEs) in kidney. Samples of papillary renal cell carcinoma (pRCC), conventional RCC (cRCC), chro...

journal_title：Chemico-biological interactions

authors： Muñoz-Delgado E,Montenegro MF,Morote-García JC,Campoy FJ,Cabezas-Herrera J,Kovacs G,Vidal CJ

更新日期：2008-09-25 00:00:00

abstract：:Chinese hamster ovary (CHO) cells in vitro were treated with HgCl2 at various stages in the cell cycle and the effects of this chemical on cell survival, DNA replication, and cell division were observed. In terms of survival the early G1 cells were the most sensitive to treatment, followed by late G1 and early S, whil...

journal_title：Chemico-biological interactions

authors： Kasschau MR,Elder J,Meyn RE

更新日期：1977-08-01 00:00:00

abstract：:Phenazines, naturally produced by bacteria and archaeal Methanosarcina species are nitrogen-containing tricyclic molecules with antibiotic, antitumoral, and antiparasitic activities. Phenazines are used as electron acceptors-donors in wide range of fields including environmental biosensors. In this study, the inhibito...

journal_title：Chemico-biological interactions

authors： Onder S,Biberoglu K,Tacal O

更新日期：2019-12-01 00:00:00

abstract：:Perinatal development of rat liver nuclear membrane enzymatic activities was investigated with respect to the metabolism of xenobiotica. The qualitative pattern observed was very close to that reported for microsomal enzymes during development. Cytochrome P-450, NADPH-cytochrome c reductase and ethoxycoumarin deethyla...

journal_title：Chemico-biological interactions

authors： Romano M,Clos V,Assael BM,Salmona M

更新日期：1982-11-01 00:00:00

abstract：:Risperidone has been used in some stress disorders and may be potentially protective against stress-induced gastric lesions. Thus, the aim of the present study is to investigate, whether risperidone, a D(2) receptor and 5-HT(2A) receptor antagonist, would be able to result in gastroprotective effect in stress-induced ...

journal_title：Chemico-biological interactions

authors： Saxena B,Krishnamurthy S,Singh S

更新日期：2011-04-25 00:00:00

abstract：:Resveratrol, a polyphenol, found in skin of red grapes, peanuts and berries possesses anti-inflammatory, anti-carcinogenic and lipid modulation properties. Here, we demonstrate in vivo antifibrotic activity of resveratrol in a mammalian model, wherein hepatic fibrosis was induced by N'-nitrosodimethylamine (NDMA) admi...

journal_title：Chemico-biological interactions

authors： Ahmad A,Ahmad R

更新日期：2014-09-25 00:00:00

abstract：:We are investigating treatments for cocaine abuse based on viral gene transfer of a cocaine hydrolase (CocH) derived from human butyrylcholinesterase, which can reduce cocaine-stimulated locomotion and cocaine-primed reinstatement of drug-seeking behavior in rats for many months. Here, in mice, we explored the possibi...

journal_title：Chemico-biological interactions

authors： Brimijoin S,Orson F,Kosten TR,Kinsey B,Shen XY,White SJ,Gao Y

更新日期：2013-03-25 00:00:00

abstract：:Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, we tested the possible use of PEL in the treatment of lipopolysaccharide (LPS)-mediated vascular inflammatory responses. The anti-infla...

journal_title：Chemico-biological interactions

authors： Lee BS,Lee C,Yang S,Park EK,Ku SK,Bae JS

更新日期：2019-04-01 00:00:00

abstract：:Copper, like iron, is an essential transition metal ion in which its redox reactivity, whilst essential for the activity of mitochondrial enzymes, can also be a source of harmful reactive oxygen species if not chelated to biomolecules. Therefore, both metals are sequestered by protein chaperones and moved across membr...

journal_title：Chemico-biological interactions

authors： Mehta R,Templeton DM,O'brien PJ

更新日期：2006-10-27 00:00:00

abstract：:Obesity is characterized by the deposition of excessive body fat, and is caused by energy imbalance, especially when consuming fat-rich diets. High fat diet (HFD)-associated obesity is greatly common in patients with non-alcoholic fatty liver disease (NAFLD) that is emerging as one of the most universal causes of live...

journal_title：Chemico-biological interactions

authors： Lian CY,Zhai ZZ,Li ZF,Wang L

更新日期：2020-10-01 00:00:00

abstract：:Rat hepatic hydroxysteroid sulfotransferase with sulfoconjugates androsterone (androsterone-sulfating sulfotransferase) is an oligomer consisting of several subunits with distinct pI values but with the same molecular mass (pI variants). N-terminal amino acid sequences of the pI variants are all identical. The enzyme ...

journal_title：Chemico-biological interactions

authors： Homma H,Nakagome I,Kamakura M,Hirota M,Takahashi M,Matsui M

更新日期：1994-06-01 00:00:00

abstract：:The objectives of the present work were to study the effects of certain peroxisome proliferators on xenobiotic-metabolizing enzyme activities in the testes of normal and hypothyroid rats, i.e. phenol sulfotransferases (pST), phenol UDP-glucuronosyl transferases (pUDPGT), glutathione transferases (GST), catalase, epoxi...

journal_title：Chemico-biological interactions

authors： Mehrotra K,Morgenstern R,Lundqvist G,Becedas L,Bengtsson Ahlberg M,Georgellis A

更新日期：1997-05-02 00:00:00

abstract：:Acetylcholinesterase (AChE) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. The reversible inhibition of AChE was suggested as the pre-treatment option of the intoxications caused by nerve agents. Based on our derived 3D-QSAR model ...

journal_title：Chemico-biological interactions

authors： Vitorović-Todorović MD,Worek F,Perdih A,Bauk SĐ,Vujatović TB,Cvijetić IN

更新日期：2019-08-25 00:00:00

abstract：:4-methylesculetin (4 ME) is a natural antioxidant coumarin with protective effects on the intestinal inflammation, in which oxidative stress plays a key role in its aetiology and pathophysiology. Based on this, we examined the antioxidant molecular mechanisms involved in the intestinal anti-inflammatory activity of th...

journal_title：Chemico-biological interactions

authors： Tanimoto A,Witaicenis A,Caruso ÍP,Piva HMR,Araujo GC,Moraes FR,Fossey MC,Cornélio ML,Souza FP,Di Stasi LC

更新日期：2020-01-05 00:00:00

abstract：:Tebuconazole (TEB) is a broad-spectrum conazole fungicide that has been used in agriculture in the control of foliar and soil-borne diseases of many crops. The present study has investigated the adverse effects of subchronic exposure to TEB on the kidney of male rats. Animals were divided into four equal groups and tr...

journal_title：Chemico-biological interactions

authors： Othmène YB,Hamdi H,Salem IB,Annabi E,Amara I,Neffati F,Najjar MF,Abid-Essefi S

更新日期：2020-10-01 00:00:00

abstract：:Within the alpha/beta hydrolase fold superfamily of proteins, the COesterase group (carboxylesterase type B, block C, cholinesterases …) diverged from the other groups through simultaneous integration of an N-terminal, first disulfide bond and a significant increase in the protein mean size. This first disulfide bond ...

journal_title：Chemico-biological interactions

authors： Chatonnet A,Brazzolotto X,Hotelier T,Lenfant N,Marchot P,Bourne Y

更新日期：2019-08-01 00:00:00

abstract：:Ayahuasca is a psychoactive concoction prepared from the plants Banisteriopsis caapi and Psychotria viridis which are used ancestrally by Amazonian Indian populations and more recently, by Christian religious groups in Brazil and other countries. The aims of the present study were to identify the effects of ayahuasca ...

journal_title：Chemico-biological interactions

authors： Andrade TS,de Oliveira R,da Silva ML,Von Zuben MV,Grisolia CK,Domingues I,Caldas ED,Pic-Taylor A

更新日期：2018-09-25 00:00:00

abstract：:10-(2-pyrazolyl-ethoxy)-(20S)-camptothecin (CPT13) is a novel semi-synthetic analogue of camptothecin, our previous report had shown that it possessed higher in vitro cytoxicity activity towards human colon cancer HCT8 cell line than topotecan. In this study, the anti-proliferative effect of CPT13 on HCT8 cell line in...

journal_title：Chemico-biological interactions

authors： Wang LM,Li QY,Zu YG,Fu YJ,Chen LY,Lv HY,Yao LP,Jiang SG

更新日期：2008-11-25 00:00:00

abstract：:The mutagenicity of many 2-aminoimidazole-azaarenes (AIA) is thought to be mediated by the nitrenium form of the exocyclic amine. This hypothesis is supported by the numerous correlations found between calculated and experimentally-measured chemical properties for the nitreniums and the mutagenic potencies of the nitr...

journal_title：Chemico-biological interactions

authors： Colvin ME,Seidl ET,Nielsen IM,Le Bui L,Hatch FT

更新日期：1997-12-12 00:00:00

abstract：:The clinical use of doxorubicin is associated with dose limiting cardiotoxicity. This is a manifestation of free radical production triggered by doxorubicin. Therefore, we evaluated the efficacy of febuxostat, a xanthine oxidase inhibitor and antioxidant, in blocking cardiotoxicity associated with doxorubicin in rats....

journal_title：Chemico-biological interactions

authors： Krishnamurthy B,Rani N,Bharti S,Golechha M,Bhatia J,Nag TC,Ray R,Arava S,Arya DS

更新日期：2015-07-25 00:00:00

abstract：:4-Methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) has been identified as one of the strongest nitrosamine carcinogens in tobacco products in all species tested. Carbonyl reduction to 4-methylnitrosamino-1-(3-pyridyl)-1-butanol (NNAL) followed by glucuronosylation is considered to be the main detoxification pathway in...

journal_title：Chemico-biological interactions

authors： Atalla A,Maser E

更新日期：2001-01-30 00:00:00

abstract：:A facile method was developed to covalently attach a fluorophore to the 5'-phosphate of a nucleic acid. The procedure, illustrated by coupling 5'-dNmp (N = A,C,G,T) with 5-dimethylaminonaphthalene 1-sulfonyl chloride, commonly known as Dansyl chloride, involves 5'-phosphoramidation with ethylenediamine (EDA) followed ...

journal_title：Chemico-biological interactions

authors： Kelman DJ,Lilga KT,Sharma M

更新日期：1988-01-01 00:00:00

abstract：:A single dose of the carcinogen aflatoxin B1 (7 mg/kg body weight) to male Wistar rats significantly enhanced the hepatic activity of protein kinase C in the particulate and nuclear fractions. The particulate fraction showed stimulation at 4 and 7 h, while the nuclear activity was increased at 17 h following administr...

journal_title：Chemico-biological interactions

authors： Mistry KJ,Krishna M,Pasupathy K,Murthy V,Bhattacharya RK

更新日期：1996-03-25 00:00:00

abstract：:The in vitro metabolism of p-nitroanisole, aminopyrine, and aniline by rat liver microsomal monoxygenases were studied in the presence of different polychlorinated biphenyl (PCB) mixtures and some related hydroxybiphenyls. The tested PCB mixtures contained preferably dichloro- (di-CB), tetrachloro- (tetra-CB), or hexa...

journal_title：Chemico-biological interactions

authors： Schmoldt A,Herzberg W,Benthe HF

更新日期：1977-02-01 00:00:00

abstract：:Cisplatin induces acute renal failure in humans and mice.Tubular apoptosis, necrosis and inflammation are the primary pathogenesis of cisplatin-induced acute kidney injury(AKI). We previously reported that the depletion of Numb from proximal tubules exacerbates tubular cells apoptosis in cisplatin-induced AKI, however...

journal_title：Chemico-biological interactions

authors： Liu Z,Li Z,Chen Z,Li C,Lei L,Wu X,Li Y

更新日期：2020-10-01 00:00:00

abstract：:Copper is an essential trace metal for physiological functions, whereas copper overload causes cytotoxicity in living organisms. Genetically determined systems regulate acquisition, distribution and storage for copper maintenance and homeostasis. The Human ATP7A copper transport ATPase modulates intracellular copper d...

journal_title：Chemico-biological interactions

authors： Chen HR,Yang HC,Hsieh DJ,Liu Z,Tsai KJ

更新日期：2011-02-01 00:00:00

abstract：:It has been suggested that the binding of iron(III) by phosvitin involves the phosphoric radicals of phosphorylserine residues, many of which are arranged in rows of several consecutive phosphoamino acids. In this paper we present evident that, unlike free phosphorylserine which does not interact with Fe(III), polypho...

journal_title：Chemico-biological interactions

authors： Donella A,Pinna LA,Moret V

更新日期：1976-10-02 00:00:00

abstract：:N-Hydroxyethylnitroso-N'-ethylurea (HEENU) and N-hydroxyethylnitroso-N'-chloroethylurea (HCNU) are two of the few nitrosoureas which induce hepatocellular tumours in rats without further treatment. In the present study we have investigated whether this is due to selectively elevated levels of DNA hydroxyethylation in ...

journal_title：Chemico-biological interactions

authors： Ludeke B,Schubert M,Yamada Y,Lijinsky W,Kleihues P

更新日期：1991-01-01 00:00:00

abstract：:The influence of systemic application of chemically unrelated drugs and xenobiotics (phenobarbital (PB), rifampicin (Rifa), pregnenolone-16 alpha-carbonitrile (PCN) and 3-methylcholanthrene (MC) on drug metabolizing enzymes was investigated in the skin of rats of both sexes. The results were compared with those obtain...

journal_title：Chemico-biological interactions

authors： Vizethum W,Ruzicka T,Goerz G

更新日期：1980-08-01 00:00:00

abstract：:Since endogenous glutathione (GSH), the main non-protein intracellular thiol compound, is known to provide protection against reactive radical species, its depletion by diethylmaleate (DEM) was used to assess the role of free radical formation mediated by doxorubicin in DNA damage, cytotoxicity and mutagenicity of the...

journal_title：Chemico-biological interactions

authors： Capranico G,Babudri N,Casciarri G,Dolzani L,Gambetta RA,Longoni E,Pani B,Soranzo C,Zunino F

更新日期：1986-02-01 00:00:00