Astaxanthin improves serum cytokine expression and semen quality of diabetes mellitus KKAy mice.

abstract：:Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus (DM) that worsens its morbidity and mortality. There is evidence that camel milk (CM) improves the glycemic control in DM but its effect on the renal complications especially the DN remains unclear. Thus the current study aimed to ch...

journal_title：Chemico-biological interactions

authors： Korish AA,Abdel Gader AG,Korashy HM,Al-Drees AM,Alhaider AA,Arafah MM

更新日期：2015-03-05 00:00:00

abstract：:Methylmercury is a widely distributed environmental toxicant with detrimental effects on the developing and adult nervous system. Due to its accumulation in the food chain, chronic exposure to methylmercury via consumption of fish and sea mammals is still a major concern for human health, especially developmental expo...

journal_title：Chemico-biological interactions

authors： Ceccatelli S,Daré E,Moors M

更新日期：2010-11-05 00:00:00

abstract：:The asymmetric A12 acetylcholinesterase (AChE) molecular form, consisting of three tetrameric catalytic oligomers and three non-catalytic subunits of collagen Q (ColQ), is the functional AChE form in the neuromuscular junction. Its extremely high concentration and sharp localization in the junction is mostly due to th...

journal_title：Chemico-biological interactions

authors： Crne-Finderle N,Pregelj P,Sketelj J

更新日期：2005-12-15 00:00:00

abstract：:Increasing evidence has shown that dysregulation of microRNA-621 (miR-621) is demonstrated to be associated with several cancers. However, the role of miR-621 in bladder cancer (BCa) remains unclear. Herein, we aimed to study the expression pattern, biological function, and molecular mechanism of miR-621 in BCa. First...

journal_title：Chemico-biological interactions

authors： Tian H,Wang X,Lu J,Tian W,Chen P

更新日期：2019-08-01 00:00:00

abstract：:A single intravenous injection of methylazoxymethanol (MAM) acetate in doses of either 20 or 35 mg/kg body weight to male Sprague-Dawley rats induced altered liver cell foci and later, liver neoplasms in a dose related manner. Sequential observations in the rats given 35 mg/kg and thereafter fed an iron-loading diet r...

journal_title：Chemico-biological interactions

authors： Tanaka T,Mori H,Hirota N,Furuya K,Williams GM

更新日期：1986-04-01 00:00:00

abstract：:The reactive oxygen species (ROS) induced oxidative stress is an inevitable factor for the pathogenesis of cardiovascular diseases. The edible marine algae-derived sulfated polysaccharides gained special attention as novel bioactive compounds having potential pharmacological activities. The present study evaluated in ...

journal_title：Chemico-biological interactions

authors： V S L,Rauf AA,Kurup GM

更新日期：2019-08-01 00:00:00

abstract：:Using a rat liver cytosol source of enzyme trialkyl phosphorothioates have been shown to be substrates of glutathione S-transferases. Using OSS-trimethyl phosphorodithioate (OSS-Me(O] and OOS-trimethyl phosphorothioate (OOS-Me(O] the methyl transferred to the sulphydryl of glutathione is that attached to phosphorus vi...

journal_title：Chemico-biological interactions

authors： Aldridge WN,Grasdalen H,Aarstad K,Street BW,Norkov T

更新日期：1985-07-01 00:00:00

abstract：:Little is known about the roles of aldehyde dehydrogenases in non-vertebrate animals. We recently showed that in Drosophila melanogaster, an enzyme with ∼70% amino acid identity to mammalian ALDH2 is necessary for detoxification of dietary ethanol. To investigate other functions of this enzyme, DmALDH, encoded by the ...

journal_title：Chemico-biological interactions

authors： Chakraborty M,Fry JD

更新日期：2011-05-30 00:00:00

abstract：:Two types of cholinesterases (ChEs) are present in mammalian blood and tissues: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE regulates neurotransmission by hydrolyzing acetylcholine at the postsynaptic membranes and neuromuscular junctions, BChE in plasma has been suggested to be involved i...

journal_title：Chemico-biological interactions

authors： Naik RS,Belinskaya T,Vinayaka CR,Saxena A

更新日期：2020-10-01 00:00:00

abstract：:Flavonls are natural compounds present in edible plants and possess several biological activities that can be useful in drug design. Conversely some of these compounds have been shown to be genotoxic to prokaryotic and eukaryotic cells. In this study we tried to establish the chemical features responsible for the geno...

journal_title：Chemico-biological interactions

authors： Silva ID,Gaspar J,da Costa GG,Rodrigues AS,Laires A,Rueff J

更新日期：2000-01-03 00:00:00

abstract：:2,4,6-Triphenyldioxane-1,3 (TPD) is a highly effective species-specific inducer of CYP2В in rats. Several analogs of TPD were synthesized to verify a hypothesis that minor changes in the inducer structure can cause changes in induction abilities (R=H, cisTPD and transTPD; R=N(CH(3))(2), transpDMA; R=NO(2), transpNO(2)...

journal_title：Chemico-biological interactions

authors： Pustylnyak V,Yarushkin A,Kachaylo E,Slynko N,Lyakhovich V,Gulyaeva L

更新日期：2011-07-15 00:00:00

abstract：:Uptake of Hg2+ into the renal and hepatic metallothioneins of rats is increased by pretreatment with Cd2+. This increased uptake occurs both by displacement of Cd2+ (and of Zn2+) from the presynthesized cadmium-thionein, and by further synthesis of thionein. The former mechanism predominates in the kidney of the male ...

journal_title：Chemico-biological interactions

authors： Webb M,Magos L

更新日期：1976-08-01 00:00:00

abstract：:Cytochrome P450 (CYP), a superfamily of hepatic monooxygenase enzymes, catalyzes biotransformation of endogenous compounds and xenobiotics. Modification of CYPs associated with metabolic diseases and continuous consumption of diet with excessive energy levels. Tetrahydrocurcumin (THC) exhibited beneficial effects in m...

journal_title：Chemico-biological interactions

authors： Jearapong N,Chatuphonprasert W,Jarukamjorn K

更新日期：2015-09-05 00:00:00

abstract：:A chromatographic procedure for improved separation of deoxyribonucleosides and methylated deoxyribonucleosides is described. DNA was isolated from liver and small intestine of rats treated with [14C]dimethylnitrosamine ([14C]DMN) or N-[3H]methyl-N-nitrosourea ([3H]MNU), and the purified DNA was hydrolyzed enzymatical...

journal_title：Chemico-biological interactions

authors： Daoud AH,Irving CC

更新日期：1977-02-01 00:00:00

abstract：:Styrene oxide was reacted with deoxynucleosides and DNA in aqueous buffer at pH 7.4. The products were purified by HPLC, characterized by UV spectroscopy and by chemical ionization mass spectrometry. The main products identified were 7-alkyl-, N2-alkyl- and O6-alkyldeoxyguanosine, 1-alkyl-, and N6-alkyldeoxyadenosine,...

journal_title：Chemico-biological interactions

authors： Savela K,Hesso A,Hemminki K

更新日期：1986-12-01 00:00:00

abstract：:Two new flavonoids, bismilachinone (11) and smilachinin (14), were isolated from the leaves of Smilax china L. together with 14 known compounds. Their structures were elucidated using spectroscopic methods. The PTP1B, α-glucosidase, and DPP-IV inhibitory activities of compounds 1-16 were evaluated at the molecular lev...

journal_title：Chemico-biological interactions

authors： Zhao BT,Le DD,Nguyen PH,Ali MY,Choi JS,Min BS,Shin HM,Rhee HI,Woo MH

更新日期：2016-06-25 00:00:00

abstract：:Keeping in mind the vasodilator action of prostaglandins, the control that they exercise over the vascular supply of kidneys and the sympathetic activity, research was conducted in order to establish the effect of arachidonic acid, the precursor of PGE2, on experimental hypertension in the rat. The experimental hypert...

journal_title：Chemico-biological interactions

authors： Laborit H,Valette N

更新日期：1975-04-01 00:00:00

abstract：:The extent of DNA modification in cancerous rat live and lung tissues was investigated and compared to their respective normal tissues. Liver tumors were induced by 2-fluorenylacetamide (2-FAA) or N-nitroso-N-2-fluorenylacetamide (N-NO-2-FAA), and lung tumors were induced by sodium nitrite plus trimethylamine. In the ...

journal_title：Chemico-biological interactions

authors： Wang YJ,Ho YS,Lo MJ,Lin JK

更新日期：1995-02-01 00:00:00

abstract：:Vascular disease is a major cause of morbidity and mortality among transplanted recipients and cyclosporine (CsA) treatment has been consistently implicated in this event. In this study we assessed total blood homocysteine levels (tHcy), ecto-nucleotidase activities and adenine nucleotide/nucleoside levels searching f...

journal_title：Chemico-biological interactions

authors： Böhmer AE,Brum LM,Souza DG,Corrêa AM,Oses JP,Viola GG,Saraiva PJ,Driemeier D,Portela LV,Souza DO

更新日期：2010-10-06 00:00:00

abstract：:This study assessed the effect of the combination of anethole and ibuprofen in comparison with monotherapy by either drug alone, using two in vivo inflammatory models, namely the pleurisy and paw edema in rats. We also measured the levels of the TNF protein in plasma, and the ability of anethole to inhibit, in vitro, ...

journal_title：Chemico-biological interactions

authors： Wisniewski-Rebecca ES,Rocha BA,Wiirzler LA,Cuman RK,Velazquez-Martinez CA,Bersani-Amado CA

更新日期：2015-12-05 00:00:00

abstract：:Our laboratory has been routinely using suspended and cultured human hepatocytes for predicting drug metabolism and enzyme induction by drug candidates to aid drug discovery. Increasing limitation and irregular availability of human tissue has indicated the need for maximizing the use of this valuable resource. Cryopr...

journal_title：Chemico-biological interactions

authors： Silva JM,Day SH,Nicoll-Griffith DA

更新日期：1999-06-01 00:00:00

abstract：:Colon epithelium is made up of two general classes of cells, surface cells which are post-mitotic and crypt cells which contain the proliferative population. Their relative vulnerability to environmental damage and ability to perform DNA repair are important issues in colon carcinogenesis. DNA damage and repair was st...

journal_title：Chemico-biological interactions

authors： Kulkarni MS,Yielding KL

更新日期：1985-01-01 00:00:00

abstract：:Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor. In this paper, we report that B12H (24-h pretreatment) effectively blocked glutamate-induced neuronal excitotoxicity in cerebellar granule neurons (CGNs). Howev...

journal_title：Chemico-biological interactions

authors： Cui W,Hu S,Chan HH,Luo J,Li W,Mak S,Choi TC,Rong J,Carlier PR,Han Y

更新日期：2013-03-25 00:00:00

abstract：:Recent evidences highlighted that histone deacetylases (HDACs) can deacetylate the histone, various transcription factors and regulatory proteins, which directly or indirectly affect glucose metabolism. The present study aimed to evaluate the comparative effects of sodium butyrate (NaB) and metformin on the glucose ho...

journal_title：Chemico-biological interactions

authors： Khan S,Jena G

更新日期：2016-07-25 00:00:00

abstract：:The present study investigated the protective efficacy of dl-alpha-lipoic acid (LA) on adriamycin (ADR)-induced oxidative damage in rat testis. Adult male albino rats of Wistar strain were administered ADR (1 mg/kg body weight, i.v.), once a week for 10 weeks. ADR injected rats showed increased oxidative stress with a...

journal_title：Chemico-biological interactions

authors： Prahalathan C,Selvakumar E,Varalakshmi P

更新日期：2006-03-25 00:00:00

abstract：:Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that limits the clinical use of doxorubicin (DOX) as an anti-tumoral drug, but the mechanism of DOX-mediated apoptosis remains unclear. We examined the interplay between oxidative stress and cell death in cardiac-derived H9c2 myocytes ...

journal_title：Chemico-biological interactions

authors： Bernuzzi F,Recalcati S,Alberghini A,Cairo G

更新日期：2009-01-15 00:00:00

abstract：:Known spectroscopic and kinetic data are used to formulate pathways of the physiological and transfer reactions and the substrate inhibition of phenol sulfotransferase. Kinetic mechanisms indicate that release of PAP from enzyme complex is required for the physiological reaction but not for the transfer reaction. The ...

journal_title：Chemico-biological interactions

authors： Yang YS,Tsai SW,Lin ES

更新日期：1998-02-20 00:00:00

abstract：:Avermectin (AVM) is a macrocyclic lactone agent widely used as a nematicide, acaricide and insecticide in veterinary medicine and plant protection. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump for xenobiotic compounds, and is involved in multidrug resistance. To understand the development of AVM resistan...

journal_title：Chemico-biological interactions

authors： Luo L,Sun YJ,Yang L,Huang S,Wu YJ

更新日期：2013-04-25 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the responses to toxic environmental chemicals such as TCDD or dioxin-like PCBs. To regulate gene expression, the AhR requires its binding partner, the aryl hydrocarbon receptor nuclear translocator (ARNT). ARNT is als...

journal_title：Chemico-biological interactions

authors： Vorrink SU,Domann FE

更新日期：2014-07-25 00:00:00

abstract：:Sensitivities of the strains belonging to four vibrio biotypes to the action of furazolidone were investigated. Vibrio cholerae (classical) was most and Vibrio parahaemolyticus least sensitive to this drug. Statistical analyses revealed significant differences between any two of the four types of vibrio in respect of ...

journal_title：Chemico-biological interactions

authors： Banerjee SK,Chatterjee SN

更新日期：1981-11-01 00:00:00