Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors.

abstract：:Lanthanides (Ln) were known to induce cell apoptosis, which might be the results of their effects on mitochondria (MT). This study was trying to clarify the role of MT and reactive oxygen species (ROS) in Ln-induced apoptosis. We found that micromolar or lower concentration of La(3+), Gd(3+) and Yb(3+) bound to MT and...

journal_title：Chemico-biological interactions

authors： Liu H,Yuan L,Yang X,Wang K

更新日期：2003-07-25 00:00:00

abstract：:Polo-like kinase 1 (PLK1) is a prominent mediatory player during the cell cycle, mitosis, and cytokinesis in eukaryotic cells. Besides its physiological roles, PLK1 expression is upregulated in a wide range of human malignant tumors and its overexpression worsens prognosis, therefore, specific inhibition of PLK1 in tu...

journal_title：Chemico-biological interactions

authors： Ergul M,Bakar-Ates F

更新日期：2020-12-01 00:00:00

abstract：:Incubation of Ca2(+)-loaded rat liver mitochondria with N-acetyl-p-benzoquinone imine (NAPQI) or its two dimethylated analogues resulted in a concentration dependent Ca2+ release, with the following order of potency: 2,6-(Me)2-NAPQI greater than NAPQI greater than 3,5-(Me)2-NAPQI. The quinone imine-induced Ca2+ releas...

journal_title：Chemico-biological interactions

authors： Weis M,Moore GA,Cotgreave IA,Nelson SD,Moldeus P

更新日期：1990-01-01 00:00:00

abstract：:In the present study, the inhibition of human glutathione S-transferase P1-1 (GSTP1-1) by the flavonoid quercetin has been investigated. The results show a time- and concentration-dependent inhibition of GSTP1-1 by quercetin. GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h...

journal_title：Chemico-biological interactions

authors： van Zanden JJ,Ben Hamman O,van Iersel ML,Boeren S,Cnubben NH,Lo Bello M,Vervoort J,van Bladeren PJ,Rietjens IM

更新日期：2003-05-06 00:00:00

abstract：:Product yields have been determined after one-electron-induced reduction of CCl4 in aqueous solutions containing t-butanol and various concentrations of oxygen. It was shown that CCl3 radicals add oxygen to form CCl3O2 radicals, which eventually yield three chloride ions and CO2. A constant ratio of G(Cl-)/G(CO2) = 4 ...

journal_title：Chemico-biological interactions

authors： Mönig J,Bahnemann D,Asmus KD

更新日期：1983-10-15 00:00:00

abstract：:Chemopreventive potential of Acacia nilotica bark extract (ANBE) against single intraperitoneal injection of N-nitrosodiethylamine (NDEA, 200mg/kg) followed by weekly subcutaneous injections of carbon tetrachloride (CCl(4), 3 ml/kg) for 6 weeks induced hepatocellular carcinoma (HCC) in rats was studied. At 45 day afte...

journal_title：Chemico-biological interactions

authors： Singh BN,Singh BR,Sarma BK,Singh HB

更新日期：2009-09-14 00:00:00

abstract：:Over the last few decades, food allergy (FA) has become a common disease in infants in advanced countries. However, anti-allergic medicines available in the market have no effect on FA, and consequently effective drug therapies for FA are not yet available. We have already demonstrated that mucosal mast cells play an ...

journal_title：Chemico-biological interactions

authors： Wang X,Hayashi S,Umezaki M,Yamamoto T,Kageyama-Yahara N,Kondo T,Kadowaki M

更新日期：2014-12-05 00:00:00

abstract：:The goal of this research was to test the hypothesis that bioactivation reactions could be exploited to deliver and activate mitochondria-targeted antioxidant prodrugs. The concept that bioactivation reactions could be used for prodrug delivery and activation has received little attention. Most bioactivation reactions...

journal_title：Chemico-biological interactions

authors： Anders MW

更新日期：2011-06-30 00:00:00

abstract：:Fumonisin B1 induces cytotoxicity in sensitive cells by inhibiting ceramide synthase due to its structural similarity to the long-chain backbones of sphingolipids. The resulting accumulation of sphingoid bases has been established as a mechanism for fumonisin B1 cytotoxicity. We found that despite the accumulation of ...

journal_title：Chemico-biological interactions

authors： Sharma N,He Q,Sharma RP

更新日期：2004-12-30 00:00:00

abstract：:Plant-based systems continue to play an essential role in healthcare, and their use by different cultures has been extensively documented. Baccharis trimera, popularly known as carqueja, is a plant widely distributed in South America and has been traditionally used for treating several diseases particularly associated...

journal_title：Chemico-biological interactions

authors： Silveira Rabelo AC,Caldeira Costa D

更新日期：2018-12-25 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) elicit a spectrum of biochemical and toxic effects in exposed animals. In the present study, we assessed the effect of PCB structure, using four symmetrically-substituted PCBs, on cytochrome P450 (CYP)-mediated methoxy-, ethoxy- and benzyloxyresorufin O-dealkylase (MROD, EROD and BROD,...

journal_title：Chemico-biological interactions

authors： Edwards PR,Hrycay EG,Bandiera SM

更新日期：2007-08-15 00:00:00

abstract：:Drug induced liver injury (DILI), a major cause of pre- and post-approval failure, is challenging to predict pre-clinically due to varied underlying direct and indirect mechanisms. Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) and Ritonavir, a protease inhibitor, are antiviral drugs that cause c...

journal_title：Chemico-biological interactions

authors： Terelius Y,Figler RA,Marukian S,Collado MS,Lawson MJ,Mackey AJ,Manka D,Qualls CW Jr,Blackman BR,Wamhoff BR,Dash A

更新日期：2016-08-05 00:00:00

abstract：:The study examined the effects of galangin (GA) on oxidative stress, inflammatory cytokine levels and nuclear factor-kappa B (NF-κB) activation in fructose-fed rat liver. Adult male albino Wistar rats were divided into 4 groups. Groups 1 and 4 received the control diet containing starch as the source of carbohydrate w...

journal_title：Chemico-biological interactions

authors： Sivakumar AS,Anuradha CV

更新日期：2011-09-05 00:00:00

abstract：:Phenazines, naturally produced by bacteria and archaeal Methanosarcina species are nitrogen-containing tricyclic molecules with antibiotic, antitumoral, and antiparasitic activities. Phenazines are used as electron acceptors-donors in wide range of fields including environmental biosensors. In this study, the inhibito...

journal_title：Chemico-biological interactions

authors： Onder S,Biberoglu K,Tacal O

更新日期：2019-12-01 00:00:00

abstract：:Treatment of hepatic microsomes with Fe(3+)/ascorbate activates UDP-glucuronyltransferase (UGT), a phenomenon totally prevented and reversed by reducing agents. At microM concentrations, iron and copper ions catalyze the formation of ROS through Fenton and/or Haber-Weiss reactions. Unlike iron ions, indiscriminate bin...

journal_title：Chemico-biological interactions

authors： Letelier ME,Lagos F,Faúndez M,Miranda D,Montoya M,Aracena-Parks P,González-Lira V

更新日期：2007-04-05 00:00:00

abstract：:The cDNA for human liver phenol-sulfating phenol sulfotransferase (P-PST) has been cloned and the active enzyme expressed in Cos cells and bacteria. Analysis of the sequence identified two cysteine residues, one of which is highly conserved in the phenol sulfotransferase gene family. Previous studies with the pure hum...

journal_title：Chemico-biological interactions

authors： Falany CN,Zhuang W,Falany JL

更新日期：1994-06-01 00:00:00

abstract：:In terms of drug disposal and metabolism SDR21C1 (carbonyl reductase 1; CBR1) exerts an assorted substrate spectrum among a large variety of clinically relevant substances. Additionally, this short-chain dehydrogenase/reductase is extensively expressed in most tissues of the human body, thus underpinning its role in x...

journal_title：Chemico-biological interactions

authors： Seliger JM,Martin HJ,Maser E,Hintzpeter J

更新日期：2019-05-25 00:00:00

abstract：:The stability of small unilamellar vesicles formed by egg phosphatidylcholine has been examined in the presence of 38 tricyclic carboxamide DNA-intercalating agents (19 phenylquinolines, 17 phenylbenzimidazoles, an acridine and an anthracene). Lysis of the vesicular membrane is time-dependent and also dependent on the...

journal_title：Chemico-biological interactions

authors： O'Connor CJ,Emery DP,Tank H,Denny WA,Sunamoto J

更新日期：1990-01-01 00:00:00

abstract：:We investigated the chemopreventive effect of p-methoxycinnamic acid (p-MCA), an active phenolic acid of rice bran, turmeric, and Kaemperfia galanga against 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Male albino Wistar rats were randomly divided into six groups. Group 1 consisted of control rats that rece...

journal_title：Chemico-biological interactions

authors： Sivagami G,Karthikkumar V,Balasubramanian T,Nalini N

更新日期：2012-03-05 00:00:00

abstract：:The carcinogenic compound 2,4,6-trichlorophenol (2,4,6-TCP) was incubated with rat liver S-9 fraction. Three metabolites were identified: 2,6-dichloro-1,4-hydroquinone (DHQ), and two isomers of hydroxypentachlorodiphenyl ether (OH-Cl5-DPE). The latter are probably products of microsomal .OH radical attack on the trich...

journal_title：Chemico-biological interactions

authors： Juhl U,Blum K,Witte I

更新日期：1989-01-01 00:00:00

abstract：:Selenocysteine Se-conjugates (e.g. methylselenocysteine) have been shown to be potent chemopreventive and chemoprotective agents, and inducers of apoptosis. Although the mechanism of action remains to be elucidated, beta-elimination of these compounds by beta-lyase enzymes into corresponding selenols, pyruvate and amm...

journal_title：Chemico-biological interactions

authors： Rooseboom M,Vermeulen NP,Groot EJ,Commandeur JN

更新日期：2002-08-15 00:00:00

abstract：:Sophoricoside (SOPH) is an isoflavone glycoside isolated from the fruits of Sophora japonica. Since its first isolation in 1961, there are rare findings about the effects of SOPH on reproductive system. In the present study, the pregnant mice administrated by different doses of SOPH were used to explore the effect of ...

journal_title：Chemico-biological interactions

authors： Zhou J,Qu C,Sun Q,Wu L,Liu Y,Yang Z,Zhang J

更新日期：2014-08-05 00:00:00

abstract：:Depression is a common neuropsychiatric disorder whose pathophysiology has been associated with glutamatergic excitotoxicity. Thus, the research for new antidepressant strategies with the ability to mitigate glutamate toxicity has received growing attention. Given this background, the present study sought to investiga...

journal_title：Chemico-biological interactions

authors： Dalmagro AP,Camargo A,Severo Rodrigues AL,Zeni ALB

更新日期：2019-12-01 00:00:00

abstract：:Acetylcholinesterase (AChE) terminates cholinergic neurotransmission by hydrolyzing acetylcholine. The collagen-tailed AChE tetramer is a product of 2 genes, ACHE and ColQ. The AChE tetramer consists of 4 identical AChE subunits and one polyproline-rich peptide, whose function is to hold the 4 AChE subunits together. ...

journal_title：Chemico-biological interactions

authors： Toker L,Silman I,Zeev-Ben-Mordehai T,Sussman JL,Schopfer LM,Lockridge O

更新日期：2020-03-01 00:00:00

abstract：:Macrophages and inflammasome pathway are involved in high-glucose toxicity and development of insulin resistance. Silymarin (SMR) was known to modulate glucose homeostasis and reduce inflammation. However, it is still unknown whether SMR possess anti-hyperglycemic effects in diabetic-like knockout mice (Hnf-1αkin/-/In...

journal_title：Chemico-biological interactions

authors： Lu CP,Huang CY,Wang SH,Chiu CH,Li LH,Hua KF,Wu TH

更新日期：2018-06-25 00:00:00

abstract：:The non-covalent interactions of benzo[a]pyrene (BP) and several of its hydroxylated metabolites with ligandin, aminoazodye-binding protein A (Z-protein, fatty acid binding protein) and lecithin bilayers have been studied by equilibrium dialysis, an adsorption technique and fluorescence spectroscopy. Binding affinitie...

journal_title：Chemico-biological interactions

authors： Tipping E,Moore BP,Jones CA,Cohen GM,Ketterer B,Bridges JW

更新日期：1980-11-01 00:00:00

abstract：:The extent of DNA modification in cancerous rat live and lung tissues was investigated and compared to their respective normal tissues. Liver tumors were induced by 2-fluorenylacetamide (2-FAA) or N-nitroso-N-2-fluorenylacetamide (N-NO-2-FAA), and lung tumors were induced by sodium nitrite plus trimethylamine. In the ...

journal_title：Chemico-biological interactions

authors： Wang YJ,Ho YS,Lo MJ,Lin JK

更新日期：1995-02-01 00:00:00

abstract：:Melatonin and S-adenosyl-l-methionine (SAMe) prevent oxidative stress and tissue dysfunction in obstructive jaundice (OJ). Lipid peroxidation is exacerbated in the presence of trace amounts of iron (Fe). The study investigated the regulation by melatonin and SAMe the induction of oxidative stress, iron metabolism dist...

journal_title：Chemico-biological interactions

authors： Muñoz-Castañeda JR,Túnez I,Herencia C,Ranchal I,González R,Ramírez LM,Arjona A,Barcos M,Espejo I,Cruz A,Montilla P,Padillo FJ,Muntané J

更新日期：2008-07-30 00:00:00

abstract：:The mechanisms by which brassica vegetables might decrease the risk of cancer are reviewed in this paper. Brassicas, including all types of cabbages, broccoli, cauliflower and Brussels sprouts, may be protective against cancer due to their relatively high glucosinolate content. Glucosinolates are usually broken down t...

journal_title：Chemico-biological interactions

authors： Verhoeven DT,Verhagen H,Goldbohm RA,van den Brandt PA,van Poppel G

更新日期：1997-02-28 00:00:00

abstract：:Ribosomal protein S15A (RPS15A) has emerged as a novel oncogene of various human cancers. However, whether RPS15A is involved in pancreatic cancer remains unclear. In this study, we aimed to investigate the potential relevance of RPS15A in pancreatic cancer and elucidate the underlying regulatory mechanism. We found t...

journal_title：Chemico-biological interactions

authors： Liang J,Liu Y,Zhang L,Tan J,Li E,Li F

更新日期：2019-05-01 00:00:00