Tetraalkylammonium ions: protection of murine L1210 leukemia and bone marrow progenitor cells in vitro against mechlorethamine cytotoxicity and inhibition of the choline transport system.

abstract：:Ultraviolet absorption data and thermal chromatography through hydroxyapatite (HAP) column revealed that furazolidone treatment of Vibrio cholerae cells produced more than 80% of DNA reversibly bihelical due to the formation of interstrand cross-links and the reaction obeyed a first order relation. Sensitivities of th...

journal_title：Chemico-biological interactions

authors： Chatterjee SN,Banerjee SK,Pal AK,Basak J

更新日期：1983-08-01 00:00:00

abstract：:DNA damage and DNA repair have been observed in cultured human skin fibroblasts exposed to potassium chromate but not to a chromic glycine complex. DNA repair synthesis (unscheduled incorporation of [3H]thymidine (TdR)) was measured in cells during or following exposure to chromate and was significant for chromate con...

journal_title：Chemico-biological interactions

authors： Whiting RF,Stich HF,Koropatnick DJ

更新日期：1979-08-01 00:00:00

abstract：:The interaction of the potent tumor-promoting agent phorbol myristate acetate (PMA) with purified rat liver plasma membranes suspended in phosphate-buffered saline (PBS), pH 7.4, was studied by fluorescence spectrophotometry. Exposure of membranes to PMA caused up to 21% decrease of the native membrane emission, i.e. ...

journal_title：Chemico-biological interactions

authors： van Duuren BL,Banerjee S,Witz G

更新日期：1976-11-01 00:00:00

abstract：:Nicotine exposure increases the release of glutamate in part through stimulatory effects on pre-synaptic nicotinic acetylcholine receptors (nAChRs). To assess the impact of chronic electronic (e)-cigarette use on these drug dependence pathways, we exposed C57BL/6 mice to three types of inhalant exposures for 3 months;...

journal_title：Chemico-biological interactions

authors： Alasmari F,Crotty Alexander LE,Hammad AM,Horton A,Alhaddad H,Schiefer IT,Shin J,Moshensky A,Sari Y

更新日期：2021-01-05 00:00:00

abstract：:Mitochondrial dysfunction appears to contribute to some of the loss of function accompanying ageing. Mitochondria from aged tissue use oxygen inefficiently impairing ATP synthesis and results in increased oxidant production. A high flux of oxidants not only damages mitochondria, but other important cell biomolecules a...

journal_title：Chemico-biological interactions

authors： Arivazhagan P,Ramanathan K,Panneerselvam C

更新日期：2001-11-28 00:00:00

abstract：:Dietary flavonoid quercetin has been suggested as a cancer chemopreventive agent, but the mechanisms of action remain unclear. This study investigated the influence of quercetin on p38-MAPK and the potential regulation of the nuclear transcription factor erythroid-2p45-related factor (Nrf2) and the cellular antioxidan...

journal_title：Chemico-biological interactions

authors： Granado-Serrano AB,Martín MA,Bravo L,Goya L,Ramos S

更新日期：2012-01-25 00:00:00

abstract：:Male CBA mice were exposed to propene, unlabelled or 14C-labelled, by inhalation, or to 14C-labelled propylene oxide by intraperitoneal injection. 2-Hydroxypropyl adducts to guanine-N-7 in DNA of various organs and to N-terminal valine and histidine-N pi in hemoglobin were measured. The adduct levels observed show tha...

journal_title：Chemico-biological interactions

authors： Svensson K,Olofsson K,Osterman-Golkar S

更新日期：1991-01-01 00:00:00

abstract：:5-Iodouracil (IUra)-substituted progeny bacteriophage T4td8 were grown under conditions such that, upon CsCl equilibrium isopycnic gradient centrifugation, progeny with density distributions about the median similar to that of unsubstituted phage are obtained. In the absence of light a monotonic relationship exists be...

journal_title：Chemico-biological interactions

authors： Byrd DM,Prusoff WH

更新日期：1976-02-01 00:00:00

abstract：:V-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) is a member of CRK family and act as an adaptor protein participating in intra-cellular signal transduction. The role of CRKL in gastric cancer (GC) remains unclear. In this study, we show that CRKL was aberrantly highly expressed in both GC tumor specimens a...

journal_title：Chemico-biological interactions

authors： Wang J,Chen X,Li P,Su L,Yu B,Cai Q,Li J,Yu Y,Liu B,Zhu Z

更新日期：2013-11-25 00:00:00

abstract：:UDP-glucuronosyltransferases (UGTs) are a family of phase II drug metabolizing enzymes that catalyze glucuronidation of numerous endogenous and exogenous substrates. Carbon tetrachloride (CCl4) is widely used to develop liver injuries mimicking human liver diseases. However, effects of CCl4 on the expression and activ...

journal_title：Chemico-biological interactions

authors： Xu L,Zheng R,Xie P,Guo Q,Ji H,Li T

更新日期：2020-07-01 00:00:00

abstract：:Abacavir (ZIAGEN) is a reverse transcriptase inhibitor marketed for the treatment of HIV-1 infection. A small percentage of patients experience a hypersensitivity reaction indicating immune system involvement and bioactivation. A major route of metabolism for abacavir is oxidation of a primary betagamma unsaturated al...

journal_title：Chemico-biological interactions

authors： Walsh JS,Reese MJ,Thurmond LM

更新日期：2002-11-10 00:00:00

abstract：:Butyrylcholinesterase (BChE) has proven to be an effective bioscavenger against nerve agents and organophosphates. Phase I safety trials of human BChE are currently being conducted and large-scale production of recombinant BChE is underway. Information on the real-time distribution of BChE from the injection site has ...

journal_title：Chemico-biological interactions

authors： Duysen EG,Lockridge O

更新日期：2008-09-25 00:00:00

abstract：:In cancer, a high flux of oxidants not only depletes the cellular thiols, but damages the whole cell as well. Epidemiological studies suggest green tea may mitigate cancers in human and animal models for which several mechanisms have been proposed. In the present investigation, the levels of cellular thiols such as re...

journal_title：Chemico-biological interactions

authors： Srinivasan P,Sabitha KE,Shyamaladevi CS

更新日期：2004-10-15 00:00:00

abstract：:In humans, the aldehyde dehydrogenase superfamily consists of 19 isoenzymes which mostly catalyze the NAD(P)(+)-dependent oxidation of aldehydes. Many of these isoenzymes have overlapping substrate specificities and therefore their potential physiological functions may overlap. Thus the development of new isoenzyme-se...

journal_title：Chemico-biological interactions

authors： Buchman CD,Mahalingan KK,Hurley TD

更新日期：2015-06-05 00:00:00

abstract：:The cytostatic drug 6-mercaptopurine riboside (6-MPr) was investigated in mice in order to test the hypothesis that the teratogenicity of this antimetabolite is paralleled by an incorporation into the DNA of the embryos during organogenesis. DNA modification in the embryos was analysed 4 h following s.c. administratio...

journal_title：Chemico-biological interactions

authors： Platzek T,Schwabe R,Rahm U,Bochert G

更新日期：1994-10-01 00:00:00

abstract：:Scoulerine, an isoquinoline alkaloid isolated from Corydalis plants, has been reported to possess potent anti-proliferative and pro-apoptotic function in cancer cells. However, the effects and underlying mechanisms of scoulerine on colorectal cancer (CRC) progression remain elusive. CCK-8 and LDH assays were used to e...

journal_title：Chemico-biological interactions

authors： Tian J,Mo J,Xu L,Zhang R,Qiao Y,Liu B,Jiang L,Ma S,Shi G

更新日期：2020-08-25 00:00:00

abstract：:The objectives of the present work were to study the effects of certain peroxisome proliferators on xenobiotic-metabolizing enzyme activities in the testes of normal and hypothyroid rats, i.e. phenol sulfotransferases (pST), phenol UDP-glucuronosyl transferases (pUDPGT), glutathione transferases (GST), catalase, epoxi...

journal_title：Chemico-biological interactions

authors： Mehrotra K,Morgenstern R,Lundqvist G,Becedas L,Bengtsson Ahlberg M,Georgellis A

更新日期：1997-05-02 00:00:00

abstract：:Human galactokinase (GALK) is the first enzyme in the Leloir pathway, converting α-d-galactose into galactose-1-phosphate (Gal-1-P). Recently, there is increasing interest in targeting GALK as a novel therapy to ameliorate the disease manifestations in patients with Classic Galactosemia as it would, in combination wit...

journal_title：Chemico-biological interactions

authors： Tang M,Wierenga K,Elsas LJ,Lai K

更新日期：2010-12-05 00:00:00

abstract：:Andrographolide (Andro), a diterpenoid lactone isolated from a traditional herbal medicine Andrographis paniculata, is known to possess multiple pharmacological activities. In our previous study, Andro had been shown to have potent anti-cancer activity against human colorectal carcinoma Lovo cells by inhibiting cell-c...

journal_title：Chemico-biological interactions

authors： Shi MD,Lin HH,Chiang TA,Tsai LY,Tsai SM,Lee YC,Chen JH

更新日期：2009-08-14 00:00:00

abstract：:The distribution and metabolism of the environmental pollutant 1-nitropyrene was studied in C57B1/6N mice following oral or intraperitoneal dosing. When administered by gavage, 1-nitropyrene and its metabolites demonstrated biphasic elimination kinetics from the blood, with half-lives of 0.3 and 1.8 days and a distrib...

journal_title：Chemico-biological interactions

authors： Howard PC,Consolo MC,Dooley KL,Beland FA

更新日期：1995-04-14 00:00:00

abstract：:Previously we reported that methylsulphonyl-2,6-dichlorobenzene, 2, 6-(diCl-MeSO(2)-B), was irreversibly bound to the olfactory mucosa of mice and induced necrosis of the Bowman's glands with subsequent neuroepithelial degeneration and detachment. In this study, autoradiography and histopathology were used to determin...

journal_title：Chemico-biological interactions

authors： Bahrami F,van Hezik C,Bergman A,Brandt I

更新日期：2000-10-16 00:00:00

abstract：:Nicorandil ameliorated doxorubicin-induced nephrotoxicity; this study aimed to show and explain the mechanism of this protection. A precise method was elucidated to study the effect of nicorandil on doxorubicin-induced nephrotoxicity in rats depending on the critical inflammation pathway TLR4/MAPK P38/NFκ-B. Adult mal...

journal_title：Chemico-biological interactions

authors： Khames A,Khalaf MM,Gad AM,Abd El-Raouf OM,Kandeil MA

更新日期：2019-09-25 00:00:00

abstract：:Addition of the tumor promoter phorbol myristate acetate to polymorphonuclear leukocytes results in the oxidation of the arylamine carcinogens; [14C]benzidine, N-[14C]methylaminoazobenzene and [14C]aminofluorene to reactive intermediate(s) that bind irreversibly to the leukocyte DNA. The binding was dependent on oxyge...

journal_title：Chemico-biological interactions

authors： Tsuruta Y,Subrahmanyam VV,Marshall W,O'Brien PJ

更新日期：1985-02-01 00:00:00

abstract：:The effects of various factors, including population doubling number, percent of confluence, serum concentration and storage in liquid nitrogen on the binding of several polycyclic aromatic hydrocarbons to human and hamster embryo cells were studied. The binding of 7,12-dimethylbenz[a]-anthracene (DMBA) to hamster emb...

journal_title：Chemico-biological interactions

authors： Raineri R,Poiley JA,Hillesund T,Pienta RJ

更新日期：1978-09-01 00:00:00

abstract：:Malondialdehyde (MDA) in urine was measured as a 2,4-dinitrophenylhydrazine (DNPH) derivative using high-performance liquid chromatography (HPLC) for the analysis. MDA standard coeluted with a peak obtained from rat urine after i.p. administration of MDA standard. This peak was also the only peak containing 14C after ...

journal_title：Chemico-biological interactions

authors： Ekström T,Garberg P,Egestad B,Högberg J

更新日期：1988-01-01 00:00:00

abstract：:Bitumens contain traces of polycyclic aromatic compounds (PACs), a part of which will end up in the fumes emitted during hot handling of bitumen-containing products, e.g. during roadpaving. Although exposure of workers to these fumes is low, it might lead to health problems. Studies on bitumen fume condensates (BFCs) ...

journal_title：Chemico-biological interactions

authors： De Méo M,Genevois C,Brandt H,Laget M,Bartsch H,Castegnaro M

更新日期：1996-08-14 00:00:00

abstract：:We investigated the chemopreventive effect of p-methoxycinnamic acid (p-MCA), an active phenolic acid of rice bran, turmeric, and Kaemperfia galanga against 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Male albino Wistar rats were randomly divided into six groups. Group 1 consisted of control rats that rece...

journal_title：Chemico-biological interactions

authors： Sivagami G,Karthikkumar V,Balasubramanian T,Nalini N

更新日期：2012-03-05 00:00:00

abstract：:This study examines the relationship between cell progress into the state of unbalanced growth, hydrolytic enzyme activities and cell survival during the exposure of L5178Y cells to hydroxyurea (HU), excess thymidine (dThR), hydroxyurea with excess of four deoxyribonucleosides (dNR) or excess dTHR with deoxycytidine (...

journal_title：Chemico-biological interactions

authors： Malec J,Przybyszewski WM,Grabarczyk M,Sitarska E,Czartoryska B

更新日期：1986-03-01 00:00:00

abstract：:Evidence for the reversible binding of paraquat to calf thymus DNA has been obtained using equilibrium dialysis and thermal melting point determinations. The data indicated the presence of at least two populations of binding site with affinity constants of 6.2 X 10(4) and 7.1 X 10(3) M-1, respectively. The binding cap...

journal_title：Chemico-biological interactions

authors： Minchin RF

更新日期：1987-02-01 00:00:00

abstract：:Rutin possesses multiple pharmacological activities, including the cardioprotective effect. The present study aimed to evaluate the protective effects of rutin on hypoxia/reoxygenation (H/R)-induced myocardial injury and its underlying mechanism involved. H9c2 cells were pretreated with 50 μM rutin or combined with 1 ...

journal_title：Chemico-biological interactions

authors： Yang H,Wang C,Zhang L,Lv J,Ni H

更新日期：2019-01-05 00:00:00