Androgen and estrogen sulfotransferases of the rat liver: physiological function, molecular cloning, and in vitro expression.

Abstract:

:Cloning of the androgen and estrogen sulfotransferases has allowed studies on their spatiotemporal regulation and physiological function. These two enzymes appear to be involved in regulating target cell sensitivity for the androgenic and estrogenic steroids. Recombinant androgen sulfotransferase produced in insect Sf9 cells through a baculoviral expression vector is capable of transferring the sulfate from PAPS (phosphoadenosine phosphosulfate) to 3 alpha, 3 beta, 17 alpha, and 17 beta hydroxyl groups of a number of steroid substrates indicating a broad range of substrate specificity.

journal_name

Chem Biol Interact

authors

Chatterjee B,Song CS,Kim JM,Roy AK

doi

10.1016/0009-2797(94)90069-8

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

273-9

issue

1-3

eissn

0009-2797

issn

1872-7786

pii

0009-2797(94)90069-8

journal_volume

92

pub_type

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