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Metabolic activation of benzo[a]pyrene in human skin maintained in short-term organ culture.

Abstract：

:The metabolic activation of benzo[a]pyrene (BP) was examined in six samples of human skin after topical application of the hydrocarbon to the skin in short-term organ culture. The results show that all of the samples were capable of metabolizing BP to water-soluble products and to ether-soluble products that included the 4,5-, 7,8- and 9,10-dihydrodiols and a product which had chromatographic properties identical with those of authentic trans-11,12-dihydro-11,12-dihydroxybenzo[a]pyrene (BP-11,12-diol). The major BP-deoxyribonucleoside adduct detected in each skin sample appeared to be formed from the reaction of r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BP-7,8-diol 9,10-oxide) with deoxyguanosine residues in DNA.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Weston A,Grover PL,Sims P

doi

10.1016/0009-2797(83)90082-0

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

359-71

issue

3

eissn

0009-2797

issn

1872-7786

pii

0009-2797(83)90082-0

journal_volume

45

pub_type

杂志文章

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