Abstract:
:Using a rat liver cytosol source of enzyme trialkyl phosphorothioates have been shown to be substrates of glutathione S-transferases. Using OSS-trimethyl phosphorodithioate (OSS-Me(O] and OOS-trimethyl phosphorothioate (OOS-Me(O] the methyl transferred to the sulphydryl of glutathione is that attached to phosphorus via an oxygen atom. Fractionation of liver cytosol has shown that although the bulk activity is due to the three isozymes (1-1; 3-4; 1.2), OSS-Me(O) is a general substrate for glutathione S-transferases. The specific activity is low compared with the substrates 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene.
journal_name
Chem Biol Interactjournal_title
Chemico-biological interactionsauthors
Aldridge WN,Grasdalen H,Aarstad K,Street BW,Norkov Tdoi
10.1016/s0009-2797(85)80166-6subject
Has Abstractpub_date
1985-07-01 00:00:00pages
243-56issue
2eissn
0009-2797issn
1872-7786journal_volume
54pub_type
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