Unscheduled DNA synthesis induced by N-acetoxy-2-acetylaminofluorene is not sensitive to regulation by ADP-ribosyl transferase.

abstract：:The on-going pandemic of COVID-19 wreaked by a viral infection of SARS-CoV-2, has generated a catastrophic plight across the globe. Interestingly, one of the hallmarks of COVID-19 is the so-called 'cytokine storm' due to attack of SARS-Cov-2 in the lungs. Considering, mesenchymal stem cells (MSCs) therapy could contri...

journal_title：Chemico-biological interactions

authors： Dubey AK,Singh A,Prakash S,Kumar M,Singh AK

更新日期：2020-12-01 00:00:00

abstract：:Interest in organoselenide chemistry and biochemistry has increased in the past three decades, mainly due to their chemical and biological activities. Here, we investigated the protective effect of the organic selenium compound diphenyl diselenide (PhSe)2 (5 μmol/kg), in a mouse model of methylmercury (MeHg)-induced b...

journal_title：Chemico-biological interactions

authors： Glaser V,Moritz B,Schmitz A,Dafré AL,Nazari EM,Rauh Müller YM,Feksa L,Straliottoa MR,de Bem AF,Farina M,da Rocha JB,Latini A

更新日期：2013-10-25 00:00:00

abstract：:The molecular biology and enzymology of aldehyde dehydrogenase (ALDH) have been extensively investigated. However, most of the studies have been confined to the mammalian forms, while the sub-mammalian vertebrate ALDHs are relatively unexplored. In the present investigation, an ALDH was purified from the hepatopancrea...

journal_title：Chemico-biological interactions

authors： Fong W,Choy K

更新日期：2001-01-30 00:00:00

abstract：:In the present study, we examined the effects of hemin on the mutagenicity of 6-sulfooxymethylbenzo[a]pyrene (SMBP) in Salmonella typhimurium TA98 and Chinese hamster lung fibroblast (V79) cells. The compound was tested for the possible chemoprotective activity against mutagenesis induced by SMBP and its precursor, 6-...

journal_title：Chemico-biological interactions

authors： Hong ST,Cho YS,Surh YJ,Chung AS

更新日期：1998-02-20 00:00:00

abstract：:Sulfation and sulfate conjugate hydrolysis play an important role in metabolism, and are catalysed by members of the sulfotransferase and sulfatase enzyme super-families. In general, sulfation is a deactivating, detoxication pathway, but for some chemicals the sulfate conjugates are much more reactive than the parent ...

journal_title：Chemico-biological interactions

authors： Coughtrie MW,Sharp S,Maxwell K,Innes NP

更新日期：1998-02-20 00:00:00

abstract：:2-Nitropropane (2-NP) is a genotoxicant and hepatocarcinogen in rodents. Conversion to propane 2-nitronate (P2N), the anion of the tautomeric aci form of 2-NP, seems to be a pivotal part of the mechanism by which 2-NP causes its toxicity. We tested the hypothesis that the tautomeric equilibrium is influenced by enzyme...

journal_title：Chemico-biological interactions

authors： Kohl C,Gescher A

更新日期：1996-01-05 00:00:00

abstract：:Glycidyl ethers are used in epoxy resins. Epoxy resins are widely used in adhesives and coatings, as well as in electronics and structural composites, thus there is a potential of human exposure to glycidyl ethers. The aim of the present investigation was to explore the utility of haemoglobin adducts for biomonitoring...

journal_title：Chemico-biological interactions

authors： Pérez HL,Plná K,Osterman-Golkar S

更新日期：1997-01-24 00:00:00

abstract：:The distribution and metabolism of the environmental pollutant 1-nitropyrene was studied in C57B1/6N mice following oral or intraperitoneal dosing. When administered by gavage, 1-nitropyrene and its metabolites demonstrated biphasic elimination kinetics from the blood, with half-lives of 0.3 and 1.8 days and a distrib...

journal_title：Chemico-biological interactions

authors： Howard PC,Consolo MC,Dooley KL,Beland FA

更新日期：1995-04-14 00:00:00

abstract：:The distribution of 203Hg after inhalation of radioactive metallic mercury (4.3 mumol 203Hg0/kg body wt. for 1 h) was studied in saline (control) and selenite (10 mumol/kg body wt. intraperitoneally, i.p.) pretreated male C57BL mice by means of whole-body autoradiography and scintillation counting. Selenite pretreatme...

journal_title：Chemico-biological interactions

authors： Khayat A,Dencker L

更新日期：1983-09-15 00:00:00

abstract：:Unscheduled DNA synthesis (UDS), following exposure to dimethylnitrosamine (DMN), was potentiated in cultured hepatocytes isolated following treatment of rats for 14 or 28 days with 20% ethanol/5% sucrose solution. Ethanol treatment was associated with increased UDS, a concomitant increase in hepatic microsomal protei...

journal_title：Chemico-biological interactions

authors： Olson MJ,Pounds JG,Casciano DA

更新日期：1984-08-01 00:00:00

abstract：:Lanthanides (Ln) were known to induce cell apoptosis, which might be the results of their effects on mitochondria (MT). This study was trying to clarify the role of MT and reactive oxygen species (ROS) in Ln-induced apoptosis. We found that micromolar or lower concentration of La(3+), Gd(3+) and Yb(3+) bound to MT and...

journal_title：Chemico-biological interactions

authors： Liu H,Yuan L,Yang X,Wang K

更新日期：2003-07-25 00:00:00

abstract：:Anopheles gambiae is the major mosquito vector of malaria in sub-Saharan Africa. At present, insecticide-treated nets (ITNs) impregnated with pyrethroid insecticides are widely used in malaria-endemic regions to reduce infection; however the emergence of pyrethroid-resistant mosquitoes has significantly reduced the ef...

journal_title：Chemico-biological interactions

authors： Carlier PR,Anderson TD,Wong DM,Hsu DC,Hartsel J,Ma M,Wong EA,Choudhury R,Lam PC,Totrov MM,Bloomquist JR

更新日期：2008-09-25 00:00:00

abstract：:Ultraviolet absorption data and thermal chromatography through hydroxyapatite (HAP) column revealed that furazolidone treatment of Vibrio cholerae cells produced more than 80% of DNA reversibly bihelical due to the formation of interstrand cross-links and the reaction obeyed a first order relation. Sensitivities of th...

journal_title：Chemico-biological interactions

authors： Chatterjee SN,Banerjee SK,Pal AK,Basak J

更新日期：1983-08-01 00:00:00

abstract：:Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhiz...

journal_title：Chemico-biological interactions

authors： Song N,Zhao Z,Ma X,Sun X,Ma J,Li F,Sun L,Lv J

更新日期：2017-01-05 00:00:00

abstract：:1. The cytotoxicity of N-nitrosomethylaniline (NMA) towards hepatocytes isolated from rats was prevented by acetone or ethanol (inhibitors for cytochrome P-450IIE1) but not by metyrapone or SKF525A (inhibitors for cytochrome P-450IIB1/2). Various alcohols, secondary ketones and isothiocyanates that induced cytochrome ...

journal_title：Chemico-biological interactions

authors： Quan Z,Khan S,O'Brien PJ

更新日期：1992-08-28 00:00:00

abstract：:Chronic exposure of humans to benzene causes severe bone marrow cell depression leading to aplastic anemia. Marrow stromal macrophage dysfunction and deficient interleukin-1 production has been reported for patients with severe aplastic anemia. The stromal macrophage, a target of benzene toxicity, is involved in hemat...

journal_title：Chemico-biological interactions

authors： Niculescu R,Bradford HN,Colman RW,Kalf GF

更新日期：1995-12-22 00:00:00

abstract：:Two diol epoxides of benzo(a)pyrene (BP), and benzo(a)pyrene 4,5-oxide, have been used to make adducts in the homopolymers polyribocytidylic acid, (rC); polyriboadenylic acid (rA), polydeoxycytidylic acid (dC) and polydeoxyadenylic acid (dA). With appropriate oligomers as primers these modified and unmodified polynucl...

journal_title：Chemico-biological interactions

authors： Yamaura I,Marquardt H,Cavalieri LF

更新日期：1978-12-01 00:00:00

abstract：:Protocatechuic acid (PCA; 3, 4-dihydroxybenzoic acid) is a phenolic compound widely found in many edible fruits, vegetables, grape wine and plant-derived beverages. The present study investigated the impact of PCA on the hypothalamic-pituitary-testicular axis of rats orally treated with PCA during the period of prepub...

journal_title：Chemico-biological interactions

authors： Adedara IA,Omole O,Okpara ES,Fasina OB,Ayeni MF,Ajayi OM,Busari EO,Farombi EO

更新日期：2018-06-25 00:00:00

abstract：:Ethanol abuse is a serious public health problem that is associated with several stages of alcoholic liver disease (ALD) and a high incidence of morbidity and mortality. Alcoholic fatty liver disease (AFLD), the earliest stage of ALD, is a multifactorial injury that involves oxidative stress and disruptions of lipid m...

journal_title：Chemico-biological interactions

authors： Lívero FA,Martins GG,Queiroz Telles JE,Beltrame OC,Petris Biscaia SM,Cavicchiolo Franco CR,Oude Elferink RP,Acco A

更新日期：2016-12-25 00:00:00

abstract：:The unwinding of superhelical Col E1-DNA was studied by means of gel electrophoresis and electron microscopy after covalent binding of N-acetoxy-N-2-[14C]acetylaminofluorene (N-Aco-[14C]AAF) and its 7-iodo derivative (N-Aco-[14C]AAIF). Studies with both compounds indicated that complete unwinding of the supercoiled DN...

journal_title：Chemico-biological interactions

authors： Lang MC,Freund AM,de Murcia G,Fuchs RP,Daune MP

更新日期：1979-12-01 00:00:00

abstract：:A chromatographic procedure for improved separation of deoxyribonucleosides and methylated deoxyribonucleosides is described. DNA was isolated from liver and small intestine of rats treated with [14C]dimethylnitrosamine ([14C]DMN) or N-[3H]methyl-N-nitrosourea ([3H]MNU), and the purified DNA was hydrolyzed enzymatical...

journal_title：Chemico-biological interactions

authors： Daoud AH,Irving CC

更新日期：1977-02-01 00:00:00

abstract：:Our laboratory has been routinely using suspended and cultured human hepatocytes for predicting drug metabolism and enzyme induction by drug candidates to aid drug discovery. Increasing limitation and irregular availability of human tissue has indicated the need for maximizing the use of this valuable resource. Cryopr...

journal_title：Chemico-biological interactions

authors： Silva JM,Day SH,Nicoll-Griffith DA

更新日期：1999-06-01 00:00:00

abstract：:An updated biokinetic model for human exposures to cobalt (Co) was developed based on a comprehensive set of human pharmacokinetics data collected from five male and five female volunteers who ingested ∼1 mg Co/day of a Co supplement for 3 months. Three key experimental observations from the human dosing studies were ...

journal_title：Chemico-biological interactions

authors： Unice KM,Kerger BD,Paustenbach DJ,Finley BL,Tvermoes BE

更新日期：2014-06-05 00:00:00

abstract：:Ferulago macrocarpa (Fenzl) Boiss., is an endemic medicinal herb of Iran. In this study a dihydrofuranocoumarin called grandivittin (GRA) was separate and purified from Ferulago macrocarpa (Fenzl) Boiss, and characterized by (1)H NMR and Mass spectroscopic methods. The electrochemical behavior of GRA was evaluated by ...

journal_title：Chemico-biological interactions

authors： Ahmadi F,Valadbeigi S,Sajjadi SE,Shokoohinia Y,Azizian H,Taheripak G

更新日期：2016-10-25 00:00:00

abstract：:Evidence for the reversible binding of paraquat to calf thymus DNA has been obtained using equilibrium dialysis and thermal melting point determinations. The data indicated the presence of at least two populations of binding site with affinity constants of 6.2 X 10(4) and 7.1 X 10(3) M-1, respectively. The binding cap...

journal_title：Chemico-biological interactions

authors： Minchin RF

更新日期：1987-02-01 00:00:00

abstract：:The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new treatments for human diseases. Previous studies have reported polyphosphate (PolyP)-mediated vascular inflammatory responses such as disruption of vascular integrity. Dabrafenib is a B-Raf...

journal_title：Chemico-biological interactions

authors： Lee S,Ku SK,Bae JS

更新日期：2016-08-25 00:00:00

abstract：:The mechanisms by which brassica vegetables might decrease the risk of cancer are reviewed in this paper. Brassicas, including all types of cabbages, broccoli, cauliflower and Brussels sprouts, may be protective against cancer due to their relatively high glucosinolate content. Glucosinolates are usually broken down t...

journal_title：Chemico-biological interactions

authors： Verhoeven DT,Verhagen H,Goldbohm RA,van den Brandt PA,van Poppel G

更新日期：1997-02-28 00:00:00

abstract：:Wild-type human butyrylcholinesterase (BuChE) has proven to be an efficient bioscavenger for protection against nerve agent toxicity. Human acetylcholinesterase (AChE) has a similar potential. A limitation to their usefulness is that both cholinesterases (ChEs) react stoichiometrically with organophosphosphorus (OP) e...

journal_title：Chemico-biological interactions

authors： Masson P,Nachon F,Broomfield CA,Lenz DE,Verdier L,Schopfer LM,Lockridge O

更新日期：2008-09-25 00:00:00

abstract：:Inflammation, oxidative stress and altered mucosal barrier permeability are potential etiopathological or triggering factors for inflammatory bowel disease (IBD). In this study, the therapeutic potential of Mangiferin was investigated in vivo in mouse model of colitis and also attempts were made to understand mechanis...

journal_title：Chemico-biological interactions

authors： Somani S,Zambad S,Modi K

更新日期：2016-06-25 00:00:00

abstract：:A cellular model of cardiomyocytes (H9c2 cell line) and mitochondria isolated from mouse liver were used to understand the drug action of BPDZ490 and BPDZ711, two benzopyran analogues of the reference potassium channel opener cromakalim, on mitochondrial respiratory parameters and swelling, by comparing their effects ...

journal_title：Chemico-biological interactions

authors： Mouithys-Mickalad A,Ceusters J,Charif M,El Moualij B,Schoumacher M,Plyte S,Franck T,Bettendorff L,Pirotte B,Serteyn D,de Tullio P

更新日期：2020-11-01 00:00:00