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Protection of radiation induced DNA and membrane damages by total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst.

Abstract：

:The total triterpenes isolated from the fruiting bodies of Ganoderma lucidum was examined for its potential to prevent γ-radiation induced membrane damage in rat liver mitochondria and microsomes. The effects of total triterpenes on γ-radiation-induced DNA strand breaks in pBR 322 plasmid DNA in vitro and human peripheral blood lymphocytes ex vivo were evaluated. The protective effect of total triterpenes against γ-radiation-induced micronuclei formations in mice bone marrow cells in vivo were also evaluated. The results indicated the significant effectiveness of Ganoderma triterpenes in protecting the DNA and membrane damages consequent to the hazardous effects of radiation. The findings suggest the potential use of Ganoderma triterpenes in radio therapy.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Smina TP,Maurya DK,Devasagayam TP,Janardhanan KK

doi

10.1016/j.cbi.2015.03.019

subject

Has Abstract

pub_date

2015-05-25 00:00:00

pages

1-7

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(15)00118-0

journal_volume

233

pub_type

杂志文章

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