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On the reaction kinetics in water of 1,3-propane sultone and 1,4-butane sultone: a comparison of reaction rates and mutagenic activities of some alkylating agents.

Abstract：

:To determine correlations between the biological action pattern and chemical reactivity of alkylating agents, the rate constants for reactions of 1,3-propane sultone and 1,4-butane sultone with a series of nucleophiles at 37 degrees C have been determined. Previously published data on the mutagenicity of the two sultones and of some alkyl methanesulfonates and dialkyl sulfates towards Schizosaccharomyces pombe have been used in the evaluation of the dependence of mutagenic effectiveness on chemical reactivity. It is of interest to note that the mutagenic effectiveness of the two sultones, if expressed per alkylating event at a certain low nucleophilicity is the same as that of e.g. methyl methanesulfonate and ethyl methanesulfonate.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Osterman-Golkar S,Wachtmeister CA

doi

10.1016/0009-2797(76)90036-3

subject

Has Abstract

pub_date

1976-07-01 00:00:00

pages

195-202

issue

1-2

eissn

0009-2797

issn

1872-7786

pii

0009-2797(76)90036-3

journal_volume

14

pub_type

杂志文章

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