当前位置： SCI文献检索 > CHEMICO-BIOLOGICAL INTERACTIONS期刊下所有文献 > Accumulation and elimination of macromolecular lesions in susceptible and non-susceptible rat tissues after repeated administration of trans-4-acetylaminostilbene.

Accumulation and elimination of macromolecular lesions in susceptible and non-susceptible rat tissues after repeated administration of trans-4-acetylaminostilbene.

Abstract：

:Trans-4-acetylaminostilbene (trans-AAS) is a potent carcinogen and quite specifically produces sebaceous gland tumors, predominantly in the Zymbal's gland of rats. It is also acutely toxic to the rat glandular stomach. Recent results have shown that these target tissues are not notably exposed to reactive metabolites after single administration of the compound. Therefore, experiments were designed to test whether multiple exposures cause changes in metabolic activation or repair of DNA-bound metabolites to the effect that target and non-target tissues accumulate macromolecular damage differently. Trans-[3H]AAS was orally administered to female Wistar rats in 12 doses over 6 weeks and binding of metabolites to proteins, RNA and DNA in several tissues as well as the pattern of adducts in liver nucleic acids were measured. In addition, the elimination of macromolecular-bound metabolites was determined at various intervals during the treatment. Metabolism and clearance of bound metabolites remained unaltered. As a consequence, DNA-bound metabolites accumulated in all tissues measured; to the greatest extent in the non-target tissues liver and kidney. Tissue exposure, as estimated by protein-binding, differed by a factor of 10 and decreased in the following order: liver, kidney, lung, Zymbal's gland, glandular stomach, mammary tissue. The results support the notion that neither the extent nor the persistence of DNA-binding correlate with the biological effects of trans-AAS.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Hilpert D,Neumann HG

doi

10.1016/s0009-2797(85)80154-x

subject

Has Abstract

pub_date

1985-06-01 00:00:00

pages

85-95

issue

1

eissn

0009-2797

issn

1872-7786

journal_volume

54

pub_type

杂志文章

相关文献

CHEMICO-BIOLOGICAL INTERACTIONS文献大全
  • Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase.

    abstract：:Butyrylcholinesterase (BChE) has proven to be an effective bioscavenger against nerve agents and organophosphates. Phase I safety trials of human BChE are currently being conducted and large-scale production of recombinant BChE is underway. Information on the real-time distribution of BChE from the injection site has ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2008.02.011

    authors： Duysen EG,Lockridge O

    更新日期：2008-09-25 00:00:00

  • Effects of organosulfurs, isothiocyanates and vitamin C towards hydrogen peroxide-induced oxidative DNA damage (strand breaks and oxidized purines/pyrimidines) in human hepatoma cells.

    abstract：:The aim of this study was to evaluate the effects of organosulfurs, isothiocyanates and vitamin C towards hydrogen peroxide-induced DNA damage (DNA strand breaks and oxidized purines/pyrimidines) in human hepatoma cells (HepG2), using the Comet assay. Treatment with hydrogen peroxide (H(2)O(2)) increased the levels of...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2007.05.006

    authors： Arranz N,Haza AI,García A,Delgado E,Rafter J,Morales P

    更新日期：2007-08-15 00:00:00

  • 4-Methylesculetin, a natural coumarin with intestinal anti-inflammatory activity, elicits a glutathione antioxidant response by different mechanisms.

    abstract：:4-methylesculetin (4 ME) is a natural antioxidant coumarin with protective effects on the intestinal inflammation, in which oxidative stress plays a key role in its aetiology and pathophysiology. Based on this, we examined the antioxidant molecular mechanisms involved in the intestinal anti-inflammatory activity of th...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2019.108876

    authors： Tanimoto A,Witaicenis A,Caruso ÍP,Piva HMR,Araujo GC,Moraes FR,Fossey MC,Cornélio ML,Souza FP,Di Stasi LC

    更新日期：2020-01-05 00:00:00

  • Effect of galangin supplementation on oxidative damage and inflammatory changes in fructose-fed rat liver.

    abstract：:The study examined the effects of galangin (GA) on oxidative stress, inflammatory cytokine levels and nuclear factor-kappa B (NF-κB) activation in fructose-fed rat liver. Adult male albino Wistar rats were divided into 4 groups. Groups 1 and 4 received the control diet containing starch as the source of carbohydrate w...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2011.06.003

    authors： Sivakumar AS,Anuradha CV

    更新日期：2011-09-05 00:00:00

  • The influence of p53 status on the cytotoxicity of fluorinated pyrimidine L-nucleosides.

    abstract：:Fluorinated nucleoside analogues are a major class of cancer chemotherapy agents, and include the drugs 5-fluorouracil (5FU) and 5-fluoro-2'-deoxyuridine (FdUrd). The aim of this study was to examine the cellular toxicity of two novel fluorinated pyrimidine L-nucleosides that are enantiomers of D-nucleosides and may b...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2015.08.010

    authors： Murray V,Taylor CB,Gero AM,Lutze-Mann LH

    更新日期：2015-10-05 00:00:00

  • Mitochondrial involvement in drug-induced hepatic injury.

    abstract：:Hepatic injury remains not only the commonest reason for the termination of drugs in their pre-clinical development but is also the most frequent reason for the withdrawal of approved drugs from the market. Mitochondria are the central point where the different signals responsible for initiating hepatocyte cell death ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbi.2006.06.007

    authors： Kass GE

    更新日期：2006-10-27 00:00:00

  • A novel fused 1,2,4-triazine aryl derivative as antioxidant and nonselective antagonist of adenosine A(2A) receptors in ethanol-activated liver stellate cells.

    abstract：:It has been detected that hepatic adenosine A(2A) receptors play an active role in the pathogenesis of hepatic fibrosis and suggest a novel therapeutic target in the treatment and prevention of hepatic cirrhosis. In this paper we examined if our new triazine derivative (IMT) can inhibit ethanol-induced activation of H...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2011.10.004

    authors： Szuster-Ciesielska A,Sztanke K,Kandefer-Szerszeń M

    更新日期：2012-01-05 00:00:00

  • Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.

    abstract：:The mechanisms by which soybean- and soybean isoflavone-enriched diets inhibit carcinogenesis are not known. We found that the isoflavones genistin and daidzin, and their respective aglucone forms daidzein and genistein, block 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin)-induced CYP1A1 enzyme activity. This inhi...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(99)00121-0

    authors： Shertzer HG,Puga A,Chang C,Smith P,Nebert DW,Setchell KD,Dalton TP

    更新日期：1999-11-15 00:00:00

  • Protective effects of diphenyl diselenide in a mouse model of brain toxicity.

    abstract：:Interest in organoselenide chemistry and biochemistry has increased in the past three decades, mainly due to their chemical and biological activities. Here, we investigated the protective effect of the organic selenium compound diphenyl diselenide (PhSe)2 (5 μmol/kg), in a mouse model of methylmercury (MeHg)-induced b...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2013.08.002

    authors： Glaser V,Moritz B,Schmitz A,Dafré AL,Nazari EM,Rauh Müller YM,Feksa L,Straliottoa MR,de Bem AF,Farina M,da Rocha JB,Latini A

    更新日期：2013-10-25 00:00:00

  • A subgroup of lactosyl-Sepharose binding proteins requires calcium for affinity and galactose for anti-proliferation.

    abstract：:Lactosyl-Sepharose binding proteins (LSBPs) were recently described in human pancreatic ductal adenocarcinoma (PDAC) Suit2-007 cells regarding their lectin-like properties and role in metastasis. This study further investigated how calcium and galactose influence the binding of LSBPs to the lactosyl resin as well as t...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.109354

    authors： Sagini MN,Hotz-Wagenblatt A,Berger MR

    更新日期：2021-01-25 00:00:00

  • Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1.

    abstract：:Rhizoma Chuanxiong is widely used as folk medicine to treat the diseases caused by oxidative stress and inflammation. To delineate the underlying molecular mechanisms, we recently found that Rhizoma Chuanxiong extract significantly induced heme oxygenase-1 (HO-1), an enzyme that degrades intracellular heme into three ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2009.11.029

    authors： Qi H,Siu SO,Chen Y,Han Y,Chu IK,Tong Y,Lau AS,Rong J

    更新日期：2010-02-12 00:00:00

  • Deprotonation and hydride shifts in nitrenium and iminium forms of aminoimidazole-azaarene mutagens.

    abstract：:The mutagenicity of many 2-aminoimidazole-azaarenes (AIA) is thought to be mediated by the nitrenium form of the exocyclic amine. This hypothesis is supported by the numerous correlations found between calculated and experimentally-measured chemical properties for the nitreniums and the mutagenic potencies of the nitr...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(97)00094-x

    authors： Colvin ME,Seidl ET,Nielsen IM,Le Bui L,Hatch FT

    更新日期：1997-12-12 00:00:00

  • Dosimetry of glycidyl ethers in mice by quantification of haemoglobin adducts.

    abstract：:Glycidyl ethers are used in epoxy resins. Epoxy resins are widely used in adhesives and coatings, as well as in electronics and structural composites, thus there is a potential of human exposure to glycidyl ethers. The aim of the present investigation was to explore the utility of haemoglobin adducts for biomonitoring...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(96)03744-1

    authors： Pérez HL,Plná K,Osterman-Golkar S

    更新日期：1997-01-24 00:00:00

  • Mechanisms underlying iron and copper ions toxicity in biological systems: Pro-oxidant activity and protein-binding effects.

    abstract：:Iron and copper ions, in their unbound form, may lead to the generation of reactive oxygen species via Haber-Weiss and/or Fenton reactions. In addition, it has been shown that copper ions can irreversibly and non-specifically bind to thiol groups in proteins. This non-specific binding property has not been fully addre...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2010.06.013

    authors： Letelier ME,Sánchez-Jofré S,Peredo-Silva L,Cortés-Troncoso J,Aracena-Parks P

    更新日期：2010-10-06 00:00:00

  • The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA.

    abstract：:The microsomal metabolism of pentachlorophenol (PCP) was investigated, with special attention to the conversion dependent covalent binding to protein and DNA. The two metabolites detected were tetrachloro-1,2- and tetrachloro-1,4-hydroquinone. Microsomes from isosafrole (ISF)-induced rats were by far the most effectiv...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(86)90013-x

    authors： van Ommen B,Adang A,Müller F,van Bladeren PJ

    更新日期：1986-10-15 00:00:00

  • Comparative excretion and tissue distribution of selenium in mice and rats following treatment with the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate.

    abstract：:In a previous preliminary investigation, we reported on the excretion, tissue disposition and metabolism of the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate (p-XSC) in the rat, but similar studies in the mouse have not been explored. Following the oral administration of p-XSC (50 micromol/kg body wei...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2004.10.007

    authors： Sohn OS,Desai DH,Das A,Rodriguez JG,Amin SG,El-Bayoumy K

    更新日期：2005-02-10 00:00:00

  • Artesunate induces autophagy dependent apoptosis through upregulating ROS and activating AMPK-mTOR-ULK1 axis in human bladder cancer cells.

    abstract：:Artesunate is a kind of derivative of artemisinin, which possesses potent anti-cancer effect in addition to its anti-malarial property. And autophagy was a highly conserved process, exerting a double-edged effect in cancer cell survival. Besides, apoptosis is a programmed cell death program, crucial to cell homeostasi...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.109273

    authors： Zhou X,Chen Y,Wang F,Wu H,Zhang Y,Liu J,Cai Y,Huang S,He N,Hu Z,Jin X

    更新日期：2020-11-01 00:00:00

  • Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles.

    abstract：:We report here the results of a collaborative research program to develop a robust and reliable in vitro system to allow an accurate definition of the drug-induced liver injury (DILI) potential of new drug entities during drug development. The in vitro hepatotoxic potential of 152 drugs with known DILI profiles were e...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2015.11.008

    authors： Zhang J,Doshi U,Suzuki A,Chang CW,Borlak J,Li AP,Tong W

    更新日期：2016-08-05 00:00:00

  • Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).

    abstract：:As part of our continuing search for bioactive natural products from plants, the present study was carried out in order to evaluate the gastroprotective properties of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora (Rutaceae). Anti-ulcer assays were performed using the following pro...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2009.04.001

    authors： Zanatta F,Gandolfi RB,Lemos M,Ticona JC,Gimenez A,Clasen BK,Cechinel Filho V,de Andrade SF

    更新日期：2009-07-15 00:00:00

  • Influence of toluene co-exposure on the metabolism and genotoxicity of benzene in mice using continuous and intermittent exposures.

    abstract：:Benzene exposure in occupational settings often occurs with concurrent exposure to toluene, the methyl-substituted derivative of benzene. Toluene is also readily metabolized by CYP450 isozymes although oxidation primarily occurs in the methyl group. While earlier mouse studies addressing co-exposure to benzene and tol...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2010.01.012

    authors： Bird MG,Wetmore BA,Letinski DJ,Nicolich M,Chen M,Schnatter AR,Whitman FT

    更新日期：2010-03-19 00:00:00

  • Cadmium induces the activation of cell wall integrity pathway in budding yeast.

    abstract：:MAP kinases are important signaling molecules regulating cell survival, proliferation and differentiation, and can be activated by cadmium stress. In this study, we demonstrate that cadmium induces phosphorylation of the yeast cell wall integrity (CWI) pathway_MAP kinase Slt2, and this cadmium-induced CWI activation i...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2015.09.007

    authors： Xiong B,Zhang L,Xu H,Yang Y,Jiang L

    更新日期：2015-10-05 00:00:00

  • In vivo metabolism of nasally instilled dihydrosafrole [1-(3,4-methylenedioxyphenyl)propane] in dogs and monkeys.

    abstract：:Nasal metabolism of inhaled material may influence its biological fate and toxicity. The purpose of this study was to investigate, in a noninvasive and qualitative manner, the in vivo nasal metabolic activity towards 1-(3,4-methylenedioxyphenyl)propane (dihydrosafrole). Dihydrosafrole was the compound of choice as a r...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(87)90056-1

    authors： Petridou-Fischer J,Whaley SL,Dahl AR

    更新日期：1987-01-01 00:00:00

  • Cancer risk assessment for 1,3-butadiene: dose-response modeling from an epidemiological perspective.

    abstract：:The dose-response assessment of the association between 1,3-butadiene (BD) and leukemia mortality among workers in the North American synthetic rubber industry is explored. Analyses are based on the most recent University of Alabama at Birmingham epidemiological study and exposure estimation. The U.S. EPA Science Advi...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2006.06.004

    authors： Sielken RL Jr,Valdez-Flores C,Gargas ML,Kirman CR,Teta MJ,Delzell E

    更新日期：2007-03-20 00:00:00

  • DL-2-Oxo-3-(2-mercaptoethyl)-5-phenylimidazolidine. A sulfhydryl metabolite of levamisole that interacts with microtubules.

    abstract：:DL-2-Oxo-3-(2-mercaptoethyl)-5-phenylimidazolidine (OMPI) a sulfhydryl metabolite of levamisole, unlike the parent compound, is shown to interfere with the morphological and functional integrity of microtubules in cultured cells at high concentrations (1.6-10(-4) M). Lower concentrations do not affect the cell morphol...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(78)90041-8

    authors： De Brabander M,Aerts F,Geuens G,van Ginckel R,van de Veire R,van Belle H

    更新日期：1978-10-01 00:00:00

  • Influence of quinidine on the intestinal secretion of digoxin and digitoxin in guinea pigs.

    abstract：:The secretion of digoxin and digitoxin into in situ perfused jejunal and colonic segments of normal or quinidine treated guinea pigs was studied. Quinidine was administered intravenously by constant rate infusion resulting in a quinidine plasma concentration of about 6 micrograms/ml. After 2 h digoxin or digitoxin was...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(85)80128-9

    authors： Schäfer SG,Schuhmann G,Doering W,Fichtl B

    更新日期：1985-10-01 00:00:00

  • S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis.

    abstract：:Endocrine therapies (e.g. tamoxifen and aromatase inhibitors) targeting estrogen action are effective in decreasing mortality of breast cancer. However, their efficacy is limited by intrinsic and acquired resistance. Our previous study demonstrated that overexpression of a histone methyltransferase NSD2 drives tamoxif...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.108965

    authors： Wang Q,Zheng J,Zou JX,Xu J,Han F,Xiang S,Liu P,Chen HW,Wang J

    更新日期：2020-02-01 00:00:00

  • Role of intracellular reactive oxygen species and mitochondrial dysfunction in evening primrose extract-induced apoptosis in Ehrlich ascites tumor cells.

    abstract：:Herbal medicines are increasingly being utilized to treat a wide variety of disease processes. Evening primrose extract (EPE) is extracted from Oenothera biennis L., one species of evening primroses, which has been shown to have several pharmacological effects. However, anti-tumor activity in the extract of defatted s...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(03)00060-7

    authors： Arimura T,Kojima-Yuasa A,Watanabe S,Suzuki M,Kennedy DO,Matsui-Yuasa I

    更新日期：2003-06-15 00:00:00

  • Regulation of aldose reductase and the polyol pathway activity by nitric oxide.

    abstract：:Increased flux of glucose through the polyol pathway has been implicated in the pathophysiology of secondary diabetic complications. The first step of this pathway, which generates sorbitol from glucose, is catalyzed by aldose reductase (AR) (AKR1B). In vitro, the binding of substrates and inhibitors to AR is highly s...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(02)00214-4

    authors： Srivastava SK,Ramana KV,Chandra D,Srivastava S,Bhatnagar A

    更新日期：2003-02-01 00:00:00

  • Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine.

    abstract：:The inhibitory effects of antihypertensive drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors) on cytochrome P450 2J2 (CYP2J2) activity were examined. Amlodipine, azelnidipine, barnidipine, benidipine, cilnidipine, efonidipine, felodipine, ma...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2019.04.005

    authors： Ikemura N,Yamaori S,Kobayashi C,Kamijo S,Murayama N,Yamazaki H,Ohmori S

    更新日期：2019-06-01 00:00:00

  • Interactions of safrole and isosafrole and their metabolites with cytochromes P-450.

    abstract：:The structural features which determine interaction of safrole and related methylenedioxyphenyl compounds with cytochromes P-450 or P-448, and determine the induction of these two classes of the cytochrome, have been studied. All methylenedioxyphenyl compounds studied interact with both cytochromes P-450 and P-448 eli...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(85)80106-x

    authors： Ioannides C,Delaforge M,Parke DV

    更新日期：1985-05-01 00:00:00