Abstract:
:5-Iodouracil (IUra)-substituted progeny bacteriophage T4td8 were grown under conditions such that, upon CsCl equilibrium isopycnic gradient centrifugation, progeny with density distributions about the median similar to that of unsubstituted phage are obtained. In the absence of light a monotonic relationship exists between decreasing progeny viability and increasing percent IUra substitution. IUra is equivalent to thymine as a growth factor on a molar basis, and at concentrations of IUra plus thymine above that required for maximum particle production, the percent IUra substitution in phage DNA is determined by the mole fraction of IUra in the medium. The lethal effects of 5-iodo-2'-deoxyuridine (IdUrd) and IUra are equivalent, and are not produced by a direct effect on the phage particles. At equivalent percent substitution in phage DNA the order of lethality is IUra greater than 5-bromouracil (BrUra) greater than 5-chlorouracil (ClUra). There is no interference with the transfer of thymine from host cell to progeny phage by the presence of IUra in the medium, and IUra affects neither the time of lysis nor the content of phage DNA in the infected cells.
journal_name
Chem Biol Interactjournal_title
Chemico-biological interactionsauthors
Byrd DM,Prusoff WHdoi
10.1016/0009-2797(76)90099-5subject
Has Abstractpub_date
1976-02-01 00:00:00pages
197-210issue
2eissn
0009-2797issn
1872-7786pii
0009-2797(76)90099-5journal_volume
12pub_type
杂志文章abstract::The functional genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) influences the enzymatic activities of its wild type (Glu504 encoded by ALDH2*1) and mutant type (Lys504 encoded by ALDH2*2) proteins. The enzymatic activities of mutant-type ALDH2 are limited compared with those of the wild type. ALDH2 has been s...
journal_title:Chemico-biological interactions
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更新日期:2017-10-01 00:00:00
abstract::Addition of the tumor promoter phorbol myristate acetate to polymorphonuclear leukocytes results in the oxidation of the arylamine carcinogens; [14C]benzidine, N-[14C]methylaminoazobenzene and [14C]aminofluorene to reactive intermediate(s) that bind irreversibly to the leukocyte DNA. The binding was dependent on oxyge...
journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/s0009-2797(85)80081-8
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journal_title:Chemico-biological interactions
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journal_title:Chemico-biological interactions
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更新日期:2015-09-05 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2016.09.003
更新日期:2016-10-25 00:00:00
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journal_title:Chemico-biological interactions
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更新日期:2019-04-25 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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更新日期:1983-08-01 00:00:00
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journal_title:Chemico-biological interactions
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doi:10.1016/j.cbi.2007.09.001
更新日期:2008-01-10 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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更新日期:1981-10-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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更新日期:1982-04-01 00:00:00
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journal_title:Chemico-biological interactions
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doi:10.1016/j.cbi.2020.109354
更新日期:2021-01-25 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2017.03.006
更新日期:2017-10-01 00:00:00
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journal_title:Chemico-biological interactions
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更新日期:2020-12-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2012.08.015
更新日期:2013-03-25 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 历史文章,杂志文章
doi:10.1016/j.cbi.2005.03.009
更新日期:2005-05-30 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/0009-2797(80)90054-x
更新日期:1980-06-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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更新日期:1981-08-01 00:00:00
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journal_title:Chemico-biological interactions
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doi:10.1016/j.cbi.2010.04.005
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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更新日期:1978-09-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/0009-2797(79)90008-5
更新日期:1979-02-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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更新日期:2019-02-25 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 评论,信件
doi:10.1016/j.cbi.2014.10.010
更新日期:2014-10-05 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2009.11.022
更新日期:2010-02-12 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2005.10.031
更新日期:2005-12-15 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2008.04.001
更新日期:2008-09-25 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2012.10.016
更新日期:2013-03-25 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/0009-2797(92)90093-z
更新日期:1992-06-15 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章,评审
doi:10.1016/j.cbi.2010.10.004
更新日期:2011-06-30 00:00:00