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Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid.

Abstract：

:Acetaminophen hepatotoxicity is characterized by extensive necrotic cell death and a sterile inflammatory response. A recent report suggested that a therapeutic intervention with chlorogenic acid, a dietary polyphenolic compound, protects against acetaminophen-induced liver injury by inhibiting the inflammatory injury. The purpose of this letter is to discuss a number of reasons why the protective mechanism of chlorogenic acid against acetaminophen hepatotoxicity does not involve an anti-inflammatory effect and provides an alternative explanation for the observed protection.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Jaeschke H

doi

10.1016/j.cbi.2015.08.025

subject

Has Abstract

pub_date

2016-01-05 00:00:00

pages

148-9

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(15)30053-3

journal_volume

243

pub_type

信件

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