DNA damage, prophage induction and mutation by furazolidone.

Abstract:

:Ultraviolet absorption data and thermal chromatography through hydroxyapatite (HAP) column revealed that furazolidone treatment of Vibrio cholerae cells produced more than 80% of DNA reversibly bihelical due to the formation of interstrand cross-links and the reaction obeyed a first order relation. Sensitivities of the Escherichia coli strains to the lethal action of the drug were in the order: AB 2480(uvr- rec-) greater than AB 2463(rec-) greater than AB 1886(uvr-) greater than AB 1157(repair proficient) or AB 4401(wild type). Furazolidone was 'Rec test' positive, produced dose-dependent prophage induction in E. coli cells and also dose-dependent streptomycin-resistance forward mutation in V. cholerae cells. The quantitative aspect and also the mode of furazolidone action on DNA were discussed.

journal_name

Chem Biol Interact

authors

Chatterjee SN,Banerjee SK,Pal AK,Basak J

doi

10.1016/0009-2797(83)90078-9

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

315-26

issue

3

eissn

0009-2797

issn

1872-7786

pii

0009-2797(83)90078-9

journal_volume

45

pub_type

杂志文章
  • Drosophila lacking a homologue of mammalian ALDH2 have multiple fitness defects.

    abstract::Little is known about the roles of aldehyde dehydrogenases in non-vertebrate animals. We recently showed that in Drosophila melanogaster, an enzyme with ∼70% amino acid identity to mammalian ALDH2 is necessary for detoxification of dietary ethanol. To investigate other functions of this enzyme, DmALDH, encoded by the ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2011.01.031

    authors: Chakraborty M,Fry JD

    更新日期:2011-05-30 00:00:00

  • Characterization of reaction products between styrene oxide and deoxynucleosides and DNA.

    abstract::Styrene oxide was reacted with deoxynucleosides and DNA in aqueous buffer at pH 7.4. The products were purified by HPLC, characterized by UV spectroscopy and by chemical ionization mass spectrometry. The main products identified were 7-alkyl-, N2-alkyl- and O6-alkyldeoxyguanosine, 1-alkyl-, and N6-alkyldeoxyadenosine,...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(86)90055-4

    authors: Savela K,Hesso A,Hemminki K

    更新日期:1986-12-01 00:00:00

  • Transport routes of metalloids into and out of the cell: a review of the current knowledge.

    abstract::Except for their extra- and intra-cellular interfaces, cell membranes are hydrophobic and inhibit the transport of hydrophilic molecules. Metalloids in aqueous solutions form chemical species with oxygen and hydroxyl groups and, therefore, exist as hydrophilic neutral polar solutes or as hydrophilic anions. This chara...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbi.2012.02.001

    authors: Zangi R,Filella M

    更新日期:2012-04-15 00:00:00

  • A synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), triggers reactive oxygen species-induced apoptosis independently of p53 in A549 lung cancer cells.

    abstract::2-Hydroxy-3',5,5'-trimethoxychalcone (named DK-139) is a synthetic chalcone derivative that has anti-inflammatory, anti-tumor, and endoplasmic reticulum-mediated apoptosis activities. However, the mode of action of DK-139 on reactive oxygen species (ROS)-induced apoptosis remains unknown. In this study, we found that ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2018.11.003

    authors: Gil HN,Jung E,Koh D,Lim Y,Lee YH,Shin SY

    更新日期:2019-01-25 00:00:00

  • Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2α biosynthesis and action in ovarian endometriosis tissue and in model cell lines.

    abstract::Endometriosis is a frequent benign gynecological disease characterized by endometrial tissue outside the uterine cavity. The estimated prevalence in the general population is 6-10%, but this reaches 30-50% in women with infertility and/or pain. As ectopic tissue within the pelvic cavity provokes inflammation, endometr...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2014.11.009

    authors: Sinreih M,Anko M,Kene NH,Kocbek V,Rižner TL

    更新日期:2015-06-05 00:00:00

  • Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes.

    abstract::Drug induced liver injury (DILI), a major cause of pre- and post-approval failure, is challenging to predict pre-clinically due to varied underlying direct and indirect mechanisms. Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) and Ritonavir, a protease inhibitor, are antiviral drugs that cause c...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2015.11.023

    authors: Terelius Y,Figler RA,Marukian S,Collado MS,Lawson MJ,Mackey AJ,Manka D,Qualls CW Jr,Blackman BR,Wamhoff BR,Dash A

    更新日期:2016-08-05 00:00:00

  • Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease.

    abstract:OBJECTIVES:Oxidative stress is one component of alcoholic liver disease (ALD) that is manifested in the peroxidation of cellular lipids producing the electrophile, 4-hydroxynonenal (4-HNE). This electrophile is proposed to modify essential cellular proteins resulting in loss of protein function and cellular homeostasis...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbi.2011.02.021

    authors: Smathers RL,Galligan JJ,Stewart BJ,Petersen DR

    更新日期:2011-06-30 00:00:00

  • The time course of DNA repair following methyl nitro-nitrosoguanidine (MNNG) treatment of p388f lymphoma cells in culture. II. DNA repair synthesis and its correlation with strand breakage.

    abstract::Repair synthesis has been followed in P388F cell DNA following treatment with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) using 5-iodo-deoxyuridine (IUdR) and [3H] thymidine combination. A pattern of repair synthesis was obtained, similar in its timing to the initial and medial stages of single-strand break formation ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(76)90023-5

    authors: Nikaido O,Fox BW

    更新日期:1976-07-01 00:00:00

  • DNA damage and DNA repair in cultured human cells exposed to chromate.

    abstract::DNA damage and DNA repair have been observed in cultured human skin fibroblasts exposed to potassium chromate but not to a chromic glycine complex. DNA repair synthesis (unscheduled incorporation of [3H]thymidine (TdR)) was measured in cells during or following exposure to chromate and was significant for chromate con...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(79)90030-9

    authors: Whiting RF,Stich HF,Koropatnick DJ

    更新日期:1979-08-01 00:00:00

  • Oxidative stress decreases extracellular homocysteine concentration in human hepatoma (HepG2) cell cultures.

    abstract:BACKGROUND:Mild hyperhomocysteinemia is associated with premature vascular disease. The mechanism behind the vascular injuries is, however, still unknown. Homocysteine may be catabolized in the trans-sulfuration pathway to cysteine. Cystathionine beta-synthase, which catalyses the first step in the trans-sulfuration pa...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2006.10.009

    authors: Hultberg M,Hultberg B

    更新日期:2007-01-05 00:00:00

  • Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions.

    abstract::Risperidone has been used in some stress disorders and may be potentially protective against stress-induced gastric lesions. Thus, the aim of the present study is to investigate, whether risperidone, a D(2) receptor and 5-HT(2A) receptor antagonist, would be able to result in gastroprotective effect in stress-induced ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2011.02.002

    authors: Saxena B,Krishnamurthy S,Singh S

    更新日期:2011-04-25 00:00:00

  • Exploring the interaction of silver nanoparticles with pepsin and its adsorption isotherms and kinetics.

    abstract::The interaction of nanoparticles (NPs) with proteins is a topic of high relevance for the medical application of nanomaterials. In the study, a comprehensive investigation was performed for the binding properties of silver nanoparticles (AgNPs) to pepsin. The results indicate that the binding of AgNPs to pepsin may be...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2018.03.004

    authors: Li X,Wang K,Peng Y

    更新日期:2018-04-25 00:00:00

  • The 3,4-oxide is responsible for the DNA binding of benzo[ghi]perylene, a polycyclic aromatic hydrocarbon without a "classic" bay-region.

    abstract::The polycyclic aromatic hydrocarbon (PAH) benzo[ghi]perylene (BghiP) lacks a "classic" bay-region and is therefore unable to form vicinal dihydrodiol epoxides thought to be responsible for the genotoxicity of carcinogenic PAHs like benzo[a]pyrene. The bacterial mutagenicity of BghiP increases considerably after inhibi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2008.07.010

    authors: Platt KL,Grupe S,Fickler M

    更新日期:2008-11-25 00:00:00

  • Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.

    abstract::The mechanisms by which soybean- and soybean isoflavone-enriched diets inhibit carcinogenesis are not known. We found that the isoflavones genistin and daidzin, and their respective aglucone forms daidzein and genistein, block 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin)-induced CYP1A1 enzyme activity. This inhi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/s0009-2797(99)00121-0

    authors: Shertzer HG,Puga A,Chang C,Smith P,Nebert DW,Setchell KD,Dalton TP

    更新日期:1999-11-15 00:00:00

  • Chromatographic resolution of amino acid adducts of aliphatic halides.

    abstract::Numerous xenobiotics are known to be bioactivated and to covalently and to proteins, but the resulting amino acid adducts (AAAs) are unknown. In this study the AAAs of twelve 14C-labeled aliphatic halides were examined after formation in an in vitro microsomal system. After exhaustive solvent extraction of the precipi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(82)90038-2

    authors: Maiorino RM,Gandolfi AJ,Brendel K,Mac Donald JR,Sipes IG

    更新日期:1982-01-01 00:00:00

  • Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes.

    abstract::Numerous reactive oxygen species (ROS) and reactive carbonyl species (RCS) issuing from lipid and sugar oxidation are known to damage a large number of proteins leading to enzyme inhibition and alteration of cellular functions. Whereas studies in literature only focus on the reactivity of one or two of these compounds...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2010.12.028

    authors: Lesgards JF,Gauthier C,Iovanna J,Vidal N,Dolla A,Stocker P

    更新日期:2011-03-15 00:00:00

  • Refined biokinetic model for humans exposed to cobalt dietary supplements and other sources of systemic cobalt exposure.

    abstract::An updated biokinetic model for human exposures to cobalt (Co) was developed based on a comprehensive set of human pharmacokinetics data collected from five male and five female volunteers who ingested ∼1 mg Co/day of a Co supplement for 3 months. Three key experimental observations from the human dosing studies were ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2014.04.001

    authors: Unice KM,Kerger BD,Paustenbach DJ,Finley BL,Tvermoes BE

    更新日期:2014-06-05 00:00:00

  • S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis.

    abstract::Endocrine therapies (e.g. tamoxifen and aromatase inhibitors) targeting estrogen action are effective in decreasing mortality of breast cancer. However, their efficacy is limited by intrinsic and acquired resistance. Our previous study demonstrated that overexpression of a histone methyltransferase NSD2 drives tamoxif...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2020.108965

    authors: Wang Q,Zheng J,Zou JX,Xu J,Han F,Xiang S,Liu P,Chen HW,Wang J

    更新日期:2020-02-01 00:00:00

  • A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.

    abstract::The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflamma...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2012.10.016

    authors: Wang Y,Wei Y,Oguntayo S,Doctor BP,Nambiar MP

    更新日期:2013-03-25 00:00:00

  • Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-kappaB pathway: role of a novel plant protein.

    abstract::Oxidative stress is a major cause of drug induced hepatic diseases. The present study aims to investigate the antioxidative signaling mechanism of a protein isolated from the herb, Cajanus indicus against acetaminophen induced necrotic cell death. We found that incubation of hepatocytes with the protein prevented acet...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2008.09.006

    authors: Ghosh A,Sil PC

    更新日期:2009-01-27 00:00:00

  • Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment.

    abstract::Current regulatory practices for chemical carcinogens were established when scientific understanding of the molecular mechanisms of chemical carcinogenesis was in its infancy. Initial discovery that DNA mutation was the root of cancer led quickly to regulatory processes that assumed such a simple relationship could be...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbi.2019.01.025

    authors: Clewell RA,Thompson CM,Clewell HJ 3rd

    更新日期:2019-03-01 00:00:00

  • Tissue oxidative damage mediates impairment on phosphotransfer network during thymol intake: Effects on hepatic and renal bioenergetics.

    abstract::Recent evidences demonstrated that ingestion of several monoterpenes cause hepatic and renal damage due to impairment on mitochondrial energy production, eliciting a collapse on adenosine triphosphate (ATP) synthesis and consequently impairment on bioenergetic homeostasis. Thus, the aim of this study was to evaluate w...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2018.09.009

    authors: Baldissera MD,Souza CF,De Matos AFIM,Baldisserotto B,da Silva AS,Monteiro SG

    更新日期:2018-12-25 00:00:00

  • Role of ELAV-like RNA-binding proteins HuD and HuR in the post-transcriptional regulation of acetylcholinesterase in neurons and skeletal muscle cells.

    abstract::Over the last few years, several laboratories have focused their attention on elucidating the molecular events that control the expression and localization of acetylcholinesterase (AChE) in neurons and skeletal muscle cells. In this context, results from a number of studies have clearly shown the important contributio...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2005.10.004

    authors: Deschênes-Furry J,Angus LM,Bélanger G,Mwanjewe J,Jasmin BJ

    更新日期:2005-12-15 00:00:00

  • Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.

    abstract::Pyridinium oximes are strong nucleophiles and many are effective reactivators of organophosphate-inhibited cholinesterase (ChE). However, the current oxime reactivators are ineffective at crossing the blood-brain barrier and reactivating brain ChE in the intact organism. Our laboratories have developed a series of sub...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2016.07.004

    authors: Chambers JE,Chambers HW,Funck KE,Meek EC,Pringle RB,Ross MK

    更新日期:2016-11-25 00:00:00

  • The effect of a minor constituent of essential oil from Citrus aurantium: the role of β-myrcene in preventing peptic ulcer disease.

    abstract::The monoterpene β-myrcene has been widely used in cosmetics, food and beverages, and it is normally found in essential oil from citrus fruit. The aim of this study was to investigate the anti-ulcer effects of β-myrcene on experimental models of ulcers that are induced by ethanol, NSAIDs (non-steroidal anti-inflammator...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2014.01.009

    authors: Bonamin F,Moraes TM,Dos Santos RC,Kushima H,Faria FM,Silva MA,Junior IV,Nogueira L,Bauab TM,Souza Brito AR,da Rocha LR,Hiruma-Lima CA

    更新日期:2014-04-05 00:00:00

  • Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine.

    abstract::It was aimed to identify the cytochrome(s) P450 (CYPs) involved in the N-demethylation and N-oxidation of clozapine (CLZ) by various approaches using human liver microsomes or microsomes from human B-lymphoblastoid cell lines. The maximum rates of formation were measured in the microsomal fraction of human livers and ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/s0009-2797(99)00006-x

    authors: Tugnait M,Hawes EM,McKay G,Eichelbaum M,Midha KK

    更新日期:1999-04-01 00:00:00

  • Effect of galangin supplementation on oxidative damage and inflammatory changes in fructose-fed rat liver.

    abstract::The study examined the effects of galangin (GA) on oxidative stress, inflammatory cytokine levels and nuclear factor-kappa B (NF-κB) activation in fructose-fed rat liver. Adult male albino Wistar rats were divided into 4 groups. Groups 1 and 4 received the control diet containing starch as the source of carbohydrate w...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2011.06.003

    authors: Sivakumar AS,Anuradha CV

    更新日期:2011-09-05 00:00:00

  • Targeting of acetylcholinesterase to lipid rafts of muscle.

    abstract::Despite the great progress made in setting the basis for the molecular diversity of acetylcholinesterase (AChE), an explanation for the existence of two types of amphiphilic subunits, with and without glicosylphosphatidylinositol (GPI) (Types I and II), has not been provided yet. In searching whether, as for the defic...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2008.04.018

    authors: Moral-Naranjo MT,Montenegro MF,Muñoz-Delgado E,Campoy FJ,Vidal CJ

    更新日期:2008-09-25 00:00:00

  • Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.

    abstract::Dietary flavonoid quercetin has been suggested as a cancer chemopreventive agent, but the mechanisms of action remain unclear. This study investigated the influence of quercetin on p38-MAPK and the potential regulation of the nuclear transcription factor erythroid-2p45-related factor (Nrf2) and the cellular antioxidan...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2011.12.005

    authors: Granado-Serrano AB,Martín MA,Bravo L,Goya L,Ramos S

    更新日期:2012-01-25 00:00:00

  • Mitochondrial DNA alterations in blood of the humans exposed to N,N-dimethylformamide.

    abstract::N,N-Dimethylformamide (DMF) has been widely used in industries because of its extensive miscibility with water and solvents. Its health effects include hepatotoxicity and male reproductoxicity, possibly linked with mitochondrial DNA (mtDNA) alterations including mtDNA common deletion (DeltamtDNA(4977)) and mtDNA copy ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2006.12.008

    authors: Shieh DB,Chen CC,Shih TS,Tai HM,Wei YH,Chang HY

    更新日期:2007-02-20 00:00:00