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Exposure to ayahuasca induces developmental and behavioral alterations on early life stages of zebrafish.

Abstract：

:Ayahuasca is a psychoactive concoction prepared from the plants Banisteriopsis caapi and Psychotria viridis which are used ancestrally by Amazonian Indian populations and more recently, by Christian religious groups in Brazil and other countries. The aims of the present study were to identify the effects of ayahuasca on zebrafish embryo development and neurobehavior. Toxicity and developmental endpoints for zebrafish embryos were assessed from 0 to 1000 mg/L over 96 h of exposure. The effects on locomotor activity of zebrafish larvae were assessed using a video tracking system (ZebraBox) from 0 to 20 mg/L and after 120 and 144 h of exposure. The LC50 of ayahuasca in zebrafish was determined as 236.3 mg/L. Ayahuasca exposure caused significant developmental anomalies in zebrafish embryos, mainly at the highest concentration tested, including hatching delay, loss of equilibrium, edema and the accumulation of red blood cells. Embryo behavior was also significantly affected, with decreased locomotor activity at the highest concentration tested. These results are in accordance with data obtained in mammal studies highlighting the possible risks of uncontrolled use of ayahuasca. Further research employing more specific behavior analysis could provide additional data on both therapeutic benefits and possible toxicological risk of ayahuasca.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Andrade TS,de Oliveira R,da Silva ML,Von Zuben MV,Grisolia CK,Domingues I,Caldas ED,Pic-Taylor A

doi

10.1016/j.cbi.2018.08.001

subject

Has Abstract

pub_date

2018-09-25 00:00:00

pages

133-140

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(18)30615-X

journal_volume

293

pub_type

杂志文章

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