Abstract:
:Disodium cromoglycate (DSCG) in equimolar concentration of 0.56 mumol/l preincubated with an asynchronous cell population decreases the inhibition of proliferation and results in a 100% elimination of inhibition of colony formation induced by benfluron (BF). DSCG protects the cells from unbalanced growth and unbalanced metabolism (e.g., prevention of increase or decrease in protein cell content, glycolytic activity and in amino acid metabolism) which are both the integrating parts of BF cytotoxic reaction. The protective effect of DSCG is manifested also on synchronous cell populations, particularly in G2 phase (26%). DSCG also stabilizes cell membrane by preventing the alterations of its permeability caused by the cytolytic concentrations of benfluron (at a concentration of 1.05 mumol/l and more).
journal_name
Chem Biol Interactjournal_title
Chemico-biological interactionsauthors
Horáková K,Vlcková A,Lukácová Ddoi
10.1016/0009-2797(93)90002-gsubject
Has Abstractpub_date
1993-12-01 00:00:00pages
103-13issue
2-3eissn
0009-2797issn
1872-7786pii
0009-2797(93)90002-Gjournal_volume
89pub_type
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