Quinone imine-induced Ca2+ release from isolated rat liver mitochondria.

Abstract:

:Incubation of Ca2(+)-loaded rat liver mitochondria with N-acetyl-p-benzoquinone imine (NAPQI) or its two dimethylated analogues resulted in a concentration dependent Ca2+ release, with the following order of potency: 2,6-(Me)2-NAPQI greater than NAPQI greater than 3,5-(Me)2-NAPQI. The quinone imine-induced Ca2+ release was associated with NAD(P)H oxidation and was prevented when NAD(P)+ reduction was stimulated by the addition of 3-hydroxybutyrate. Mitochondrial glutathione was completely depleted within 0.5 min by all three quinone imines, even at low concentrations that did not result in Ca2+ release. Depletion of mitochondrial GSH by pretreatment with 1-chloro-2,4-dinitrobenzene enhanced quinone imine-induced NAD(P)H oxidation and Ca2+ release. However, 3-hydroxybutyrate protected from quinone imine-induced Ca2+ release in GSH-depleted mitochondria. Mitochondrial membrane potential was lost after the addition of quinone imines at concentrations that caused rapid Ca2+ release; however, subsequent addition of EGTA led to the complete recovery of the transmembrane potential. In the absence of Ca2+, the quinone imines caused only a small and transient loss of the transmembrane potential. Taken together, our results suggests that the quinone imine-induced Ca2+ release from mitochondria is a consequence of NAD(P)H oxidation rather than GSH depletion, GSSG formation, or mitochondrial inner membrane damage.

journal_name

Chem Biol Interact

authors

Weis M,Moore GA,Cotgreave IA,Nelson SD,Moldeus P

doi

10.1016/0009-2797(90)90090-a

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

227-40

issue

2

eissn

0009-2797

issn

1872-7786

pii

0009-2797(90)90090-A

journal_volume

76

pub_type

杂志文章
  • Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase.

    abstract::Butyrylcholinesterase (BChE) has proven to be an effective bioscavenger against nerve agents and organophosphates. Phase I safety trials of human BChE are currently being conducted and large-scale production of recombinant BChE is underway. Information on the real-time distribution of BChE from the injection site has ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2008.02.011

    authors: Duysen EG,Lockridge O

    更新日期:2008-09-25 00:00:00

  • Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity.

    abstract::Fatty liver is the hepatic consequence of chronic insulin resistance (IR) and related syndromes. It is mostly accompanied by inflammatory and oxidative molecules. Increased activity of xanthine oxidase (XO) exerts both inflammatory and oxidative effects and has been implicated in metabolic derangements including non-a...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2019.108929

    authors: Dangana EO,Omolekulo TE,Areola ED,Olaniyi KS,Soladoye AO,Olatunji LA

    更新日期:2020-01-25 00:00:00

  • LC-MS based metabolomics reveals metabolic pathway disturbance in retinal pigment epithelial cells exposed to hydroxychloroquine.

    abstract::Hydroxychloroquine (HCQ) is frequently used medications for many auto-immunity diseases. However, HCQ induced retinal toxicity, which might result in irreversible retinopathy, is one of the most important complications of HCQ. However, the molecular mechanism underlying the HCQ retinal toxicity is still not well known...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2020.109212

    authors: Li JH,Xu ZY,Li MJ,Zheng WL,Huang XM,Xiao F,Cui YH,Pan HW

    更新日期:2020-09-01 00:00:00

  • Effect of procaine hydrochloride on DNA repair in Escherichia coli.

    abstract::Liquid-holding recovery and rejoining of gamma-radiation-induced DNA single-strand scissions in Escherichia coli could be effectively inhibited by procaine hydrochloride at the concentration of 20 mM. At this concentration, the drug also reversibly altered cellular permeability barrier as evidenced from the uptake of ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(75)90097-6

    authors: Nair CK,Pradhan DS

    更新日期:1975-09-01 00:00:00

  • Mangiferin attenuates blast-induced traumatic brain injury via inhibiting NLRP3 inflammasome.

    abstract::There is growing evidence that Mangiferin possess therapeutic benefit during neuroinflammation on various brain injury models due to its anti-inflammatory properties. It is reported that inflammatory plays a crucial role in the pathogenesis of secondary injury induced by the blast-induced traumatic brain injury (bTBI)...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2017.04.021

    authors: Fan K,Ma J,Xiao W,Chen J,Wu J,Ren J,Hou J,Hu Y,Gu J,Yu B

    更新日期:2017-06-01 00:00:00

  • Single immunoglobulin IL-1 receptor-related protein attenuates the lipopolysaccharide-induced inflammatory response in A549 cells.

    abstract::The lipopolysaccharide (LPS)-Toll-like receptor 4 (TLR4) signaling pathway in alveolar epithelial cells plays an important role in many pathologic processes such as acute lung injury (ALI). The single immunoglobulin IL-1 receptor-related protein (SIGIRR) is an inhibitor of LPS-TLR4 signaling, but its expression and fu...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2009.11.022

    authors: Feng T,Yunfeng N,Jinbo Z,Zhipei Z,Huizhong Z,Li L,Tao J,Yunjie W

    更新日期:2010-02-12 00:00:00

  • In vitro and in vivo anticancer activity of posterior salivary gland toxin from the cuttlefish Sepia pharaonis, Ehrenberg (1831).

    abstract::Posterior salivary gland (PSG) toxins are high molecular weight toxins secreted by cephalopods and gastropods which possess immense potentials in biomedical applications. In the present study, the biomedical potentials of the PSG toxin from the cuttlefish, S. pharaonis was determined in vitro and in vivo. The cytostat...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2017.04.002

    authors: Karthik R,Manigandan V,Ebenezar KK,Vijayashree R,Saravanan R

    更新日期:2017-06-25 00:00:00

  • A novel fused 1,2,4-triazine aryl derivative as antioxidant and nonselective antagonist of adenosine A(2A) receptors in ethanol-activated liver stellate cells.

    abstract::It has been detected that hepatic adenosine A(2A) receptors play an active role in the pathogenesis of hepatic fibrosis and suggest a novel therapeutic target in the treatment and prevention of hepatic cirrhosis. In this paper we examined if our new triazine derivative (IMT) can inhibit ethanol-induced activation of H...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2011.10.004

    authors: Szuster-Ciesielska A,Sztanke K,Kandefer-Szerszeń M

    更新日期:2012-01-05 00:00:00

  • The alkaloid, soyauxinium chloride, displays remarkable cytotoxic effects towards a panel of cancer cells, inducing apoptosis, ferroptosis and necroptosis.

    abstract::The cytotoxic potential of a naturally occurring indoloquinazoline alkaloid, soyauxinium chloride (SCHL), was determined on a broad panel of animal and human cancer cell lines, including various sensitive and drug-resistant phenotypes. The cytotoxicity, SCHL-induced autophagic, ferroptotic, and necroptotic cell death ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2020.109334

    authors: Mbaveng AT,Noulala CGT,Samba ARM,Tankeo SB,Abdelfatah S,Fotso GW,Happi EN,Ngadjui BT,Beng VP,Kuete V,Efferth T

    更新日期:2021-01-05 00:00:00

  • Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2.

    abstract::Myristicin belongs to the methylenedioxyphenyl or allyl-benzene family of compounds, which are found widely in plants of the Umbelliferae family, such as parsley and carrot. Myristicin is also the major active component in the essential oils of mace and nutmeg. However, this compound can cause adverse reactions, parti...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2015.06.018

    authors: Yang AH,He X,Chen JX,He LN,Jin CH,Wang LL,Zhang FL,An LJ

    更新日期:2015-07-25 00:00:00

  • Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.

    abstract::Adverse drug reactions (ADRs) remain a major complication of drug therapy and can be classified as 'on-target' or 'off-target' (idiosyncratic) reactions. On-target reactions can be predicted from the known primary or secondary pharmacology of the drug and often represent an exaggeration of the pharmacological effect o...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2010.09.011

    authors: Park BK,Laverty H,Srivastava A,Antoine DJ,Naisbitt D,Williams DP

    更新日期:2011-06-30 00:00:00

  • In vitro studies of the genotoxic effects of bitumen and coal-tar fume condensates: comparison of data obtained by mutagenicity testing and DNA adduct analysis by 32P-postlabelling.

    abstract::Bitumens contain traces of polycyclic aromatic compounds (PACs), a part of which will end up in the fumes emitted during hot handling of bitumen-containing products, e.g. during roadpaving. Although exposure of workers to these fumes is low, it might lead to health problems. Studies on bitumen fume condensates (BFCs) ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(96)03705-2

    authors: De Méo M,Genevois C,Brandt H,Laget M,Bartsch H,Castegnaro M

    更新日期:1996-08-14 00:00:00

  • Role of intracellular reactive oxygen species and mitochondrial dysfunction in evening primrose extract-induced apoptosis in Ehrlich ascites tumor cells.

    abstract::Herbal medicines are increasingly being utilized to treat a wide variety of disease processes. Evening primrose extract (EPE) is extracted from Oenothera biennis L., one species of evening primroses, which has been shown to have several pharmacological effects. However, anti-tumor activity in the extract of defatted s...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/s0009-2797(03)00060-7

    authors: Arimura T,Kojima-Yuasa A,Watanabe S,Suzuki M,Kennedy DO,Matsui-Yuasa I

    更新日期:2003-06-15 00:00:00

  • Interactions between microbiome and lungs: Paving new paths for microbiome based bio-engineered drug delivery systems in chronic respiratory diseases.

    abstract:BACKGROUND:The human body is a home to thousands of microbiotas. It is defined as a community of symbiotic, commensal and pathogenic microorganisms that have existed in all exposed sites of the body, which have co-evolved with diet, lifestyle, genetic factors and immune factors. Human microbiotas have been studied for ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbi.2019.108732

    authors: Chellappan DK,Sze Ning QL,Su Min SK,Bin SY,Chern PJ,Shi TP,Ee Mei SW,Yee TH,Qi OJ,Thangavelu L,Rajeshkumar S,Negi P,Chellian J,Wadhwa R,Gupta G,Collet T,Hansbro PM,Dua K

    更新日期:2019-09-01 00:00:00

  • Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes.

    abstract::Damage of cell membranes by reactive oxygen species results in the formation of toxic lipid peroxides which may ultimately lead to cell death. Among the best characterized intermediates of oxidative stress are the unsaturated aldehydes 4-hydroxynon-2-enal (4-HNE) and its oxidized counterpart 4-oxonon-2-enal (4-ONE). 4...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2008.10.021

    authors: Martin HJ,Maser E

    更新日期:2009-03-16 00:00:00

  • PXR: Structure-specific activation by hepatotoxic pyrrolizidine alkaloids.

    abstract::Pyrrolizidine alkaloids (PAs) comprise a large group of more than 660 secondary metabolites found in more than 6000 plant species worldwide. Acute PA intoxication induces severe liver damage. Chronic exposure to sub-lethal doses may cause cumulative damage or cancer. Nuclear receptor activation often constitutes a mol...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2018.04.017

    authors: Luckert C,Braeuning A,Lampen A,Hessel-Pras S

    更新日期:2018-05-25 00:00:00

  • Antiproliferative activity and interactions with cell-cycle related proteins of the organotin compound triethyltin(IV)lupinylsulfide hydrochloride.

    abstract::Organotin compounds, particularly tri-organotin, have demonstrated cytotoxic properties against a number of tumor cell lines. On this basis, triethyltin(IV)lupinylsulfide hydrochloride (IST-FS 29), a quinolizidine derivative, was synthesized and developed as a potential antitumor agent. This tin-derived compound exhib...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/s0009-2797(00)00249-0

    authors: Barbieri F,Sparatore F,Cagnoli M,Bruzzo C,Novelli F,Alama A

    更新日期:2001-03-14 00:00:00

  • Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes.

    abstract::Numerous reactive oxygen species (ROS) and reactive carbonyl species (RCS) issuing from lipid and sugar oxidation are known to damage a large number of proteins leading to enzyme inhibition and alteration of cellular functions. Whereas studies in literature only focus on the reactivity of one or two of these compounds...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2010.12.028

    authors: Lesgards JF,Gauthier C,Iovanna J,Vidal N,Dolla A,Stocker P

    更新日期:2011-03-15 00:00:00

  • Impact of exogenous lysolipids on sensitive and multidrug resistant K562 cells: 1H NMR studies.

    abstract::The ability of lysolipids to enter into a membrane bi-layer and disturb the membrane structure was used to study the behavior of K562 erythroleukemic cells, K562 wild type (K562wt) as well as the multidrug resistant cells K562adr. Both types of cells, when analyzed by proton NMR spectroscopy exhibit the high resolutio...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2004.12.005

    authors: Traïkia M,Marbeuf-Gueye C,Hantz E,Le Moyec L

    更新日期:2005-01-15 00:00:00

  • Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor.

    abstract::It has been postulated that reversible, high-affinity binding of 3-methylcholanthrene(MC)-type inducers to a receptor protein (the Ah receptor) in hepatic cytosol is essential for induction of aryl hydrocarbon hydroxylase (AHH) enzymic activity. To test this postulate, the binding affinities of 16 highly-purified, syn...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(82)90045-x

    authors: Bandiera S,Safe S,Okey AB

    更新日期:1982-04-01 00:00:00

  • Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity.

    abstract::Reactive metabolites formed from benzene include benzene oxide, trans,trans muconaldehyde, quinones, thiol adducts, phenolic metabolites and oxygen radicals. Susceptibility to the toxic effects of benzene has been suggested to occur partly because of polymorphisms in enzymes involved in benzene metabolism which includ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2009.11.017

    authors: Ross D,Zhou H

    更新日期:2010-03-19 00:00:00

  • Dysregulation of UDP-glucuronosyltransferases in CCl4 induced liver injury rats.

    abstract::UDP-glucuronosyltransferases (UGTs) are a family of phase II drug metabolizing enzymes that catalyze glucuronidation of numerous endogenous and exogenous substrates. Carbon tetrachloride (CCl4) is widely used to develop liver injuries mimicking human liver diseases. However, effects of CCl4 on the expression and activ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2020.109115

    authors: Xu L,Zheng R,Xie P,Guo Q,Ji H,Li T

    更新日期:2020-07-01 00:00:00

  • Arsenic, cadmium, mercury and nickel stimulate cell growth via NADPH oxidase activation.

    abstract::Exposure to metals and metalloids including arsenic, cadmium, mercury, and nickel has been a worldwide health problem for several decades. The aim of this study was to learn how metal-induced oxidative stress triggers cell proliferation, a process of great significance for cancer. NADPH oxidase (NOX) activity and cell...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2014.10.034

    authors: Mohammadi-Bardbori A,Rannug A

    更新日期:2014-12-05 00:00:00

  • Involvement of PI3K/Akt/GSK-3β signaling pathway in the antidepressant-like and neuroprotective effects of Morus nigra and its major phenolic, syringic acid.

    abstract::Depression is a common neuropsychiatric disorder whose pathophysiology has been associated with glutamatergic excitotoxicity. Thus, the research for new antidepressant strategies with the ability to mitigate glutamate toxicity has received growing attention. Given this background, the present study sought to investiga...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2019.108843

    authors: Dalmagro AP,Camargo A,Severo Rodrigues AL,Zeni ALB

    更新日期:2019-12-01 00:00:00

  • Aliskiren - A promising antioxidant agent beyond hypertension reduction.

    abstract::The renin-angiotensin-aldosterone system (RAAS) is a hormonal system that has a critical role in maintaining the normotensive state and electrolyte balance of the organism. The RAAS also has an important influence in the development of various pathophysiological conditions especially those concerning the renal system,...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbi.2020.109145

    authors: Alshahrani S

    更新日期:2020-08-01 00:00:00

  • Interaction of benzo [A] pyrene and a hyperplastic agent in epidermal nuclear enlargement in the mouse. A dose response study.

    abstract::Experiments were conducted on the effects of various dose levels of benzo [a]pyrene (BP) on nuclear size in mouse interfollicular epidermis over a 3-day period. Topical application of BP was made with or without croton oil (CO) (0.1 or 0.5%) in the vehicles acetone, toluene and methyl ethyl ketone (MEK). Nuclear size ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(79)90096-6

    authors: Ingram AJ

    更新日期:1979-06-01 00:00:00

  • Human erythrocyte hemolysis induced by selenium and tellurium compounds increased by GSH or glucose: a possible involvement of reactive oxygen species.

    abstract::Oxidative stress can induce complex alterations of membrane proteins in red blood cells (RBCs) eventually leading to hemolysis. RBCs represent a good model to investigate the damage induced by oxidizing agents. Literature data have reported that chalcogen compounds can present pro-oxidant properties with potent inhibi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2008.10.007

    authors: Schiar VP,Dos Santos DB,Paixão MW,Nogueira CW,Rocha JB,Zeni G

    更新日期:2009-01-15 00:00:00

  • The effect of 5-iodouracil on the growth and biosynthetic processes of bacteriophage T4td8 in the absence of light.

    abstract::5-Iodouracil (IUra)-substituted progeny bacteriophage T4td8 were grown under conditions such that, upon CsCl equilibrium isopycnic gradient centrifugation, progeny with density distributions about the median similar to that of unsubstituted phage are obtained. In the absence of light a monotonic relationship exists be...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(76)90099-5

    authors: Byrd DM,Prusoff WH

    更新日期:1976-02-01 00:00:00

  • Synergistic effects of anethole and ibuprofen in acute inflammatory response.

    abstract::This study assessed the effect of the combination of anethole and ibuprofen in comparison with monotherapy by either drug alone, using two in vivo inflammatory models, namely the pleurisy and paw edema in rats. We also measured the levels of the TNF protein in plasma, and the ability of anethole to inhibit, in vitro, ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2015.10.013

    authors: Wisniewski-Rebecca ES,Rocha BA,Wiirzler LA,Cuman RK,Velazquez-Martinez CA,Bersani-Amado CA

    更新日期:2015-12-05 00:00:00

  • DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalation.

    abstract::Genotoxic and clastogenic effects of styrene were studied in mice. Male NMRI mice were exposed by inhalation to styrene in concentrations of 750 and 1500 mg/m3 for 21, 7, 3 and 1 days (6 h/day, 7 days/week). Followed parameters included styrene in blood, specific styrene oxide (SO) induced DNA adducts, DNA strand brea...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/s0009-2797(01)00253-8

    authors: Vodicka P,Koskinen M,Vodicková L,Stetina R,Smerák P,Bárta I,Hemminki K

    更新日期:2001-09-28 00:00:00