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Muscular dystrophy with laminin deficiency decreases acetylcholinesterase activity in thymus of dystrophic Lama2dy mice.

Abstract：

:We have studied the effect of muscular dystrophy by merosin deficiency on mouse thymus acetyl- (AChE) and butyrylcholinesterase (BuChE). The organ contains AChE and BuChE activities. Merosin deficiency causes an important decrease (46%) in AChE specific activity. Thymus produces dimers, monomers and tetramers of AChE, and the three kinds of AChE mRNAs. The drop in AChE activity in dystrophic animals could affect the amount of ACh reaching cholinergic receptors in cells of lymphoid organs.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Sánchez del Campo L,Nieto-Cerón S,Muñoz-Delgado E,Vidal CJ,Campoy FJ

doi

10.1016/j.cbi.2005.10.092

subject

Has Abstract

pub_date

2005-12-15 00:00:00

pages

431-2

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(05)00333-9

journal_volume

157-158

pub_type

杂志文章

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