Abstract:
:Two homogenous fractions of hepatic metallothioneins ((Cd,Zn) MT-1 and (Cd,Zn) MT-2) and renal metal binding proteins ((Bi,Cu) BP-1 and (Bi,Cu) BP-2) were isolated from rats exposed to heavy metals and specific antisera to them were produced in rabbits. These antisera were tested by immunodiffusion and immunoelectrophoresis for their ability to bind different fractions of hepatic Cd,Zn-metallothionein and renal (Bi,Cu)-, (Hg,Cu)- and (Cd,Cu)-binding proteins. It was found that anti (Bi,Cu) BP antisera did not cross-react with hepatic (Cd,Zn) MT-1 and (Cd,Zn) MT-2. Strong immunological cross-reactions were detected between anti (Bi,Cu) BP antisera and individual forms of (Cd,Cu)-, (Hg,Cu)- and (Bi,Cu)-binding proteins isolated from rat kidneys.
journal_name
Chem Biol Interactjournal_title
Chemico-biological interactionsauthors
Zelazowski AJ,Szymańska JA,Cierniewski CSdoi
10.1016/0009-2797(80)90048-4subject
Has Abstractpub_date
1980-12-01 00:00:00pages
115-25issue
1eissn
0009-2797issn
1872-7786pii
0009-2797(80)90048-4journal_volume
33pub_type
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