Effects of arenastatin A and its synthetic analogs on microtubule assembly.

abstract：:Due to the dominating roles that caspases play in the apoptotic cascade, their activities appear to be a primary factor in the death pathway (apoptosis versus oncosis/necrosis) decision. In murine FL5.12 proB lymphocytes, the cellular consequences of acrolein treatment included a lack of typical apoptotic features in ...

journal_title：Chemico-biological interactions

authors： Kern JC,Kehrer JP

更新日期：2002-01-22 00:00:00

abstract：:The lethal effects of linoleic acid and its hydroperoxide on human diploid fibroblasts were quite similar, and that of the reaction mixture from the autoxidation of the hydroperoxide was considerable. Some unsaturated aliphatic aldehydes, the secondary products of the hydroperoxide autoxidation, were identified and th...

journal_title：Chemico-biological interactions

authors： Kaneko T,Honda S,Nakano S,Matsuo M

更新日期：1987-01-01 00:00:00

abstract：:Oxidative stress is a cellular or physiological condition of elevated concentrations of reactive oxygen species that cause molecular damage to vital structures and functions. Several factors influence the susceptibility to oxidative stress by affecting the antioxidant status or free oxygen radical generation. Here, we...

journal_title：Chemico-biological interactions

authors： Møller P,Wallin H,Knudsen LE

更新日期：1996-09-27 00:00:00

abstract：:The goal of this research was to test the hypothesis that bioactivation reactions could be exploited to deliver and activate mitochondria-targeted antioxidant prodrugs. The concept that bioactivation reactions could be used for prodrug delivery and activation has received little attention. Most bioactivation reactions...

journal_title：Chemico-biological interactions

authors： Anders MW

更新日期：2011-06-30 00:00:00

abstract：:Metabolism of the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats was compared to metabolism in primary lung and liver cells. Untreated rats and rats pretreated with phenobarbital, acetone or phenethyl isothiocyanate (PEITC) were used for all experiments. Also the influence of...

journal_title：Chemico-biological interactions

authors： Schneider T,Frei E,Wiessler M

更新日期：1999-04-15 00:00:00

abstract：:Avermectin (AVM) is a macrocyclic lactone agent widely used as a nematicide, acaricide and insecticide in veterinary medicine and plant protection. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump for xenobiotic compounds, and is involved in multidrug resistance. To understand the development of AVM resistan...

journal_title：Chemico-biological interactions

authors： Luo L,Sun YJ,Yang L,Huang S,Wu YJ

更新日期：2013-04-25 00:00:00

abstract：:The polycyclic aromatic hydrocarbon (PAH) benzo[ghi]perylene (BghiP) lacks a "classic" bay-region and is therefore unable to form vicinal dihydrodiol epoxides thought to be responsible for the genotoxicity of carcinogenic PAHs like benzo[a]pyrene. The bacterial mutagenicity of BghiP increases considerably after inhibi...

journal_title：Chemico-biological interactions

authors： Platt KL,Grupe S,Fickler M

更新日期：2008-11-25 00:00:00

abstract：:Risperidone has been used in some stress disorders and may be potentially protective against stress-induced gastric lesions. Thus, the aim of the present study is to investigate, whether risperidone, a D(2) receptor and 5-HT(2A) receptor antagonist, would be able to result in gastroprotective effect in stress-induced ...

journal_title：Chemico-biological interactions

authors： Saxena B,Krishnamurthy S,Singh S

更新日期：2011-04-25 00:00:00

abstract：:Sophoricoside (SOPH) is an isoflavone glycoside isolated from the fruits of Sophora japonica. Since its first isolation in 1961, there are rare findings about the effects of SOPH on reproductive system. In the present study, the pregnant mice administrated by different doses of SOPH were used to explore the effect of ...

journal_title：Chemico-biological interactions

authors： Zhou J,Qu C,Sun Q,Wu L,Liu Y,Yang Z,Zhang J

更新日期：2014-08-05 00:00:00

abstract：:This study was undertaken to evaluate the effects of age on a child's susceptibility to developing leukemia following exposure to known leukemogenic agents. The clinical literature describing the risk of developing acute myelogenous leukemia (AML) following treatment with alkylating agents or topoisomerase reactive dr...

journal_title：Chemico-biological interactions

authors： Pyatt DW,Hays SM,Cushing CA

更新日期：2005-05-30 00:00:00

abstract：:An important application of primary hepatocyte cultures is for hepatotoxicity research. In this paper, gel entrapment culture of rat hepatocytes in miniaturized BAL system were evaluated as a potential in vitro model for hepatotoxicity studies in comparison to monolayer cultures. After exposure for 24 and 48 h to acet...

journal_title：Chemico-biological interactions

authors： Shen C,Zhang G,Qiu H,Meng Q

更新日期：2006-07-25 00:00:00

abstract：:Two new flavonoids, bismilachinone (11) and smilachinin (14), were isolated from the leaves of Smilax china L. together with 14 known compounds. Their structures were elucidated using spectroscopic methods. The PTP1B, α-glucosidase, and DPP-IV inhibitory activities of compounds 1-16 were evaluated at the molecular lev...

journal_title：Chemico-biological interactions

authors： Zhao BT,Le DD,Nguyen PH,Ali MY,Choi JS,Min BS,Shin HM,Rhee HI,Woo MH

更新日期：2016-06-25 00:00:00

abstract：:Fosfomycin is clinically recognized to reduce the aminoglycoside antibiotics-induced nephrotoxicity. However, little has been clarified why fosfomycin protects the kidney from the aminoglycosides-induced nephrotoxicity. Gentamicin, a typical aminoglycoside, is reported to cause lipid peroxidation. We focused on lipid ...

journal_title：Chemico-biological interactions

authors： Yanagida C,Ito K,Komiya I,Horie T

更新日期：2004-07-20 00:00:00

abstract：:The peroxyl radicals CF3O2., CCl3O2. and CBr3O2. were produced by radiolysis of aerated aqueous-alcohol solutions of CF3Br, CF3Cl, CCl4 or CBr4. Kinetic spectrophotometric pulse radiolysis experiments were carried out in the presence of various substrates: urate, ascorbate, xanthine, hydroquinone, p-methoxyphenol, phe...

journal_title：Chemico-biological interactions

authors： Huie RE,Brault D,Neta P

更新日期：1987-01-01 00:00:00

abstract：:Pretreatment of secondary cultures of Syrian hamster embryo cells with 7,8-benzoflavone (7,8-BF) inhibited both the metabolism of 7,12-dimethylbenz[alpha] anthracene (DMBA) and the formation of DMBA-DNA adducts. The DMBA-deoxyribonucleoside adducts from 7,8-BF-treated cultures had the same elution profiles on Sephadex...

journal_title：Chemico-biological interactions

authors： Baird WM,Diamond L

更新日期：1978-02-01 00:00:00

abstract：:DL-2-Oxo-3-(2-mercaptoethyl)-5-phenylimidazolidine (OMPI) a sulfhydryl metabolite of levamisole, unlike the parent compound, is shown to interfere with the morphological and functional integrity of microtubules in cultured cells at high concentrations (1.6-10(-4) M). Lower concentrations do not affect the cell morphol...

journal_title：Chemico-biological interactions

authors： De Brabander M,Aerts F,Geuens G,van Ginckel R,van de Veire R,van Belle H

更新日期：1978-10-01 00:00:00

abstract：:The organ specificity of tris(2,3-dibromopropyl)phosphate(Tris-BP)-induced DNA damage was investigated in the rat 2 h after a single i.p. injection of 350 mumol/kg. Extensive DNA damage, measured with the alkaline elution method, was found in the kidney, liver and small intestine. Less, but significant DNA damage was ...

journal_title：Chemico-biological interactions

authors： Søderlund EJ,Brunborg G,Dybing E,Trygg B,Nelson SD,Holme JA

更新日期：1992-04-15 00:00:00

abstract：:N-Hydroxyethylnitroso-N'-ethylurea (HEENU) and N-hydroxyethylnitroso-N'-chloroethylurea (HCNU) are two of the few nitrosoureas which induce hepatocellular tumours in rats without further treatment. In the present study we have investigated whether this is due to selectively elevated levels of DNA hydroxyethylation in ...

journal_title：Chemico-biological interactions

authors： Ludeke B,Schubert M,Yamada Y,Lijinsky W,Kleihues P

更新日期：1991-01-01 00:00:00

abstract：:The antioxidant mechanism of ebselen in rats brain is largely linked with its glutathione peroxidase (GPx) rather than its peroxiredoxin mimicry ability. However, the precise molecular dynamics between the GPx-mimicry of ebselen and thiol utilization is yet to be fully clarified and thus still open. Herein, we investi...

journal_title：Chemico-biological interactions

authors： Kade IJ,Balogun BD,Rocha JB

更新日期：2013-10-25 00:00:00

abstract：:Chronic exposure of humans to benzene causes severe bone marrow cell depression leading to aplastic anemia. Marrow stromal macrophage dysfunction and deficient interleukin-1 production has been reported for patients with severe aplastic anemia. The stromal macrophage, a target of benzene toxicity, is involved in hemat...

journal_title：Chemico-biological interactions

authors： Niculescu R,Bradford HN,Colman RW,Kalf GF

更新日期：1995-12-22 00:00:00

abstract：:To compare the effects of the food toxin 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) and estradiol in hormone-responsive MCF-7 cells, the cells were exposed to different concentrations of either PhIP or estradiol. The effect of various culture conditions (e.g. phenol red, FBS, vehicle (DMSO/EtOH) and seedi...

journal_title：Chemico-biological interactions

authors： Immonen E,Serpi R,Vähäkangas K,Myllynen P

更新日期：2009-11-10 00:00:00

abstract：:Pogostemonis Herba is an important Chinese medicine widely used in the treatment of gastrointestinal dysfunction. Patchouli alcohol (PA), a tricyclic sesquiterpene, is the major active constituent of Pogostemonis Herba. This study aimed to investigate the possible anti-ulcerogenic potential of PA and the underlying me...

journal_title：Chemico-biological interactions

authors： Zheng YF,Xie JH,Xu YF,Liang YZ,Mo ZZ,Jiang WW,Chen XY,Liu YH,Yu XD,Huang P,Su ZR

更新日期：2014-10-05 00:00:00

abstract：:In isolated frog heart it was established that methylene-blue (MB, an oxidizing agent) decreased, while ascorbate (ASC, a reducing agent) increased the frequency of autorhythmic heart contractions. After MB treatment, in parallel with this phenomenon, the extracellular K+ concentration [K+]o showed a slow increase, bu...

journal_title：Chemico-biological interactions

authors： Wittmann I,Puppi A,Dely M

更新日期：1987-01-01 00:00:00

abstract：:The hypolipidemic fibrates have been identified as agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha), which plays a critical role in the regulation of cardiac fatty acid metabolism. Despite the widespread clinical use of fibrates, their role in myocardial oxidative stress and fatty acid comp...

journal_title：Chemico-biological interactions

authors： Tian Q,Grzemski FA,Panagiotopoulos S,Ahokas JT

更新日期：2006-04-15 00:00:00

abstract：:The hydroquinone and catechol like metabolites, NCQ344 and NCQ436 respectively, of the antipsychotic remoxipride have recently been demonstrated to induce apoptosis in myeloperoxidase (MPO)-rich human bone marrow progenitor and HL-60 cells [S.M. McGuinness, R. Johansson, J. Lundstrom, D. Ross, Induction of apoptosis b...

journal_title：Chemico-biological interactions

authors： Inayat-Hussain SH,McGuinness SM,Johansson R,Lundstrom J,Ross D

更新日期：2000-08-15 00:00:00

abstract：:We had previously reported that the carcinogen, beta-propiolactone (BPL) reacted in vitro with histones in whole mouse skin chromatin and that among the histone classes BPL was preferentially bound to the lysine-rich histones H1 and H1 degrees. In order to determine if in vitro reaction of BPL with calf thymus histone...

journal_title：Chemico-biological interactions

authors： Segal A,Garte SJ

更新日期：1976-12-01 00:00:00

abstract：:Neutrophils from asymptomatic HIV-infected patients have an increased Nitroblue tetrazolium (NBT) reduction, that is an increased production of oxygen radicals. Plasma from these patients can activate normal neutrophils to an increased NBT-reduction and the neutrophil activating factor thus seems to be mainly plasma b...

journal_title：Chemico-biological interactions

authors： Jarstrand C,Akerlund B

更新日期：1994-06-01 00:00:00

abstract：:The apoptotic/necrotic changes in isolated human peripheral blood mononuclear cells (MNCs) subjected to hydrogen peroxide (H2O2), cyanate (NaOCN) and their combination were examined. The mitochondrial potential (ΔΨm), the activities of caspases (-2, -3, -6, -8 and -9) and the level of carbonyls and amino groups in pro...

journal_title：Chemico-biological interactions

authors： Pieniazek A,Gwozdzinski K

更新日期：2017-05-25 00:00:00

abstract：:Structure-uncoupling activity relationship of seven anthraquinone derivatives were investigated using rat liver mitochondria. Three compounds bearing the free hydroxyl group at the beta-position of their anthraquinone nucleus (1,3,6,8-tetrahydroxyanthraquinone, 1-acetyl-2,4,5,7-tetrahydroxy-9,10-anthracenedione and sk...

journal_title：Chemico-biological interactions

authors： Betina V,Kuzela S

更新日期：1987-01-01 00:00:00

abstract：:A new analysis of the quantitative structure-activity relationship (QSAR) of the antitumor activity of anilinoacridines against L1210 leukemia in mice and mouse toxicity is reported. QSAR have also been derived for the inhibitory activity of the anilinoacridines with tumor cells and their binding to DNA. These results...

journal_title：Chemico-biological interactions

authors： Gao H,Denny WA,Garg R,Hansch C

更新日期：1998-11-27 00:00:00