Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.

Abstract:

:Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear. Here, we show that naringin promotes fracture healing through stimulating angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.

journal_name

Chem Biol Interact

authors

Song N,Zhao Z,Ma X,Sun X,Ma J,Li F,Sun L,Lv J

doi

10.1016/j.cbi.2016.10.020

subject

Has Abstract

pub_date

2017-01-05 00:00:00

pages

11-17

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(16)30501-4

journal_volume

261

pub_type

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