Permeability of lipid bilayers to methylmercuric chloride: quantification by fluorescence quenching of a carbazole-labeled phospholipid.

abstract：:Dimethylnitrosamine (DMN) is a potent hepatotoxic, carcinogenic and mutagenic compound. It induces massive liver cell necrosis and death in experimental animals. Several drugs have been tested in the past for their protective behavior against DMN toxicity. However, it is for the first time that therapeutic interventio...

journal_title：Chemico-biological interactions

authors： Rani V,Verma Y,Rana K,Rana SVS

更新日期：2018-11-01 00:00:00

abstract：:Methylmercury is a widely distributed environmental toxicant with detrimental effects on the developing and adult nervous system. Due to its accumulation in the food chain, chronic exposure to methylmercury via consumption of fish and sea mammals is still a major concern for human health, especially developmental expo...

journal_title：Chemico-biological interactions

authors： Ceccatelli S,Daré E,Moors M

更新日期：2010-11-05 00:00:00

abstract：:The reaction of 2'-deoxyguanosine (1), substituted hydrazines (Hy) and oxygen, in the presence of Cu(II) as catalyst, yields 8-hydroxy-2'-deoxyguanosine (2). The rate of formation of 2 was found to be dependent upon the oxidation potential of the Hy and on structural factors of the Hy. The conversion of 1 to 2 under t...

journal_title：Chemico-biological interactions

authors： Gannett PM,Dalal NS,Shi XL,Toth B

更新日期：1991-01-01 00:00:00

abstract：:Melatonin and S-adenosyl-l-methionine (SAMe) prevent oxidative stress and tissue dysfunction in obstructive jaundice (OJ). Lipid peroxidation is exacerbated in the presence of trace amounts of iron (Fe). The study investigated the regulation by melatonin and SAMe the induction of oxidative stress, iron metabolism dist...

journal_title：Chemico-biological interactions

authors： Muñoz-Castañeda JR,Túnez I,Herencia C,Ranchal I,González R,Ramírez LM,Arjona A,Barcos M,Espejo I,Cruz A,Montilla P,Padillo FJ,Muntané J

更新日期：2008-07-30 00:00:00

abstract：:The secretion of digoxin and digitoxin into in situ perfused jejunal and colonic segments of normal or quinidine treated guinea pigs was studied. Quinidine was administered intravenously by constant rate infusion resulting in a quinidine plasma concentration of about 6 micrograms/ml. After 2 h digoxin or digitoxin was...

journal_title：Chemico-biological interactions

authors： Schäfer SG,Schuhmann G,Doering W,Fichtl B

更新日期：1985-10-01 00:00:00

abstract：:ATP mediates covalent binding of hydroxymethyl derivatives of aromatic hydrocarbons to DNA. This non-enzymatic reaction has been studied with 6-[14C]hydroxymethylbenzo[alpha]pyrene (]14C]BP-6-CH2OH) and 7-[14C]-hydroxymethylbenz[alpha]anthracene ([14C]BA-7-CH2OH) at 37 degrees C in Tris buffer (pH 7.0). While ADP medi...

journal_title：Chemico-biological interactions

authors： Rogan EG,Roth RW,Katomski-Beck PA,Laubscher JR,Cavalieri EL

更新日期：1980-07-01 00:00:00

abstract：:Phenazines, naturally produced by bacteria and archaeal Methanosarcina species are nitrogen-containing tricyclic molecules with antibiotic, antitumoral, and antiparasitic activities. Phenazines are used as electron acceptors-donors in wide range of fields including environmental biosensors. In this study, the inhibito...

journal_title：Chemico-biological interactions

authors： Onder S,Biberoglu K,Tacal O

更新日期：2019-12-01 00:00:00

abstract：:Butyrylcholinesterase (BChE) has proven to be an effective bioscavenger against nerve agents and organophosphates. Phase I safety trials of human BChE are currently being conducted and large-scale production of recombinant BChE is underway. Information on the real-time distribution of BChE from the injection site has ...

journal_title：Chemico-biological interactions

authors： Duysen EG,Lockridge O

更新日期：2008-09-25 00:00:00

abstract：:Toxic medium chain length alkanals, alkenals, and 4-hydroxyalkenals that are generated during lipid peroxidation are potential substrates for aldehyde dehydrogenase (ALDH) isoforms. We have developed transgenic cell lines to examine the potential for either human ALDH1A1 or ALDH3A1 to protect against damage mediated b...

journal_title：Chemico-biological interactions

authors： Townsend AJ,Leone-Kabler S,Haynes RL,Wu Y,Szweda L,Bunting KD

更新日期：2001-01-30 00:00:00

abstract：:Incubation of Ca2(+)-loaded rat liver mitochondria with N-acetyl-p-benzoquinone imine (NAPQI) or its two dimethylated analogues resulted in a concentration dependent Ca2+ release, with the following order of potency: 2,6-(Me)2-NAPQI greater than NAPQI greater than 3,5-(Me)2-NAPQI. The quinone imine-induced Ca2+ releas...

journal_title：Chemico-biological interactions

authors： Weis M,Moore GA,Cotgreave IA,Nelson SD,Moldeus P

更新日期：1990-01-01 00:00:00

abstract：:Keloid is an overgrowth of scar tissue that develops around a wound. The mechanisms of keloid formation and development still remain unknown, and no effective treatment is available. Searching for active natural resources may develop better prevention and treatment approaches for keloids. Aspidin PB is a natural resou...

journal_title：Chemico-biological interactions

authors： Song R,Li G,Li S

更新日期：2015-08-05 00:00:00

abstract：:The aim of this study was to evaluate the effects of organosulfurs, isothiocyanates and vitamin C towards hydrogen peroxide-induced DNA damage (DNA strand breaks and oxidized purines/pyrimidines) in human hepatoma cells (HepG2), using the Comet assay. Treatment with hydrogen peroxide (H(2)O(2)) increased the levels of...

journal_title：Chemico-biological interactions

authors： Arranz N,Haza AI,García A,Delgado E,Rafter J,Morales P

更新日期：2007-08-15 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors are a promising new class of anticancer agents that act by inhibiting cell proliferation and inducing apoptosis in a variety of cancer cells. Although apicidin acts as a potent HDAC inhibitor, the precise mechanism for its anti-tumor activity in human endometrial cancer cells is n...

journal_title：Chemico-biological interactions

authors： Ahn MY,Lee J,Na YJ,Choi WS,Lee BM,Kang KW,Kim HS

更新日期：2009-05-15 00:00:00

abstract：:Cloning of the androgen and estrogen sulfotransferases has allowed studies on their spatiotemporal regulation and physiological function. These two enzymes appear to be involved in regulating target cell sensitivity for the androgenic and estrogenic steroids. Recombinant androgen sulfotransferase produced in insect Sf...

journal_title：Chemico-biological interactions

authors： Chatterjee B,Song CS,Kim JM,Roy AK

更新日期：1994-06-01 00:00:00

abstract：:This article presents an overview of occupational benzene exposures in China based on data published in Chinese medical journals. The data were derived from 384 reports of benzene poisoning or industrial hygiene surveys published in Chinese medical journals between 1960 and 2003. The following information was extracte...

journal_title：Chemico-biological interactions

authors： Liang YX,Wong O,Armstrong T,Ye XB,Miao LZ,Zhou YM,Wu QE,Qian HJ,Fu H

更新日期：2005-05-30 00:00:00

abstract：:The dynamic development of metal-containing anticancer drugs has started since the discovery of cis-diamminedichloroplatinum(II). For many years it was believed that trans platinum(II) compounds were non-active as antitumour agents because trans-diamminedichloroplatinum is biologically inactive although it binds to DN...

journal_title：Chemico-biological interactions

authors： Matlawska-Wasowska K,Rainczuk K,Kalinowska-Lis U,Osiecka R,Ochocki J

更新日期：2007-06-30 00:00:00

abstract：:2,4,6-Triphenyldioxane-1,3 (TPD) is a highly effective species-specific inducer of CYP2В in rats. Several analogs of TPD were synthesized to verify a hypothesis that minor changes in the inducer structure can cause changes in induction abilities (R=H, cisTPD and transTPD; R=N(CH(3))(2), transpDMA; R=NO(2), transpNO(2)...

journal_title：Chemico-biological interactions

authors： Pustylnyak V,Yarushkin A,Kachaylo E,Slynko N,Lyakhovich V,Gulyaeva L

更新日期：2011-07-15 00:00:00

abstract：:Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhib...

journal_title：Chemico-biological interactions

authors： Chen A,Qin X,Tang Y,Liu M,Wang X

更新日期：2014-10-05 00:00:00

abstract：:The lipopolysaccharide (LPS)-Toll-like receptor 4 (TLR4) signaling pathway in alveolar epithelial cells plays an important role in many pathologic processes such as acute lung injury (ALI). The single immunoglobulin IL-1 receptor-related protein (SIGIRR) is an inhibitor of LPS-TLR4 signaling, but its expression and fu...

journal_title：Chemico-biological interactions

authors： Feng T,Yunfeng N,Jinbo Z,Zhipei Z,Huizhong Z,Li L,Tao J,Yunjie W

更新日期：2010-02-12 00:00:00

abstract：:Since skin cancer incidence and prevalence is constantly rising up the charts despite all efforts, search for newer, better agents for protection and treatment is required. Ginger (Zingiber officinale Roscoe), a monocotyledonous herb, is widely used as a herbal medicine, given the presence of homologous phenolic keton...

journal_title：Chemico-biological interactions

authors： Nigam N,Bhui K,Prasad S,George J,Shukla Y

更新日期：2009-09-14 00:00:00

abstract：:Inhibition of microtubule assembly by arenastatin A (1) and five synthetic analogs (3-7) was examined. Arenastatin A and the triamide 6 showed potent and moderately strong inhibitory activities, respectively (IC50; 2.3 microM for 1, 7.8 microM for 6) and also depolymerized preformed microtubules. The other analogs tes...

journal_title：Chemico-biological interactions

authors： Koiso Y,Morita K,Kobayashi M,Wang W,Ohyabu N,Iwasaki S

更新日期：1996-12-20 00:00:00

abstract：:As part of our continuing search for bioactive natural products from plants, the present study was carried out in order to evaluate the gastroprotective properties of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora (Rutaceae). Anti-ulcer assays were performed using the following pro...

journal_title：Chemico-biological interactions

authors： Zanatta F,Gandolfi RB,Lemos M,Ticona JC,Gimenez A,Clasen BK,Cechinel Filho V,de Andrade SF

更新日期：2009-07-15 00:00:00

abstract：:Aldehyde dehydrogenase 2 (ALDH2) catalyzes oxidation of toxic aldehydes to carboxylic acids. Physiologic levels of Mg(2+) ions influence ALDH2 activity in part by increasing NADH binding affinity. Traditional fluorescence measurements monitor the blue shift of the NADH fluorescence spectrum to study ALDH2-NADH interac...

journal_title：Chemico-biological interactions

authors： Gonnella TP,Leedahl TS,Karlstad JP,Picklo MJ

更新日期：2011-05-30 00:00:00

abstract：:We report here for the first time that germanium oxide (GeO(2)) blocks cell progression. GeO(2) is not genotoxic to Chinese hamster ovary (CHO) cells and has limited cytotoxicity. However, GeO(2) arrests cells at G2/M phase. The proportion of cells stopped at G2/M phase increased dose-dependently up to 5 mM GeO(2) whe...

journal_title：Chemico-biological interactions

authors： Chiu SJ,Lee MY,Chen HW,Chou WG,Lin LY

更新日期：2002-10-20 00:00:00

abstract：:Dopa was oxidized by Mn(3+)-pyrophosphate complex to the corresponding o-quinone, accompanied by the cyclization of the amino chain to form cyclized dopa ortho-quinone (cDoQ) with absorption maxima at wavelengths of 305 and 475 nm. The cyclization was found to proceed in a single step from DoQ to cDoQ without formatio...

journal_title：Chemico-biological interactions

authors： Baez S,Linderson Y,Segura-Aguilar J

更新日期：1994-11-01 00:00:00

abstract：:Structure-uncoupling activity relationship of seven anthraquinone derivatives were investigated using rat liver mitochondria. Three compounds bearing the free hydroxyl group at the beta-position of their anthraquinone nucleus (1,3,6,8-tetrahydroxyanthraquinone, 1-acetyl-2,4,5,7-tetrahydroxy-9,10-anthracenedione and sk...

journal_title：Chemico-biological interactions

authors： Betina V,Kuzela S

更新日期：1987-01-01 00:00:00

abstract：:Chronic exposure of humans to benzene causes severe bone marrow cell depression leading to aplastic anemia. Marrow stromal macrophage dysfunction and deficient interleukin-1 production has been reported for patients with severe aplastic anemia. The stromal macrophage, a target of benzene toxicity, is involved in hemat...

journal_title：Chemico-biological interactions

authors： Niculescu R,Bradford HN,Colman RW,Kalf GF

更新日期：1995-12-22 00:00:00

abstract：:Acetaldehyde (AA) and methylglyoxal (MG) are reactive, ubiquitous aldehydes, present in the environment and endogenously formed in animals and humans. They have both been shown to readily form DNA adducts under simulated physiological conditions. We report here on the use of cultured normal and SV40T antigen-immortali...

journal_title：Chemico-biological interactions

authors： Vaca CE,Nilsson JA,Fang JL,Grafström RC

更新日期：1998-01-30 00:00:00

abstract：:HPV infections in the oral cavity that progress to cancer are on the increase in the USA. Model systems to study co-factors for progression of these infections are lacking as HPVs are species-restricted and cannot grow in preclinical animal models. We have recently developed a mouse papillomavirus (MmuPV1) oral mucosa...

journal_title：Chemico-biological interactions

authors： Christensen ND,Chen KM,Hu J,Stairs DB,Sun YW,Aliaga C,Balogh KK,Atkins H,Shearer D,Li J,Brendle SA,Gowda K,Amin S,Walter V,Viscidi R,El-Bayoumy K

更新日期：2021-01-05 00:00:00

abstract：:Sensitivities of the strains belonging to four vibrio biotypes to the action of furazolidone were investigated. Vibrio cholerae (classical) was most and Vibrio parahaemolyticus least sensitive to this drug. Statistical analyses revealed significant differences between any two of the four types of vibrio in respect of ...

journal_title：Chemico-biological interactions

authors： Banerjee SK,Chatterjee SN

更新日期：1981-11-01 00:00:00