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Thioredoxin redox control of cell growth and death and the effects of inhibitors.

Abstract：

:Thioredoxin is a redox protein found over-expressed in some human tumors. Thioredoxin is secreted by tumor cells and stimulates cancer cell growth. Redox activity is essential for growth stimulation by thioredoxin. Cells transfected with thioredoxin cDNA show increased tumor growth and decreased apoptosis in vivo and decreased sensitivity to apoptosis induced by a variety of agents both in vitro and in vivo. Cells transfected with a redox-inactive mutant thioredoxin show inhibited tumor growth in vivo. Thus, thioredoxin offers an attractive target for anticancer drug development. A class of disulfide inhibitors of thioredoxin has been identified. These disulfides inhibit cancer cell growth in culture and have antitumor activity against some human tumor xenografts in animals.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Powis G,Kirkpatrick DL,Angulo M,Baker A

doi

10.1016/s0009-2797(97)00148-8

subject

Has Abstract

pub_date

1998-04-24 00:00:00

pages

23-34

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(97)00148-8

journal_volume

111-112

pub_type

杂志文章,评审

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