当前位置： SCI文献检索 > CHEMICO-BIOLOGICAL INTERACTIONS期刊下所有文献 > Effects of a novel microtubule-depolymerizer on pro-inflammatory signaling in RAW264.7 macrophages.

Effects of a novel microtubule-depolymerizer on pro-inflammatory signaling in RAW264.7 macrophages.

Abstract：

:The Nuclear Factor-kappa B (NF-κB) pathway is vital for immune system regulation and pro-inflammatory signaling. Many inflammatory disorders and diseases, including cancer, are linked to dysregulation of NF-κB signaling. When macrophages recognize the presence of a pathogen, the signaling pathway is activated, resulting in the nuclear translocation of the transcription factor, NF-κB, to turn on pro-inflammatory genes. Here, we demonstrate the effects of a novel microtubule depolymerizer, NT-07-16, a polysubstituted pyrrole compound, on this process. Treatment with NT-07-16 decreased the production of pro-inflammatory cytokines in RAW264.7 mouse macrophages. It appears that the reduction in pro-inflammatory mediators produced by the macrophages after exposure to NT-07-16 may be due to activities upstream of the translocation of NF-κB into the nucleus. NF-κB translocation occurs after its inhibitory protein, IκB-α is phosphorylated which signals for its degradation releasing NF-κB so it is free to move into the nucleus. Previous studies from other laboratories indicate that these processes are associated with the microtubule network. Our results show that exposure to the microtubule-depolymerizer, NT-07-16 reduces the phosphorylation of IκB-α and also decreases the association of NF-κB with tubulin which may affect the ability of NF-κB to translocate into the nucleus. Therefore, the anti-inflammatory activity of NT-07-16 may be explained, at least in part, by alterations in these steps in the NF-κB signaling pathway leading to less NF-κB entering the nucleus and reducing the production of pro-inflammatory mediators by the activated macrophages.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Gilmore SP,Gonye ALK,Li EC,Espinosa de Los Reyes S,Gupton JT,Quintero OA,Fischer-Stenger K

doi

10.1016/j.cbi.2017.12.019

subject

Has Abstract

pub_date

2018-01-25 00:00:00

pages

109-116

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(17)31084-0

journal_volume

280

pub_type

杂志文章

相关文献

CHEMICO-BIOLOGICAL INTERACTIONS文献大全
  • Comparison of long-term versus short-term effects of okadaic acid on the apoptotic status of human HepaRG cells.

    abstract：:The biotoxin okadaic acid (OA) is a lipophilic secondary metabolite of marine microalgae. Therefore, OA accumulates in the fatty tissue of various shellfish and may thus enter the food chain. The ingestion of OA via contaminated marine species can lead to the diarrhetic shellfish poisoning syndrome characterized by th...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.108937

    authors： Dietrich J,Schindler M,Lampen A,Braeuning A,Hessel-Pras S

    更新日期：2020-02-01 00:00:00

  • Lon protease and eiF2α are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells.

    abstract：:Lon protease, an ATP dependent mitochondrial protease, is important in mitochondrial protein maintenance. Disruption of protein homeostasis and mitochondrial dysfunction is associated with lipodystrophy, metabolic syndrome and accelerated aging, and are commonly observed in patients on long term antiretroviral therapy...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2016.03.021

    authors： Nagiah S,Phulukdaree A,Chuturgoon AA

    更新日期：2016-05-25 00:00:00

  • Potent inhibition of human carbonyl reductase 1 (CBR1) by the prenylated chalconoid xanthohumol and its related prenylflavonoids isoxanthohumol and 8-prenylnaringenin.

    abstract：:In terms of drug disposal and metabolism SDR21C1 (carbonyl reductase 1; CBR1) exerts an assorted substrate spectrum among a large variety of clinically relevant substances. Additionally, this short-chain dehydrogenase/reductase is extensively expressed in most tissues of the human body, thus underpinning its role in x...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2019.02.031

    authors： Seliger JM,Martin HJ,Maser E,Hintzpeter J

    更新日期：2019-05-25 00:00:00

  • Mechanism of action and fate of the fungicide chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) in biological systems. 2. In vitro reactions.

    abstract：:The reaction characteristics of chlorothalonil with glyceraldehyde-3-phosphate dehydrogenase (GPDH), from yeast, (EC 1.2.1.12) were studied in vitro. Enzyme inhibition was related to the amount of [14C]chlorothalonil bound to the protein. Kinetics of enzyme inhibition was non-competitive for the substrate glyceraldehy...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(75)90069-1

    authors： Long JW,Siegel MR

    更新日期：1975-06-01 00:00:00

  • In vitro cytotoxicity of montelukast in HAPI and SH-SY5Y cells.

    abstract：:Montelukast is a cysteinyl leukotriene (CysLT) receptor antagonist with efficacy against a variety of diseases, including asthma and inflammation-related conditions. However, various neuropsychiatric events (NEs) suspected to be related to montelukast have been reported recently, with limited understanding on their as...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.109134

    authors： Tseng YT,Cox TM,Grant GD,Arora D,Hall S,McFarland AJ,Ekberg J,Rudrawar S,Anoopkumar-Dukie S

    更新日期：2020-08-01 00:00:00

  • Characterization of reaction products between styrene oxide and deoxynucleosides and DNA.

    abstract：:Styrene oxide was reacted with deoxynucleosides and DNA in aqueous buffer at pH 7.4. The products were purified by HPLC, characterized by UV spectroscopy and by chemical ionization mass spectrometry. The main products identified were 7-alkyl-, N2-alkyl- and O6-alkyldeoxyguanosine, 1-alkyl-, and N6-alkyldeoxyadenosine,...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(86)90055-4

    authors： Savela K,Hesso A,Hemminki K

    更新日期：1986-12-01 00:00:00

  • Oxidative stress, DNA damage and apoptosis induced by tebuconazole in the kidney of male Wistar rat.

    abstract：:Tebuconazole (TEB) is a broad-spectrum conazole fungicide that has been used in agriculture in the control of foliar and soil-borne diseases of many crops. The present study has investigated the adverse effects of subchronic exposure to TEB on the kidney of male rats. Animals were divided into four equal groups and tr...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.109114

    authors： Othmène YB,Hamdi H,Salem IB,Annabi E,Amara I,Neffati F,Najjar MF,Abid-Essefi S

    更新日期：2020-10-01 00:00:00

  • La(3+), Gd(3+) and Yb(3+) induced changes in mitochondrial structure, membrane permeability, cytochrome c release and intracellular ROS level.

    abstract：:Lanthanides (Ln) were known to induce cell apoptosis, which might be the results of their effects on mitochondria (MT). This study was trying to clarify the role of MT and reactive oxygen species (ROS) in Ln-induced apoptosis. We found that micromolar or lower concentration of La(3+), Gd(3+) and Yb(3+) bound to MT and...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(03)00072-3

    authors： Liu H,Yuan L,Yang X,Wang K

    更新日期：2003-07-25 00:00:00

  • Chromatographic resolution of amino acid adducts of aliphatic halides.

    abstract：:Numerous xenobiotics are known to be bioactivated and to covalently and to proteins, but the resulting amino acid adducts (AAAs) are unknown. In this study the AAAs of twelve 14C-labeled aliphatic halides were examined after formation in an in vitro microsomal system. After exhaustive solvent extraction of the precipi...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(82)90038-2

    authors： Maiorino RM,Gandolfi AJ,Brendel K,Mac Donald JR,Sipes IG

    更新日期：1982-01-01 00:00:00

  • A spectrophotometric assay of gamma-glutamylcysteine synthetase and glutathione synthetase in crude extracts from tissues and cultured mammalian cells.

    abstract：:An assay of gamma-glutamylcysteine synthetase (gamma-GCS) and glutathione synthetase (GS) in crude extracts of cultured cells and tissues is described. It represents a novel combination of known methods, and is based on the formation of glutathione (GSH) from cysteine, glutamate and glycine in the presence of rat kidn...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(02)00017-0

    authors： Volohonsky G,Tuby CN,Porat N,Wellman-Rousseau M,Visvikis A,Leroy P,Rashi S,Steinberg P,Stark AA

    更新日期：2002-04-20 00:00:00

  • Association of variants of the -116 site of the butyrylcholinesterase BCHE gene to enzyme activity and body mass index.

    abstract：:Butyrylcholinesterase (BChE) is coded by the BCHE gene that presents four exons. The non-codifying exon 1 presents two variants -116G and -116A, being -116A preferentially in cis conformation with the 539T variant (K) of exon 4 which was associated with lower BChE activity and lower body mass index (BMI) variance. Thi...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2008.04.019

    authors： Furtado-Alle L,Andrade FA,Nunes K,Mikami LR,Souza RL,Chautard-Freire-Maia EA

    更新日期：2008-09-25 00:00:00

  • The lysosomal-mitochondrial axis theory of postmitotic aging and cell death.

    abstract：:Aging (senescence) is characterized by a progressive accumulation of macromolecular damage, supposedly due to a continuous minor oxidative stress associated with mitochondrial respiration. Aging mainly affects long-lived postmitotic cells, such as neurons and cardiac myocytes, which neither divide and dilute damaged s...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章,评审

    doi：10.1016/j.cbi.2006.04.013

    authors： Terman A,Gustafsson B,Brunk UT

    更新日期：2006-10-27 00:00:00

  • Analysis and characterization of eight estradiol inducible genes and a strong promoter from the steroid degrading marine bacterial strain S19-1.

    abstract：:Buttiauxella strain S19-1 is a new marine bacterium, isolated from the Baltic Sea, which can degrade steroids. In this report, a meta-genomic approach was used to isolate estradiol inducible genes from S19-1. SalI-fragments from the chromosomal DNA of S19-1 were ligated into plasmid pKEGFP2 bearing an EGFP gene as the...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2012.11.018

    authors： Zhang T,Xiong G,Maser E

    更新日期：2013-02-25 00:00:00

  • The impact of skin decontamination on the time window for effective treatment of percutaneous VX exposure.

    abstract：:The main goal of the present study was to obtain insight into depot formation and penetration following percutaneous VX poisoning, in order to identify an appropriate decontamination window that can enhance or support medical countermeasures. The study was executed in two phases, using the hairless guinea pig as an an...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2016.02.001

    authors： Joosen MJ,van den Berg RM,de Jong AL,van der Schans MJ,Noort D,Langenberg JP

    更新日期：2017-04-01 00:00:00

  • A review of the epidemiology of 1,3-butadiene and chloroprene.

    abstract：:Butadiene epidemiologic research has focused primarily on one cohort of workers in the North American styrene-butadiene rubber (SBR) industry and on the largest cohort of workers in the United States butadiene monomer industry. The most recent studies of these populations are characterized by carefully enumerated stud...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章,评审

    doi：10.1016/s0009-2797(01)00169-7

    authors： Acquavella JF,Leonard RC

    更新日期：2001-06-01 00:00:00

  • Benzene-induced bone-marrow toxicity: a hematopoietic stem-cell-specific, aryl hydrocarbon receptor-mediated adverse effect.

    abstract：:Benzene-induced hematopoietic toxicity is an aryl hydrocarbon receptor (AhR)-related adverse effect that is not exhibited in AhR-knockout (KO) mice. In the hematopoietic system, the steady-state expression of AhRs is limited in the hematopoietic progenitor cells; thus, a hierarchical hematopoietic impairment starts fr...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2009.12.022

    authors： Hirabayashi Y,Inoue T

    更新日期：2010-03-19 00:00:00

  • On the reaction kinetics in water of 1,3-propane sultone and 1,4-butane sultone: a comparison of reaction rates and mutagenic activities of some alkylating agents.

    abstract：:To determine correlations between the biological action pattern and chemical reactivity of alkylating agents, the rate constants for reactions of 1,3-propane sultone and 1,4-butane sultone with a series of nucleophiles at 37 degrees C have been determined. Previously published data on the mutagenicity of the two sulto...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(76)90036-3

    authors： Osterman-Golkar S,Wachtmeister CA

    更新日期：1976-07-01 00:00:00

  • A peptide derived from acetylcholinesterase is a pivotal signalling molecule in neurodegeneration.

    abstract：:It is now widely accepted that acetylcholinesterase (AChE) also displays non-cholinergic functions, completely independent of cholinergic transmission. Indeed, AChE has been implicated in a variety of trophic and toxic actions in a range of different systems. However, it is still uncertain what part of the AChE molecu...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2005.10.032

    authors： Greenfield S

    更新日期：2005-12-15 00:00:00

  • The diversity of microbial aldo/keto reductases from Escherichia coli K12.

    abstract：:The genome of Escherichia coli K12 contains 9 open reading frames encoding aldo/keto reductases (AKRs) that are differentially regulated and sequence diverse. A significant amount of data is available for the E. coli AKRs through the availability of gene knockouts and gene expression studies, which adds to the biochem...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2012.10.008

    authors： Lapthorn AJ,Zhu X,Ellis EM

    更新日期：2013-02-25 00:00:00

  • Mechanistic evaluation of gastroprotective effects of Kangfuxin on ethanol-induced gastric ulcer in mice.

    abstract：:This study was designed to evaluate the gastroprotective effect of Kangfuxin (KFX), a Chinese patent medicine constituent isolated from American cockroach, on ethanol-induced gastric ulcer in mice and to elucidate the potential mechanisms of the effect involved. According to the results, mice treated with alcohol appe...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2017.06.007

    authors： Shen Y,Sun J,Niu C,Yu D,Chen Z,Cong W,Geng F

    更新日期：2017-08-01 00:00:00

  • Inhibitory effect of hemin on mutagenicity of the electrophilic sulfuric acid ester of 6-hydroxymethylbenzo[a]pyrene.

    abstract：:In the present study, we examined the effects of hemin on the mutagenicity of 6-sulfooxymethylbenzo[a]pyrene (SMBP) in Salmonella typhimurium TA98 and Chinese hamster lung fibroblast (V79) cells. The compound was tested for the possible chemoprotective activity against mutagenesis induced by SMBP and its precursor, 6-...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(97)00137-3

    authors： Hong ST,Cho YS,Surh YJ,Chung AS

    更新日期：1998-02-20 00:00:00

  • The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA.

    abstract：:The microsomal metabolism of pentachlorophenol (PCP) was investigated, with special attention to the conversion dependent covalent binding to protein and DNA. The two metabolites detected were tetrachloro-1,2- and tetrachloro-1,4-hydroquinone. Microsomes from isosafrole (ISF)-induced rats were by far the most effectiv...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(86)90013-x

    authors： van Ommen B,Adang A,Müller F,van Bladeren PJ

    更新日期：1986-10-15 00:00:00

  • Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers.

    abstract：:Fluorogenic organophosphate inhibitors of acetylcholinesterase (AChE) homologous in structure to nerve agents provide useful probes for high throughput screening of mammalian paraoxonase (PON1) libraries generated by directed evolution of an engineered PON1 variant with wild-type like specificity (rePON1). Wt PON1 and...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2010.02.039

    authors： Ashani Y,Gupta RD,Goldsmith M,Silman I,Sussman JL,Tawfik DS,Leader H

    更新日期：2010-09-06 00:00:00

  • A subgroup of lactosyl-Sepharose binding proteins requires calcium for affinity and galactose for anti-proliferation.

    abstract：:Lactosyl-Sepharose binding proteins (LSBPs) were recently described in human pancreatic ductal adenocarcinoma (PDAC) Suit2-007 cells regarding their lectin-like properties and role in metastasis. This study further investigated how calcium and galactose influence the binding of LSBPs to the lactosyl resin as well as t...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.109354

    authors： Sagini MN,Hotz-Wagenblatt A,Berger MR

    更新日期：2021-01-25 00:00:00

  • Cyclic nucleotides levels in the liver of rats treated with CCl4.

    abstract：:Treatment of rats with two different doses of CCl4 (respectively 2.5 and 0.5 ml/kg body wt. intragastrically) is followed by a rapid increase in the cAMP content of the liver. With 0.5 ml of CCl4, the increase occurs as early as 30 min after poisoning, namely about 4-5 h before the onset of triglyceride accumulation i...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(79)90089-9

    authors： Paradisi L,Dianzani MU

    更新日期：1979-06-01 00:00:00

  • Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status.

    abstract：:Copper is an essential trace metal for physiological functions, whereas copper overload causes cytotoxicity in living organisms. Genetically determined systems regulate acquisition, distribution and storage for copper maintenance and homeostasis. The Human ATP7A copper transport ATPase modulates intracellular copper d...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2010.12.003

    authors： Chen HR,Yang HC,Hsieh DJ,Liu Z,Tsai KJ

    更新日期：2011-02-01 00:00:00

  • Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes.

    abstract：:Dioxinodehydroeckol (DHE) isolated from Ecklonia cava, has previously been investigated for its inhibition of the differentiation of 3T3-L1 preadipocytes into adipocytes. Levels of lipid accumulation were measured, along with changes in the expression of genes and proteins associated with adipogenesis and lipolysis. C...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2010.04.003

    authors： Kim SK,Kong CS

    更新日期：2010-06-07 00:00:00

  • Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells.

    abstract：:The effects of three fatty acids on cytotoxic aggregate formation of Ca(2+)-depleted bovine alpha-lactalbumin (apo-BLA) have been studied by UV absorbance spectroscopy and transmission electron microscopy. The experimental results demonstrate that two unsaturated fatty acids, oleic acid and linoleic acid, and one satu...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2009.03.019

    authors： Zhang M,Yang F Jr,Yang F,Chen J,Zheng CY,Liang Y

    更新日期：2009-07-15 00:00:00

  • Cromolyn chitosan nanoparticles as a novel protective approach for colorectal cancer.

    abstract：:Colorectal cancer is the third most common cancer in the world. Cromolyn is a mast cell stabilizer and was proposed as an anticancer agent; however its high polarity limits its bioavailability by rapid washing from the body. We formulated 10 cromolyn chitosan nanoparticles (CCSNPs)1 following ionic gelation technique ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2017.07.013

    authors： Motawi TK,El-Maraghy SA,ElMeshad AN,Nady OM,Hammam OA

    更新日期：2017-09-25 00:00:00

  • Radiosensitizing properties of novel hydroxydicarboxylatoplatinum(II) complexes with high or low reactivity with thiols: two modes of action.

    abstract：:We examined radiosensitizing properties of two novel platinum complexes (ethylenediamine(L-malato)platinum(II)), Pt1 and bis(1-ethylimidazole(L-malato)platinum(II)), Pt4. Initial double strand break (DSB) level and DSB rejoining were measured, using pulse field gel electrophoresis (PFGE) in human G1 phase lymphocytes ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(03)00106-6

    authors： Gradzka I,Buraczewska I,Kuduk-Jaworska J,Romaniewska A,Szumiel I

    更新日期：2003-10-25 00:00:00