当前位置： SCI文献检索 > CHEMICO-BIOLOGICAL INTERACTIONS期刊下所有文献 > Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats.

Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats.

Abstract：

:Melatonin and S-adenosyl-l-methionine (SAMe) prevent oxidative stress and tissue dysfunction in obstructive jaundice (OJ). Lipid peroxidation is exacerbated in the presence of trace amounts of iron (Fe). The study investigated the regulation by melatonin and SAMe the induction of oxidative stress, iron metabolism disturbances and tissue injury in an experimental model of OJ. Different parameters of lipid peroxidation, antioxidant status, tissue injury and Fe metabolism were determined in liver and blood. OJ induced Fe accumulation in liver, and increased transferrin (Tf) saturation and loosely bound Fe content in blood. Melatonin, and SAMe at lesser extent, enhanced protein Tf content in liver and blood, that reduced loosely bound Fe content in blood. Melatonin and SAMe did not affect ferritin (FT) and Tf mRNA expression, but reduced Tf receptor (TfR) mRNA expression in liver. In conclusion, the effect of melatonin and SAMe on Fe metabolism may be included in the beneficial properties of these agents on lipid peroxidation and tissue injury induced by OJ.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Muñoz-Castañeda JR,Túnez I,Herencia C,Ranchal I,González R,Ramírez LM,Arjona A,Barcos M,Espejo I,Cruz A,Montilla P,Padillo FJ,Muntané J

doi

10.1016/j.cbi.2008.05.016

subject

Has Abstract

pub_date

2008-07-30 00:00:00

pages

79-87

issue

2

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(08)00274-3

journal_volume

174

pub_type

杂志文章

相关文献

CHEMICO-BIOLOGICAL INTERACTIONS文献大全
  • In vivo repair of rat liver DNA damaged by dimethylnitrosamine or diethylnitrosamine.

    abstract：:Effects of hepatocarcinogens dimethylnitrosamine (DMN) and diethylnitrosamine (DEN) on the sedimentation pattern of rat liver DNA in alkaline sucrose gradients were studied with regard to time and dose dependency. Both DMN (10 mg/kg body weight) and den (13.4 or 134 mg/kg) induced appreciably decreased DNA sedimentati...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(77)90046-1

    authors： Den Engelse L,Philippus EJ

    更新日期：1977-10-01 00:00:00

  • In vitro meningeal permeation of MnFe2O4 nanoparticles.

    abstract：:MnFe2O4 nanoparticles (NPs) are commonly produced in some occupational settings and may reach high concentration in activities such as arc-welding or ferroalloy metallurgy. Manganese is an essential cofactor in enzyme activities but it has been demonstrated that long-term exposure to excessive levels can lead to "mang...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2018.07.020

    authors： Mauro M,Crosera M,Bovenzi M,Adami G,Baracchini E,Maina G,Filon FL

    更新日期：2018-09-25 00:00:00

  • The binding of benz(a)anthracene derivatives to glyceraldehyde-3-phosphate dehydrogenase and mammary tissue following exposure to laboratory light.

    abstract：:7,12-Dimethylbenz(a)anthracene (DMBA) and 7-methoxymethyl-12-methylbenz(a)anthracene (MeO-DMBA) are converted to a number of products during short exposures in aqueous suspension to laboratory illumination. The mixture of products binds to glyceraldehyde-3-phosphate dehydrogenase (GPDH) while inhibiting its activity b...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(76)90095-8

    authors： Grubbs CJ,Wood JL

    更新日期：1976-02-01 00:00:00

  • Potential implication of aniline derivatives in the Toxic Oil Syndrome (TOS).

    abstract：:The Toxic Oil Syndrome (TOS) was an epidemic disease appeared in central Spain in 1981, causing over 400 deaths and affecting more than 20,000 people, mainly women and children. The disease was linked to the consumption of rapeseed oil denatured with aniline, illegally refined at the ITH oil refinery in Seville, mixed...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2010.10.006

    authors： Messeguer A

    更新日期：2011-06-30 00:00:00

  • Purification of transgenic plant-derived recombinant human acetylcholinesterase-R.

    abstract：:Nicotiana benthamiana plants were engineered to express a codon-optimized gene encoding the human acetylcholinesterase-R (AChE) isoform. The transgenic plants expressed the protein at >0.4% of total soluble protein, and the plant-produced enzyme was purified to homogeneity. Following lysis, procainamide affinity chrom...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2005.10.097

    authors： Geyer BC,Muralidharan M,Cherni I,Doran J,Fletcher SP,Evron T,Soreq H,Mor TS

    更新日期：2005-12-15 00:00:00

  • Calcium phosphate nanoparticles are associated with inorganic phosphate-induced osteogenic differentiation of rat bone marrow stromal cells.

    abstract：:In the present study, we demonstrated that calcium phosphate (CaP) nanoparticles formed in cell culture media were implicated in the process of high inorganic phosphate (Pi) mediated osteogenic differentiation of rat bone marrow stromal cells (BMSCs). Exposure of BMSCs in vitro to high Pi-containing media reduced alka...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2015.06.027

    authors： Chen XR,Bai J,Yuan SJ,Yu CX,Huang J,Zhang TL,Wang K

    更新日期：2015-08-05 00:00:00

  • Microsomal metabolism of hexavalent chromium. Inhibitory effect of oxygen and involvement of cytochrome P-450.

    abstract：:The reduction of hexavalent chromium (Cr(VI] by rat liver microsomes was studied. With 15-120 microM Na2CrO4 microsomes (0.5 mg protein/ml) effectively reduced Cr(VI) in the presence of NADPH provided anaerobic conditions. Phenobarbital (PB) and Aroclor 1254 (PCB) pretreatment increased microsomal Cr(VI) reduction whi...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(89)90076-8

    authors： Mikalsen A,Alexander J,Ryberg D

    更新日期：1989-01-01 00:00:00

  • A spectrophotometric assay of gamma-glutamylcysteine synthetase and glutathione synthetase in crude extracts from tissues and cultured mammalian cells.

    abstract：:An assay of gamma-glutamylcysteine synthetase (gamma-GCS) and glutathione synthetase (GS) in crude extracts of cultured cells and tissues is described. It represents a novel combination of known methods, and is based on the formation of glutathione (GSH) from cysteine, glutamate and glycine in the presence of rat kidn...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(02)00017-0

    authors： Volohonsky G,Tuby CN,Porat N,Wellman-Rousseau M,Visvikis A,Leroy P,Rashi S,Steinberg P,Stark AA

    更新日期：2002-04-20 00:00:00

  • Anticancer activity and radiosensitization effect of methyleneisoxazolidin-5-ones in hepatocellular carcinoma HepG2 cells.

    abstract：:Parthenolide (PTL), a well-known sesquiterpene lactone of natural origin with α,β-unsaturated carbonyl structure, has proven to show promising anti-cancer properties. In this report, anti-proliferative potential of two synthetic methyleneisoxazolidin-5-ones, MZ-6 and MZ-14, with the same structural motif, has been inv...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2016.01.011

    authors： Gach K,Grądzka I,Wasyk I,Męczyńska-Wielgosz S,Iwaneńko T,Szymański J,Koszuk J,Janecki T,Kruszewski M,Janecka A

    更新日期：2016-03-25 00:00:00

  • Structure-function relationships of the alpha/beta-hydrolase fold domain of neuroligin: a comparison with acetylcholinesterase.

    abstract：:The neuroligins are postsynaptic cell adhesion proteins whose extracellular domain belongs to the alpha/beta-hydrolase fold family of proteins, a family characterized through the enzyme acetylcholinesterase (AChE) and other enzymes with various substrate specificities. Neuroligin associations with the pre-synaptic neu...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2010.01.030

    authors： Leone P,Comoletti D,Taylor P,Bourne Y,Marchot P

    更新日期：2010-09-06 00:00:00

  • Cadmium induces the activation of cell wall integrity pathway in budding yeast.

    abstract：:MAP kinases are important signaling molecules regulating cell survival, proliferation and differentiation, and can be activated by cadmium stress. In this study, we demonstrate that cadmium induces phosphorylation of the yeast cell wall integrity (CWI) pathway_MAP kinase Slt2, and this cadmium-induced CWI activation i...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2015.09.007

    authors： Xiong B,Zhang L,Xu H,Yang Y,Jiang L

    更新日期：2015-10-05 00:00:00

  • Identification of plasma proteins containing sulfite-reactive disulfide bonds.

    abstract：:Plasma protein S-sulfonate compounds (RS-SO-3) have previously been shown to form, presumably by sulfitolysis of disulfide bonds, as a result of exposure to sulfite. In the investigations reported here, we identify two proteins in rabbit plasma, namely albumin and plasma fibronectin, which contain reactive sites for S...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(84)90052-8

    authors： Gregory RE,Gunnison AF

    更新日期：1984-04-01 00:00:00

  • Characterization of expressed human phenol-sulfating phenol sulfotransferase: effect of mutating cys70 on activity and thermostability.

    abstract：:The cDNA for human liver phenol-sulfating phenol sulfotransferase (P-PST) has been cloned and the active enzyme expressed in Cos cells and bacteria. Analysis of the sequence identified two cysteine residues, one of which is highly conserved in the phenol sulfotransferase gene family. Previous studies with the pure hum...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(94)90053-1

    authors： Falany CN,Zhuang W,Falany JL

    更新日期：1994-06-01 00:00:00

  • Acute dieldrin toxicity: effect on the uptake of glucose and leucine and on brush border enzymes in monkey intestine.

    abstract：:Administration of a single oral dose of dieldrin (20 mg/kg body wt.) to rhesus monkeys considerably elevated the uptake of glucose and the activities of brush border sucrase, lactase, maltase and alkaline phosphatase in intestine compared to control animals. Leucine uptake and leucine amino peptidase activity was sign...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(81)90173-3

    authors： Mahmood A,Agarwal N,Sanyal S,Dudeja PK,Subrahmanyam D

    更新日期：1981-10-01 00:00:00

  • The metabolism and antitumour activity of the enantiomers of cis- and trans-4-methylcyclophosphamide.

    abstract：:4-Methylcyclophosphamide, an analogue of the antitumour agent cyclophosphamide, exists in cis and trans forms, each of which comprises a pair of optical isomers. The extents of metabolism by rat liver microsomes during 20 min were compared for the four steroisomers incubated separately, and for the racemic cis and tra...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(77)90140-5

    authors： Farmer PB,Jarman M,Facchinetti T,Pankiewicz K,Stec WJ

    更新日期：1977-07-01 00:00:00

  • Butyrylcholinesterase radioligands to image Alzheimer's disease brain.

    abstract：:Butyrylcholinesterase (BuChE) is found to have a brain distribution pattern that is distinct from that of acetylcholinesterase (AChE). Neurons containing BuChE are particularly located in the amygdala, hippocampal formation and the thalamus, structures involved in the normal functions of cognition and behavior that ty...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2012.08.009

    authors： Darvesh S

    更新日期：2013-03-25 00:00:00

  • Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition.

    abstract：:The hypolipidemic fibrates have been identified as agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha), which plays a critical role in the regulation of cardiac fatty acid metabolism. Despite the widespread clinical use of fibrates, their role in myocardial oxidative stress and fatty acid comp...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2006.02.003

    authors： Tian Q,Grzemski FA,Panagiotopoulos S,Ahokas JT

    更新日期：2006-04-15 00:00:00

  • Different metabolic pathways of 2,5-difluoronitrobenzene and 2,5-difluoroaminobenzene compared to molecular orbital substrate characteristics.

    abstract：:The in vivo metabolite patterns of 2,5-difluoroaminobenzene and of its nitrobenzene analogue, 2,5-difluoronitrobenzene, were determined using 19F NMR analysis of urine samples. Results obtained demonstrate significant differences between the biotransformation patterns of these two analogues. For the aminobenzene, cyto...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(94)03317-2

    authors： Rietjens IM,Cnubben NH,van Haandel M,Tyrakowska B,Soffers AE,Vervoort J

    更新日期：1995-01-01 00:00:00

  • An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties.

    abstract：:Butyrylcholinesterase (BChE, EC 3.1.1.8) is important in human cocaine metabolism despite its limited ability to hydrolyze this drug. Efforts to improve the catalytic efficiency of this enzyme have led to a quadruple mutant cocaine hydrolase, "CocH", that in animal models of addiction appears promising for treatment o...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2008.04.024

    authors： Gao Y,LaFleur D,Shah R,Zhao Q,Singh M,Brimijoin S

    更新日期：2008-09-25 00:00:00

  • Protective effect of rat aldo-keto reductase (AKR1C15) on endothelial cell damage elicited by 4-hydroxy-2-nonenal.

    abstract：:4-Hydroxy-2-nonenal (HNE), a major reactive product of lipid peroxidation, is believed to play a central role in atherogenic actions triggered by oxidized lipoproteins. An aldo-keto reductase (AKR) 1C15 efficiently reduces HNE and is distributed in many rat tissues including endothelial cells. In this study, we invest...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2010.12.018

    authors： Matsunaga T,Shinoda Y,Inoue Y,Endo S,El-Kabbani O,Hara A

    更新日期：2011-05-30 00:00:00

  • S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis.

    abstract：:Endocrine therapies (e.g. tamoxifen and aromatase inhibitors) targeting estrogen action are effective in decreasing mortality of breast cancer. However, their efficacy is limited by intrinsic and acquired resistance. Our previous study demonstrated that overexpression of a histone methyltransferase NSD2 drives tamoxif...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.108965

    authors： Wang Q,Zheng J,Zou JX,Xu J,Han F,Xiang S,Liu P,Chen HW,Wang J

    更新日期：2020-02-01 00:00:00

  • Superoxide dismutase and catalase prevent the formation of reactive oxygen species during reduction of cyclized dopa ortho-quinone by DT-diaphorase.

    abstract：:Dopa was oxidized by Mn(3+)-pyrophosphate complex to the corresponding o-quinone, accompanied by the cyclization of the amino chain to form cyclized dopa ortho-quinone (cDoQ) with absorption maxima at wavelengths of 305 and 475 nm. The cyclization was found to proceed in a single step from DoQ to cDoQ without formatio...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(94)90090-6

    authors： Baez S,Linderson Y,Segura-Aguilar J

    更新日期：1994-11-01 00:00:00

  • Human erythrocytes and molecular models of cell membranes are affected in vitro by Balbisia peduncularis (Amancay) extracts.

    abstract：:Balbisia peduncularis, also known as "Amancay", is a plant of the Ledocarpaceae family that can be found in the Atacama Desert in northern Chile. Infusions of the plant have long being used in traditional herbal medicine. Its chemical composition indicates the presence of flavonoids, which have antioxidant properties....

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2008.12.011

    authors： Suwalsky M,Oyarce K,Avello M,Villena F,Sotomayor CP

    更新日期：2009-05-15 00:00:00

  • Differential inhibition of hepatic microsomal alkoxyresorufin O-dealkylation activities by tetrachlorobiphenyls.

    abstract：:Polychlorinated biphenyls (PCBs) elicit a spectrum of biochemical and toxic effects in exposed animals. In the present study, we assessed the effect of PCB structure, using four symmetrically-substituted PCBs, on cytochrome P450 (CYP)-mediated methoxy-, ethoxy- and benzyloxyresorufin O-dealkylase (MROD, EROD and BROD,...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2007.05.004

    authors： Edwards PR,Hrycay EG,Bandiera SM

    更新日期：2007-08-15 00:00:00

  • Screening of O-ethyl O-4-nitrophenyl phosphoramidate (ENPP) for delayed neuropathic potential.

    abstract：:O-Ethyl-O-4-nitrophenylphosphoramidate is a short-acting anticholinesterase and a possible candidate for a prophylactic agent against nerve agents since human acetylcholinesterase inhibited by this agent undergoes rapid spontaneous reactivation which can be accelerated further, if necessary, by treatment with oximes. ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(93)90072-7

    authors： Johnson MK,Read DJ

    更新日期：1993-06-01 00:00:00

  • Traces of copper ions deplete glutathione in human hepatoma cell cultures with low cysteine content.

    abstract：BACKGROUND:Cell death induced by intracellular glutathione depletion has been reported to be dependent on the presence of trace amounts of extracellular copper ions. Since little is known about the relationship between glutathione depletion and copper homeostasis, we have in the present study further investigated the r...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2007.01.005

    authors： Hultberg M,Isaksson A,Andersson A,Hultberg B

    更新日期：2007-04-05 00:00:00

  • New insights into the role of melatonin in plants and animals.

    abstract：:Melatonin is a hormone produced in animals by the pineal gland and in plants under stress. Melatonin research has expanded rapidly, affecting an impressive enhancement in the understanding of its functions in plants and animals. However, far less focus has been directed to clarifying the nature of melatonin dose-respo...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbi.2018.12.008

    authors： Agathokleous E,Kitao M,Calabrese EJ

    更新日期：2019-02-01 00:00:00

  • Saxagliptin protects against hypoxia-induced damage in H9c2 cells.

    abstract：:Type II diabetes is recognized as a major risk factor for death due to cardiovascular complications such as coronary heart disease (CHD), but the complex interplay between these two diseases remains poorly understood. Suppression of oxidative stress, apoptosis, and inflammation of endothelial cells is a valuable treat...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2019.108864

    authors： Zhang L,Qi X,Zhang G,Zhang Y,Tian J

    更新日期：2020-01-05 00:00:00

  • Lysis of egg phosphatidylcholine vesicles by tricyclic carboxamide antitumor agents.

    abstract：:The stability of small unilamellar vesicles formed by egg phosphatidylcholine has been examined in the presence of 38 tricyclic carboxamide DNA-intercalating agents (19 phenylquinolines, 17 phenylbenzimidazoles, an acridine and an anthracene). Lysis of the vesicular membrane is time-dependent and also dependent on the...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(90)90025-i

    authors： O'Connor CJ,Emery DP,Tank H,Denny WA,Sunamoto J

    更新日期：1990-01-01 00:00:00

  • Effects of ochratoxin A metabolites on yeast phenylalanyl-tRNA synthetase and on the growth and in vivo protein synthesis of hepatoma cells.

    abstract：:The ochratoxin A (OTA) metabolite (4R)-4-hydroxyochratoxin A [4R)-OTA) inhibits the aminoacylation of phenylalanine tRNA catalyzed by phenylalanyl-tRNA synthetase (PheRS) with a Ki-value of 0.9 mM as compared to 1.3 mM for OTA. It also inhibits protein synthesis and cell growth in the same manner as OTA. Ochratoxin al...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(83)90160-6

    authors： Creppy EE,Størmer FC,Kern D,Röschenthaler R,Dirheimer G

    更新日期：1983-11-01 00:00:00