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Effect of DNA synthesis on induction of preneoplastic and neoplastic lesions in rat liver by a single dose of methylazoxymethanol acetate.

Abstract：

:A single intravenous injection of methylazoxymethanol (MAM) acetate in doses of either 20 or 35 mg/kg body weight to male Sprague-Dawley rats induced altered liver cell foci and later, liver neoplasms in a dose related manner. Sequential observations in the rats given 35 mg/kg and thereafter fed an iron-loading diet revealed that the number of iron-excluding foci/cm2 increased with time. Partial hepatectomy (PH) before the high dose of MAM acetate resulted in 100% lethality while hepatectomy before the low dose carcinogen exposure lead to a higher incidence of neoplasms than in rats that received carcinogen alone. PH after either high or low dose carcinogen exposure did not result in a greater occurrence of liver neoplasms.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Tanaka T,Mori H,Hirota N,Furuya K,Williams GM

doi

10.1016/s0009-2797(86)80083-7

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

13-27

issue

1

eissn

0009-2797

issn

1872-7786

journal_volume

58

pub_type

杂志文章

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