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Oroxylin A prevents alcohol-induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha.

Abstract：

:Accumulating data reveal that oroxylin A has beneficial effects against chronic liver disease. The previously studies showed oroxylin A, a flavonoid extracted from Scutellariae radix, improved acute liver injury and accelerated liver regeneration in vivo. However, it's unclear that the effect of oroxylin A on alcoholic liver disease. The present study was aimed at elucidating the effect of oroxylin A on alcohol-induced hepatic steatosis and the underlying mechanisms. Human hepatocyte LO2 were cultured and stimulated with ethanol for inducing LO2 damage. We examined the effects of oroxylin A on the accumulation of lipid droplets in ethanol-treated LO2. The results showed that oroxylin A reduced the accumulation of lipid droplets associated with regulating the lipid metabolism genes. Moreover, oroxylin A significantly suppressed the nuclear translocation of HIF-1α in ethanol-treated LO2. Furthermore, activation of HIF-1α significantly attenuated the effect of oroxylin A on lipid droplets accumulation and genes related to lipid metabolism in vitro and in vivo. Altogether, we demonstrated a HIF-1α-associated mechanism underlying oroxylin A inhibition of lipid deposition in ethanol-stimulated LO2. Oroxylin A modulation of HIF-1α level may represent a therapeutic remedy for ALD.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Jin H,Lian N,Bian M,Zhang C,Chen X,Shao J,Wu L,Chen A,Guo Q,Zhang F,Zheng S

doi

10.1016/j.cbi.2018.02.025

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

14-20

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(17)31105-5

journal_volume

285

pub_type

杂志文章

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