Effect of enzyme inducers on metabolism of 1-nitropyrene in human hepatoma cell line HepG2.

abstract：:Exposure to metals and metalloids including arsenic, cadmium, mercury, and nickel has been a worldwide health problem for several decades. The aim of this study was to learn how metal-induced oxidative stress triggers cell proliferation, a process of great significance for cancer. NADPH oxidase (NOX) activity and cell...

journal_title：Chemico-biological interactions

authors： Mohammadi-Bardbori A,Rannug A

更新日期：2014-12-05 00:00:00

abstract：:Studies suggest iron overload may cause bone lesion. The mechanisms are not well understood at present. Therefore, this study was designed to observe the effect of iron overload on bone metabolism in young male rats and explore its possible mechanism. Eighteen SD rats were randomly assigned to iron-loading and control...

journal_title：Chemico-biological interactions

authors： Li Y,Bai B,Zhang Y

更新日期：2018-01-05 00:00:00

abstract：:Since aldose reductase is localized primarily in lens epithelial cells, osmotic insults induced by the accumulation of sugar alcohols occur first in these cells. To determine whether the accumulation of sugar alcohols can induce lens epithelial cell death, galactose-induced apoptosis has been investigated in dog lens ...

journal_title：Chemico-biological interactions

authors： Murata M,Ohta N,Sakurai S,Alam S,Tsai J,Kador PF,Sato S

更新日期：2001-01-30 00:00:00

abstract：:Posterior salivary gland (PSG) toxins are high molecular weight toxins secreted by cephalopods and gastropods which possess immense potentials in biomedical applications. In the present study, the biomedical potentials of the PSG toxin from the cuttlefish, S. pharaonis was determined in vitro and in vivo. The cytostat...

journal_title：Chemico-biological interactions

authors： Karthik R,Manigandan V,Ebenezar KK,Vijayashree R,Saravanan R

更新日期：2017-06-25 00:00:00

abstract：:The glyoxalase system is a metabolic pathway that catalyses the detoxification of alpha-oxoaldehydes RCOCHO to corresponding aldonic acids RCH(OH)CO2H. It thereby protects cells from alpha-oxoaldehyde-mediated formation of advanced glycation endproducts (AGEs). It is comprised of two enzymes, glyoxalase I and glyoxala...

journal_title：Chemico-biological interactions

authors： Thornalley PJ

更新日期：1998-04-24 00:00:00

abstract：:Keloid is an overgrowth of scar tissue that develops around a wound. The mechanisms of keloid formation and development still remain unknown, and no effective treatment is available. Searching for active natural resources may develop better prevention and treatment approaches for keloids. Aspidin PB is a natural resou...

journal_title：Chemico-biological interactions

authors： Song R,Li G,Li S

更新日期：2015-08-05 00:00:00

abstract：:Our laboratory has been routinely using suspended and cultured human hepatocytes for predicting drug metabolism and enzyme induction by drug candidates to aid drug discovery. Increasing limitation and irregular availability of human tissue has indicated the need for maximizing the use of this valuable resource. Cryopr...

journal_title：Chemico-biological interactions

authors： Silva JM,Day SH,Nicoll-Griffith DA

更新日期：1999-06-01 00:00:00

abstract：:Inhibition of microtubule assembly by arenastatin A (1) and five synthetic analogs (3-7) was examined. Arenastatin A and the triamide 6 showed potent and moderately strong inhibitory activities, respectively (IC50; 2.3 microM for 1, 7.8 microM for 6) and also depolymerized preformed microtubules. The other analogs tes...

journal_title：Chemico-biological interactions

authors： Koiso Y,Morita K,Kobayashi M,Wang W,Ohyabu N,Iwasaki S

更新日期：1996-12-20 00:00:00

abstract：:The formation and disappearance of DNA single-strand breaks (SSB) produced by 4-demethoxydaunorubicin (4-dmDR) in P388 murine leukemia cells and in a resistant subline were examined by alkaline elution methods in relation to cellular pharmacokinetics. DNA strand breaks produced by this intercalating agent were essenti...

journal_title：Chemico-biological interactions

authors： Capranico G,Tinelli S,Zunino F

更新日期：1989-01-01 00:00:00

abstract：:Little is known about the roles of aldehyde dehydrogenases in non-vertebrate animals. We recently showed that in Drosophila melanogaster, an enzyme with ∼70% amino acid identity to mammalian ALDH2 is necessary for detoxification of dietary ethanol. To investigate other functions of this enzyme, DmALDH, encoded by the ...

journal_title：Chemico-biological interactions

authors： Chakraborty M,Fry JD

更新日期：2011-05-30 00:00:00

abstract：:Selenium compounds such as methylseleninic acid (MSA) and sodium selenite (SS) have been widely evaluated as potential anti-cancer agents in the clinical setting. Primary effusion lymphoma (PEL) is a non-Hodgkin's B-cell lymphoma, associated with immunosuppressed individuals, such as post-transplant or AIDS patients. ...

journal_title：Chemico-biological interactions

authors： Shigemi Z,Manabe K,Hara N,Baba Y,Hosokawa K,Kagawa H,Watanabe T,Fujimuro M

更新日期：2017-03-25 00:00:00

abstract：:The mechanisms by which brassica vegetables might decrease the risk of cancer are reviewed in this paper. Brassicas, including all types of cabbages, broccoli, cauliflower and Brussels sprouts, may be protective against cancer due to their relatively high glucosinolate content. Glucosinolates are usually broken down t...

journal_title：Chemico-biological interactions

authors： Verhoeven DT,Verhagen H,Goldbohm RA,van den Brandt PA,van Poppel G

更新日期：1997-02-28 00:00:00

abstract：:The combined effects of ethanol and hypoxia on the conversion of xanthine dehydrogenase (D form) to xanthine oxidase (O form) and on the leakage of the enzyme from isolated rat hepatocytes was studied. Time-dependent death of cells occurred during incubation in hypoxic conditions. Ethanol (40 mM) had only a moderate e...

journal_title：Chemico-biological interactions

authors： Battelli MG,Abbondanza A,Stirpe F

更新日期：1992-06-15 00:00:00

abstract：:Human serum paraoxonase/arylesterase (PON1, EC 3.1.8.1.) is a calcium-dependent enzyme which hydrolyzes a wide variety of organophosphates, including paraoxon, DFP, sarin and soman. Although the 3-D structure of PON has not yet been determined and its sequence shows no similarity with any other crystallized proteins, ...

journal_title：Chemico-biological interactions

authors： Josse D,Xie W,Masson P,Lockridge O

更新日期：1999-05-14 00:00:00

abstract：:Accumulating data reveal that oroxylin A has beneficial effects against chronic liver disease. The previously studies showed oroxylin A, a flavonoid extracted from Scutellariae radix, improved acute liver injury and accelerated liver regeneration in vivo. However, it's unclear that the effect of oroxylin A on alcoholi...

journal_title：Chemico-biological interactions

authors： Jin H,Lian N,Bian M,Zhang C,Chen X,Shao J,Wu L,Chen A,Guo Q,Zhang F,Zheng S

更新日期：2018-04-01 00:00:00

abstract：:Several species of columnar cacti in the Sonoran Desert contain isoquinoline alkaloids that are toxic to all but the resident drosophilids that feed and breed in necrotic stems. Cytochrome P450 enzymes are known to be involved in the metabolic detoxification of these alkaloids by the desert Drosophila and are conseque...

journal_title：Chemico-biological interactions

authors： Fogleman JC

更新日期：2000-03-01 00:00:00

abstract：:Resveratrol, a polyphenol, found in skin of red grapes, peanuts and berries possesses anti-inflammatory, anti-carcinogenic and lipid modulation properties. Here, we demonstrate in vivo antifibrotic activity of resveratrol in a mammalian model, wherein hepatic fibrosis was induced by N'-nitrosodimethylamine (NDMA) admi...

journal_title：Chemico-biological interactions

authors： Ahmad A,Ahmad R

更新日期：2014-09-25 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a tea polyphenol, inhibits the proliferation of many cancer cell lines; however, the antiproliferative mechanism(s) are not well-characterized. The objective of this study is to identify the cellular signaling mechanism(s) responsible for the antiproliferative effects of EGCG in the ...

journal_title：Chemico-biological interactions

authors： Albrecht DS,Clubbs EA,Ferruzzi M,Bomser JA

更新日期：2008-01-10 00:00:00

abstract：:Treatment of animals with hydrazine causes the accumulation of triglycerides in the liver but the mechanism remains unclear. Therefore, the effect of hydrazine on hepatic triglyceride synthesis and subsequent transport was studied in a hepatocyte model, in vitro in order to isolate liver cells from extrahepatic influe...

journal_title：Chemico-biological interactions

authors： Waterfield CJ,Asker DS,Timbrell JA

更新日期：1997-11-28 00:00:00

abstract：:Proteolysis and lipid peroxidation were evaluated in rat liver slices incubated in the presence of the oxidant bromotrichloromethane and effectors of proteolysis. Proteolysis was evaluated by S-amino acids and lipid peroxidation by thiobarbituric acid-reactive substances (TBARS) released into the incubation medium. Th...

journal_title：Chemico-biological interactions

authors： Zamora R,Hidalgo FJ,Tappel AL

更新日期：1990-01-01 00:00:00

abstract：:We have directly compared in resting human mononuclear leukocytes the DNA repair effects caused by ADP-ribosyl transferase (ADPRT) activity following DNA damage induction by gamma radiation, UV radiation, ethylene oxide (EO) and N-acetoxy-2-acetylaminofluorene (NA-AAF). The presence of inhibitors of ADPRT during the q...

journal_title：Chemico-biological interactions

authors： Pero RW,Jonsson GG,Persson L

更新日期：1983-12-01 00:00:00

abstract：:Experiments were conducted on the effects of various dose levels of benzo [a]pyrene (BP) on nuclear size in mouse interfollicular epidermis over a 3-day period. Topical application of BP was made with or without croton oil (CO) (0.1 or 0.5%) in the vehicles acetone, toluene and methyl ethyl ketone (MEK). Nuclear size ...

journal_title：Chemico-biological interactions

authors： Ingram AJ

更新日期：1979-06-01 00:00:00

abstract：:A multi-compartment physiologically based pharmacokinetic (PBPK) model was developed to describe the behavior of Cr(III) and Cr(VI) in rats and mice following long-term oral exposure. Model compartments were included for GI lumen, oral mucosa, forestomach/stomach, small intestinal mucosa (duodenum, jejunum, ileum), bl...

journal_title：Chemico-biological interactions

authors： Kirman CR,Hays SM,Aylward LL,Suh M,Harris MA,Thompson CM,Haws LC,Proctor DM

更新日期：2012-10-25 00:00:00

abstract：:Macrophages and inflammasome pathway are involved in high-glucose toxicity and development of insulin resistance. Silymarin (SMR) was known to modulate glucose homeostasis and reduce inflammation. However, it is still unknown whether SMR possess anti-hyperglycemic effects in diabetic-like knockout mice (Hnf-1αkin/-/In...

journal_title：Chemico-biological interactions

authors： Lu CP,Huang CY,Wang SH,Chiu CH,Li LH,Hua KF,Wu TH

更新日期：2018-06-25 00:00:00

abstract：:The cytostatic drug 6-mercaptopurine riboside (6-MPr) was investigated in mice in order to test the hypothesis that the teratogenicity of this antimetabolite is paralleled by an incorporation into the DNA of the embryos during organogenesis. DNA modification in the embryos was analysed 4 h following s.c. administratio...

journal_title：Chemico-biological interactions

authors： Platzek T,Schwabe R,Rahm U,Bochert G

更新日期：1994-10-01 00:00:00

abstract：:Exposure to perfluorocarboxylic acids, pthalate esters, and some hypolipidemic agents results in the proliferation of peroxisomes in the rodent liver. The structural diversity of these compounds suggests mechanistic diversity in their toxicity as well. To establish reliable biomarkers of peroxisome proliferation (PP) ...

journal_title：Chemico-biological interactions

authors： Witzmann F,Coughtrie M,Fultz C,Lipscomb J

更新日期：1996-01-05 00:00:00

abstract：:Studies were undertaken to investigate the mechanism of bioactivation and covalent binding of TNT. Incubation of [14C]TNT with rat liver microsomes in the presence of an NADPH generating system resulted in metabolism and covalent binding to microsomal proteins. Time-dependence studies showed that TNT was rapidly reduc...

journal_title：Chemico-biological interactions

authors： Leung KH,Yao M,Stearns R,Chiu SH

更新日期：1995-06-30 00:00:00

abstract：:The structure of the covalent adduct formed in vitro between [14C]-acetaminophen ([14C]APAP) and bovine serum albumin (BSA) has been investigated with the aid of new analytical methodology. The APAP-BSA adduct, isolated from mouse liver microsomal incubations to which the radiolabeled drug and BSA had been added, was ...

journal_title：Chemico-biological interactions

authors： Hoffmann KJ,Streeter AJ,Axworthy DB,Baillie TA

更新日期：1985-02-01 00:00:00

abstract：:Acetaminophen hepatotoxicity is characterized by extensive necrotic cell death and a sterile inflammatory response. A recent report suggested that a therapeutic intervention with chlorogenic acid, a dietary polyphenolic compound, protects against acetaminophen-induced liver injury by inhibiting the inflammatory injury...

journal_title：Chemico-biological interactions

authors： Jaeschke H

更新日期：2016-01-05 00:00:00

abstract：:The administration of cephaloridine to rats caused a decrease in the excretion of acid phosphatase into the urine. The antibiotic itself had no effect on urinary acid phosphatase and inhibitors or proteolytic enzymes were not present in the urine from treated rats. Cephaloridine may therefore be stabilizing the lysoso...

journal_title：Chemico-biological interactions

authors： Ngaha EO,Fry M,Plummer DT

更新日期：1979-02-01 00:00:00