Human erythrocyte hemolysis induced by selenium and tellurium compounds increased by GSH or glucose: a possible involvement of reactive oxygen species.


:Oxidative stress can induce complex alterations of membrane proteins in red blood cells (RBCs) eventually leading to hemolysis. RBCs represent a good model to investigate the damage induced by oxidizing agents. Literature data have reported that chalcogen compounds can present pro-oxidant properties with potent inhibitory effects on cell growth, causing tissue damage and inhibit a variety of enzymes. In this study, human erythrocytes were incubated in vitro with various chalcogen compounds at 37 degrees C: diphenyl ditelluride (1), dinaphthalen diteluride (2), diphenyl diselenide (3), (S)-tert-butyl 1-diselenide-3-methylbutan-2-ylcarbamate (4), (S)-tert-butyl 1-diselenide-3-phenylpropan-2-ylcarbamate (5), selenium dioxide (6) and sodium selenite (7) in order to investigate their potential in vitro toxicity. After 6h of incubation, all the tested compounds increased the hemolysis rate, when compared to control and compound (2) had the most potent hemolytic effect. The addition of reduced glutathione (GSH) or glucose to the incubation medium enhanced hemolysis caused by chalcogen compounds. The thiol oxidase activity of these compounds was evaluated by measuring the rate of cysteine (CYS) and dithiotreitol (DTT) oxidation. DTT and cysteine oxidation was increased by all the compounds tested. The results suggest a relationship between the oxidation of intracellular GSH and subsequent generation of free radicals with the hemolysis by chalcogen compounds.


Chem Biol Interact


Schiar VP,Dos Santos DB,Paixão MW,Nogueira CW,Rocha JB,Zeni G




Has Abstract


2009-01-15 00:00:00














  • Resveratrol mitigate structural changes and hepatic stellate cell activation in N'-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage.

    abstract::Resveratrol, a polyphenol, found in skin of red grapes, peanuts and berries possesses anti-inflammatory, anti-carcinogenic and lipid modulation properties. Here, we demonstrate in vivo antifibrotic activity of resveratrol in a mammalian model, wherein hepatic fibrosis was induced by N'-nitrosodimethylamine (NDMA) admi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Ahmad A,Ahmad R

    更新日期:2014-09-25 00:00:00

  • Mercury inhibition of avian fatty acid synthetase complex.

    abstract::(1) Subcutaneous or intra-abdominal injections of 8 mg of HgCl2/100 g body weight markedly depressed hepatic fatty acid synthetase activity of chicks at 1 h post-injection. The depression occurred despite the fact that the chicks continued to eat up until the time they were killed. Under these same conditions, the hep...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Donaldson WE

    更新日期:1975-11-01 00:00:00

  • Differences in antioxidant potential of chalcones in human serum: In vitro study.

    abstract:INTRODUCTION:An imbalance between oxidants and antioxidants in favour of oxidants, potentially leading to damage, is termed oxidative stress. Antioxidants (AO), either enzymatic or non-enzymatic, are the ones that can reduce diverse effects of pro-oxidants such as DNA, proteins and lipids damage. Chalcones (1,3-diaryl-...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Janković T,Turković N,Kotur-Stevuljević J,Vujić Z,Ivković B

    更新日期:2020-06-01 00:00:00

  • In vitro and in vivo anticancer activity of posterior salivary gland toxin from the cuttlefish Sepia pharaonis, Ehrenberg (1831).

    abstract::Posterior salivary gland (PSG) toxins are high molecular weight toxins secreted by cephalopods and gastropods which possess immense potentials in biomedical applications. In the present study, the biomedical potentials of the PSG toxin from the cuttlefish, S. pharaonis was determined in vitro and in vivo. The cytostat...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Karthik R,Manigandan V,Ebenezar KK,Vijayashree R,Saravanan R

    更新日期:2017-06-25 00:00:00

  • Regulation and role of nuclear factor-E2-related factor 2 (Nrf2) in multidrug resistance of hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) chemoresistance, which is regarded as a kind of stress management reaction to chemotherapy drugs, severely hinders the therapy outcomes of HCC treatment. Stress management is generally achieved by activating certain signal pathways and chemical factors, among which, nuclear factor-E2-rel...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审


    authors: Tian B,Lu ZN,Guo XL

    更新日期:2018-01-25 00:00:00

  • Vasodilatory effect of nitroglycerin in Japanese subjects with different aldehyde dehydrogenase 2 (ALDH2) genotypes.

    abstract::The functional genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) influences the enzymatic activities of its wild type (Glu504 encoded by ALDH2*1) and mutant type (Lys504 encoded by ALDH2*2) proteins. The enzymatic activities of mutant-type ALDH2 are limited compared with those of the wild type. ALDH2 has been s...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Miura T,Nishinaka T,Terada T,Yonezawa K

    更新日期:2017-10-01 00:00:00

  • -116A and K BCHE gene variants associated with obesity and hypertriglyceridemia in adolescents from Southern Brazil.

    abstract::Butyrylcholinesterase (BChE) has been associated to body mass index (BMI), weight, cholesterol and triglyceride levels. -116A (rs1126680) and K (A539T, 1615A, rs1803274) BCHE gene variants had previously been associated to BChE activity, weight and BMI variance in adults. The present study examined -116A and K variant...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Chaves TJ,Leite N,Milano GE,Milano GE,Souza RL,Chautard-Freire-Maia EA,Furtado-Alle L

    更新日期:2013-03-25 00:00:00

  • Aspidin PB, a novel natural anti-fibrotic compound, inhibited fibrogenesis in TGF-β1-stimulated keloid fibroblasts via PI-3K/Akt and Smad signaling pathways.

    abstract::Keloid is an overgrowth of scar tissue that develops around a wound. The mechanisms of keloid formation and development still remain unknown, and no effective treatment is available. Searching for active natural resources may develop better prevention and treatment approaches for keloids. Aspidin PB is a natural resou...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Song R,Li G,Li S

    更新日期:2015-08-05 00:00:00

  • Spectral interactions of tetrachlorobiphenyls with hepatic microsomal cytochrome p450 enzymes.

    abstract::This study investigated the spectral interactions of hepatic microsomal cytochrome p450 (CYP) enzymes with four symmetrical polychlorinated biphenyls (PCBs): 2,2',4,4'-tetrachlorobiphenyl (PCB 47); 2,2',5,5'-tetrachlorobiphenyl (PCB 52); 2,2',6,6'-tetrachlorobiphenyl (PCB 54); and 3,3',4,4'-tetrachlorobiphenyl (PCB 77...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Hrycay EG,Bandiera SM

    更新日期:2003-12-15 00:00:00

  • Involvement of PI3K/Akt/GSK-3β signaling pathway in the antidepressant-like and neuroprotective effects of Morus nigra and its major phenolic, syringic acid.

    abstract::Depression is a common neuropsychiatric disorder whose pathophysiology has been associated with glutamatergic excitotoxicity. Thus, the research for new antidepressant strategies with the ability to mitigate glutamate toxicity has received growing attention. Given this background, the present study sought to investiga...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Dalmagro AP,Camargo A,Severo Rodrigues AL,Zeni ALB

    更新日期:2019-12-01 00:00:00

  • Inhibition of eukaryote protein kinases and of a cyclic nucleotide-binding phosphatase by prenylated xanthones.

    abstract::A series of prenylated xanthones are variously potent inhibitors of the catalytic subunit (cAK) of rat liver cyclic AMP-dependent protein kinase (PKA), rat brain Ca2+ and phospholipid-dependent protein kinase C (PKC), chicken gizzard myosin light chain kinase (MLCK), wheat embryo Ca2+-dependent protein kinase (CDPK) a...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Lu ZX,Hasmeda M,Mahabusarakam W,Ternai B,Ternai PC,Polya GM

    更新日期:1998-07-03 00:00:00

  • Lon protease and eiF2α are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells.

    abstract::Lon protease, an ATP dependent mitochondrial protease, is important in mitochondrial protein maintenance. Disruption of protein homeostasis and mitochondrial dysfunction is associated with lipodystrophy, metabolic syndrome and accelerated aging, and are commonly observed in patients on long term antiretroviral therapy...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Nagiah S,Phulukdaree A,Chuturgoon AA

    更新日期:2016-05-25 00:00:00

  • The tissue disposition and urinary excretion of cadmium, zinc, copper and iron, following repeated parenteral administration of cadmium to rats.

    abstract::The effect of repeated parenteral administration of cadmium (0.75, 1.5 and 3.0 mg/kg) on tissue disposition and urinary excretion of cadmium, zinc, copper and iron has been studied in the male rat. Cadmium, zinc and copper accumulated in liver and kidney, but the concentration of iron did not alter significantly. The ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Bonner FW,King LJ,Parke DV

    更新日期:1979-10-01 00:00:00

  • The bioactivation of 1,2-dibromoethane in rat hepatocytes: deuterium isotope effect.

    abstract::The metabolism and genotoxicity of 1,2-dibromoethane (EDB) and its deuterium substituted analog ( d4EDB ) were studied in isolated rat hepatocytes. There was a marked isotope effect on the metabolism of EDB by hepatocytes. This was due to decreased microsomal oxidation of d4EDB . Cytosolic metabolism of EDB, as measur...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: White RD,Petry TW,Sipes IG

    更新日期:1984-04-01 00:00:00

  • Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers.

    abstract::Acetylcholinesterase (AChE) terminates cholinergic neurotransmission by hydrolyzing acetylcholine. The collagen-tailed AChE tetramer is a product of 2 genes, ACHE and ColQ. The AChE tetramer consists of 4 identical AChE subunits and one polyproline-rich peptide, whose function is to hold the 4 AChE subunits together. ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Toker L,Silman I,Zeev-Ben-Mordehai T,Sussman JL,Schopfer LM,Lockridge O

    更新日期:2020-03-01 00:00:00

  • The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function.

    abstract::The stereospecific 5β-reduction of Δ(4)-3-ketosterols is very difficult to achieve chemically and introduces a 90° bend between ring A and B of the planar steroid. In mammals, the reaction is catalyzed by steroid 5β-reductase, a member of the aldo-keto reductase (AKR) family. The human enzyme, AKR1D1, plays an essenti...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,meta分析


    authors: Mindnich R,Drury JE,Penning TM

    更新日期:2011-05-30 00:00:00

  • Non-enzymatic ATP-mediated binding of hydroxymethyl derivatives of aromatic hydrocarbons to DNA.

    abstract::ATP mediates covalent binding of hydroxymethyl derivatives of aromatic hydrocarbons to DNA. This non-enzymatic reaction has been studied with 6-[14C]hydroxymethylbenzo[alpha]pyrene (]14C]BP-6-CH2OH) and 7-[14C]-hydroxymethylbenz[alpha]anthracene ([14C]BA-7-CH2OH) at 37 degrees C in Tris buffer (pH 7.0). While ADP medi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Rogan EG,Roth RW,Katomski-Beck PA,Laubscher JR,Cavalieri EL

    更新日期:1980-07-01 00:00:00

  • Influence of pH on the reactivity of diphenyl ditelluride with thiols and anti-oxidant potential in rat brain.

    abstract::Thiol oxidation by diphenyl ditelluride is a favorable reaction and may be responsible for alteration in regulatory or signaling pathways. We have measured rate constants for reactions of diphenyl ditelluride with cysteine, dimercaptosuccinic acid, glutathione and dithiothreitol in phosphate buffer. The relative react...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Hassan W,Ibrahim M,Nogueira CW,Braga AL,Deobald AM,Mohammadzai IU,Rocha JB

    更新日期:2009-06-15 00:00:00

  • Butyrylcholinesterase radioligands to image Alzheimer's disease brain.

    abstract::Butyrylcholinesterase (BuChE) is found to have a brain distribution pattern that is distinct from that of acetylcholinesterase (AChE). Neurons containing BuChE are particularly located in the amygdala, hippocampal formation and the thalamus, structures involved in the normal functions of cognition and behavior that ty...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Darvesh S

    更新日期:2013-03-25 00:00:00

  • The effects of benzoflavones on polycyclic hydrocarbon metabolism and skin tumor initiation.

    abstract::The effects of benzoflavones on skin tumor initiation by polycyclic hydrocarbons and epidermal aryl hydrocarbon hydroxylase were investigated. 7,8-Benzoflavone (7,8-BF) was found to be a potent inhibitor of the inhibition of skin tumors by 3-methylcholanthrene (MC) as well as 7,12-dimethylbenz(a)anthracene (DMBA). 5,6...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Slaga TJ,Thompson S,Berry DL,Digiovanni J,Juchau MR,Viaje A

    更新日期:1977-06-01 00:00:00

  • 1H-nuclear magnetic resonance of intercalators and rGCA: a potential mutagenicity probe.

    abstract::Variable temperature 1H-nuclear magnetic resonance (NMR) has been used to study the interaction of the RNA trimer, GpCpA, with the intercalators ethidium bromide and the acridine derivatives; proflavin, 9-amino-acridine, acridine orange, acridine yellow and acriflavin. The complexes formed were studied at nucleic acid...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Coddington JM,Alkema D,Bell RA,Hughes DW,Neilson T

    更新日期:1984-06-01 00:00:00

  • A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.

    abstract::The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflamma...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Wang Y,Wei Y,Oguntayo S,Doctor BP,Nambiar MP

    更新日期:2013-03-25 00:00:00

  • The effect of cephaloridine on the stability of rat kidney lysosomes.

    abstract::The administration of cephaloridine to rats caused a decrease in the excretion of acid phosphatase into the urine. The antibiotic itself had no effect on urinary acid phosphatase and inhibitors or proteolytic enzymes were not present in the urine from treated rats. Cephaloridine may therefore be stabilizing the lysoso...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Ngaha EO,Fry M,Plummer DT

    更新日期:1979-02-01 00:00:00

  • Camel milk attenuates the biochemical and morphological features of diabetic nephropathy: inhibition of Smad1 and collagen type IV synthesis.

    abstract::Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus (DM) that worsens its morbidity and mortality. There is evidence that camel milk (CM) improves the glycemic control in DM but its effect on the renal complications especially the DN remains unclear. Thus the current study aimed to ch...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Korish AA,Abdel Gader AG,Korashy HM,Al-Drees AM,Alhaider AA,Arafah MM

    更新日期:2015-03-05 00:00:00

  • A specific inhibitor of polo-like kinase 1, GSK461364A, suppresses proliferation of Raji Burkitt's lymphoma cells through mediating cell cycle arrest, DNA damage, and apoptosis.

    abstract::Polo-like kinase 1 (PLK1) is a prominent mediatory player during the cell cycle, mitosis, and cytokinesis in eukaryotic cells. Besides its physiological roles, PLK1 expression is upregulated in a wide range of human malignant tumors and its overexpression worsens prognosis, therefore, specific inhibition of PLK1 in tu...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Ergul M,Bakar-Ates F

    更新日期:2020-12-01 00:00:00

  • Protective effect of a novel cystine C(60) derivative on hydrogen peroxide-induced apoptosis in rat pheochromocytoma PC12 cells.

    abstract::Oxidative stress has been considered as a major cause of cellular injuries in a variety of clinical abnormalities, especially neural diseases. One of the effective ways to prevent the reactive oxygen species (ROS) mediated cellular injury is dietary or pharmaceutical augmentation of free radical scavengers. In the pre...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Hu Z,Guan W,Wang W,Huang L,Xing H,Zhu Z

    更新日期:2007-04-25 00:00:00

  • Vitamin D nanoemulsion enhances hepatoprotective effect of conventional vitamin D in rats fed with a high-fat diet.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is associated with hyperlipidemia, obesity and type II diabetes. Due to increasing prevalence of these diseases globally, NAFLD is considered as a common form of chronic liver diseases. Vitamin D is a fat soluble vitamin with reported anti-inflammatory, anti-oxidant ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: El-Sherbiny M,Eldosoky M,El-Shafey M,Othman G,Elkattawy HA,Bedir T,Elsherbiny NM

    更新日期:2018-05-25 00:00:00

  • The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents.

    abstract::Acetylcholinesterase (AChE) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. The reversible inhibition of AChE was suggested as the pre-treatment option of the intoxications caused by nerve agents. Based on our derived 3D-QSAR model ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Vitorović-Todorović MD,Worek F,Perdih A,Bauk SĐ,Vujatović TB,Cvijetić IN

    更新日期:2019-08-25 00:00:00

  • Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.

    abstract::In humans, the aldehyde dehydrogenase superfamily consists of 19 isoenzymes which mostly catalyze the NAD(P)(+)-dependent oxidation of aldehydes. Many of these isoenzymes have overlapping substrate specificities and therefore their potential physiological functions may overlap. Thus the development of new isoenzyme-se...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Buchman CD,Mahalingan KK,Hurley TD

    更新日期:2015-06-05 00:00:00

  • Amelioration effect of Egyptian sweet orange hesperidin on Ehrlich ascites carcinoma (EAC) bearing mice.

    abstract::There are global increased interests to identify novel agents that can possess anti-tumor effects or maximize the anti-tumor effects of low doses for conventional anti-cancer drugs. The aim of this study was to investigate anti-tumor effects and protective role of isolated hesperidin from sweet orange on doxorubicin-i...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Donia TIK,Gerges MN,Mohamed TM

    更新日期:2018-04-01 00:00:00