The time course of DNA repair following methyl nitro-nitrosoguanidine (MNNG) treatment of p388f lymphoma cells in culture. II. DNA repair synthesis and its correlation with strand breakage.

Abstract:

:Repair synthesis has been followed in P388F cell DNA following treatment with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) using 5-iodo-deoxyuridine (IUdR) and [3H] thymidine combination. A pattern of repair synthesis was obtained, similar in its timing to the initial and medial stages of single-strand break formation and rejoining within the first 24 h after treatment. A higher base insertion frequency in relation to single-strand breaks occurs during the medial stage of repair. However, a fundamental problem with the use of iododeoxyuridine and [3H] thymidine ([3H] TdR) as a suitable measure of repair synthesis was encountered and a potential source of error in such experiments was observed.

journal_name

Chem Biol Interact

authors

Nikaido O,Fox BW

doi

10.1016/0009-2797(76)90023-5

subject

Has Abstract

pub_date

1976-07-01 00:00:00

pages

47-55

issue

1-2

eissn

0009-2797

issn

1872-7786

pii

0009-2797(76)90023-5

journal_volume

14

pub_type

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