Multiple mechanisms of cell death induced by chelidonine in MCF-7 breast cancer cell line.

abstract：:2-Hydroxy-3',5,5'-trimethoxychalcone (named DK-139) is a synthetic chalcone derivative that has anti-inflammatory, anti-tumor, and endoplasmic reticulum-mediated apoptosis activities. However, the mode of action of DK-139 on reactive oxygen species (ROS)-induced apoptosis remains unknown. In this study, we found that ...

journal_title：Chemico-biological interactions

authors： Gil HN,Jung E,Koh D,Lim Y,Lee YH,Shin SY

更新日期：2019-01-25 00:00:00

abstract：:We have investigated the activation of p-cresol to form DNA adducts using horseradish peroxidase, rat liver microsomes and MnO(2). In vitro activation of p-cresol with horseradish peroxidase produced six DNA adducts with a relative adduct level of 8.03+/-0.43 x 10(-7). The formation of DNA adducts by oxidation of p-cr...

journal_title：Chemico-biological interactions

authors： Gaikwad NW,Bodell WJ

更新日期：2001-12-21 00:00:00

abstract：:To evaluate the protective role of cell glutathione (GSH) against the toxicity of cadmium, the effect of GSH depletion on the metal toxicity was investigated and the role of glutathione was compared with that of zinc-induced metallothioneins (MTs). A 6-h incubation of cultured Chinese hamster V79 cells with 0.2 mM L-b...

journal_title：Chemico-biological interactions

authors： Ochi T,Otsuka F,Takahashi K,Ohsawa M

更新日期：1988-01-01 00:00:00

abstract：:The 2 pH dependent peaks formed in the Soret region by the treatment of reduced hepatic microsomes or purified cytochrome P-448 with ethyl isocyanide do not exhibit identical dependence on ethyl isocyanide concentration. This behavior and other facts regarding double Soret spectra can be explained by a simple expostul...

journal_title：Chemico-biological interactions

authors： Dahl AR,Hodgson E

更新日期：1978-02-01 00:00:00

abstract：:The role of catecholamines in the toxicity of MPTP (N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine) was explored. The killing of cultured hepatocytes by dopamine and 6-hydroxydopamine was enhanced following inhibition of glutathione reductase by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a manipulation known to sensi...

journal_title：Chemico-biological interactions

authors： Snyder JW,Alexander GM,Ferraro TN,Grothusen JR,Farber JL

更新日期：1993-09-01 00:00:00

abstract：:The carcinogenic activity of the synthetic estrogen hexestrol was measured in male Syrian hamsters. Between 90% and 100% of the animals treated with hexestrol or with 3',3",5',5"-tetradeuteriohexestrol, implanted subcutaneously as 25-mg pellets, were found with renal carcinoma after 6-7 months. In vitro hexestrol meta...

journal_title：Chemico-biological interactions

authors： Liehr JG,Ballatore AM,Dague BB,Ulubelen AA

更新日期：1985-10-01 00:00:00

abstract：:Catalytic scavengers of organophosphates (OPs) are considered very promising antidote candidates for preventing the adverse effects of OP intoxication as stand alone treatments. This study aimed at correlating the in-vivo catalytic efficiency ((kcat/KM)[Enzyme]pl), established prior to the OP challenge, with the sever...

journal_title：Chemico-biological interactions

authors： Ashani Y,Leader H,Aggarwal N,Silman I,Worek F,Sussman JL,Goldsmith M

更新日期：2016-11-25 00:00:00

abstract：:Chronic exposure of humans to benzene causes severe bone marrow cell depression leading to aplastic anemia. Marrow stromal macrophage dysfunction and deficient interleukin-1 production has been reported for patients with severe aplastic anemia. The stromal macrophage, a target of benzene toxicity, is involved in hemat...

journal_title：Chemico-biological interactions

authors： Niculescu R,Bradford HN,Colman RW,Kalf GF

更新日期：1995-12-22 00:00:00

abstract：:Butyrylcholinesterase (BChE) is coded by the BCHE gene that presents four exons. The non-codifying exon 1 presents two variants -116G and -116A, being -116A preferentially in cis conformation with the 539T variant (K) of exon 4 which was associated with lower BChE activity and lower body mass index (BMI) variance. Thi...

journal_title：Chemico-biological interactions

authors： Furtado-Alle L,Andrade FA,Nunes K,Mikami LR,Souza RL,Chautard-Freire-Maia EA

更新日期：2008-09-25 00:00:00

abstract：:Treatment of rats with the aminonucleoside of puromycin, which increases the incorporation of labelled phenylalanyl-tRNA into polypeptide chains in liver ribosome preparations studied in vitro, did not change the factor-dependent binding of fMet-tRNA f Met to ribosomes nor the peptidyl transferase function of the ribo...

journal_title：Chemico-biological interactions

authors： Innanen VT,Nicholls DM

更新日期：1975-11-01 00:00:00

abstract：:Two diol epoxides of benzo(a)pyrene (BP), and benzo(a)pyrene 4,5-oxide, have been used to make adducts in the homopolymers polyribocytidylic acid, (rC); polyriboadenylic acid (rA), polydeoxycytidylic acid (dC) and polydeoxyadenylic acid (dA). With appropriate oligomers as primers these modified and unmodified polynucl...

journal_title：Chemico-biological interactions

authors： Yamaura I,Marquardt H,Cavalieri LF

更新日期：1978-12-01 00:00:00

abstract：:Recombinant (r) and native butyrylcholinesterse (BChE) are potent bioscavengers of organophosphates (OPs) such as nerve agents and pesticides and are undergoing development as antidotal treatments for OP-induced toxicity. Because of the lethal properties of such agents, regulatory approval will require extensive testi...

journal_title：Chemico-biological interactions

authors： Rosenberg YJ,Adams RJ,Hernandez-Abanto S,Jiang X,Sun W,Mao L,Lee KD

更新日期：2015-12-05 00:00:00

abstract：:The 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethene (DDT) metabolic intermediate 1-chloro-2,2-bis(p-chlorophenyl)ethene (DDMU) is partially metabolized in vivo by mice to 2-hydroxy-2,2-bis(p-chlorophenyl)acetic acid (alpha OH-DDA) and other metabolites which are excreted in urine. The subsequent DDT metabolic intermedia...

journal_title：Chemico-biological interactions

authors： Gold B,Leuschen T,Brunk G,Gingell R

更新日期：1981-05-01 00:00:00

abstract：:To determine correlations between the biological action pattern and chemical reactivity of alkylating agents, the rate constants for reactions of 1,3-propane sultone and 1,4-butane sultone with a series of nucleophiles at 37 degrees C have been determined. Previously published data on the mutagenicity of the two sulto...

journal_title：Chemico-biological interactions

authors： Osterman-Golkar S,Wachtmeister CA

更新日期：1976-07-01 00:00:00

abstract：:Alcohol dehydrogenase 3 (ADH3) has emerged as an important regulator of protein S-nitrosation in its function as S-nitrosoglutathione (GSNO) reductase. GSNO depletion is associated with various disease conditions, emphasizing the potential value of a specific ADH3 inhibitor. The present study investigated inhibition o...

journal_title：Chemico-biological interactions

authors： Staab CA,Hellgren M,Grafström RC,Höög JO

更新日期：2009-06-15 00:00:00

abstract：:P-glycoprotein (P-gp) is a membranous ATPase responsible for the multidrug resistance phenotype. The effect on P-gp-mediated transport of anthracyclines of cell irradiation in the presence of 2,2-diphenyl-5-[N-1-(o-azidophenyl)ethylamino]valeronitrile (VP*), a photoactivable analogue of verapamil was studied in viable...

journal_title：Chemico-biological interactions

authors： Mankhetkorn S,Teodori E,Garnier-Suillerot A

更新日期：1999-07-01 00:00:00

abstract：:Cysteine (Cys) residues are often crucial to the function and structure of proteins. Cys157 and Cys207 in recombinant mouse arsenic (+3 oxidation state) methyltransferase (AS3MT) are shown to be related to enzyme activity and considered to be the catalytic sites. The roles of some conserved Cys residues in the N-termi...

journal_title：Chemico-biological interactions

authors： Song X,Geng Z,Zhu J,Li C,Hu X,Bian N,Zhang X,Wang Z

更新日期：2009-05-15 00:00:00

abstract：:The lipopolysaccharide (LPS)-Toll-like receptor 4 (TLR4) signaling pathway in alveolar epithelial cells plays an important role in many pathologic processes such as acute lung injury (ALI). The single immunoglobulin IL-1 receptor-related protein (SIGIRR) is an inhibitor of LPS-TLR4 signaling, but its expression and fu...

journal_title：Chemico-biological interactions

authors： Feng T,Yunfeng N,Jinbo Z,Zhipei Z,Huizhong Z,Li L,Tao J,Yunjie W

更新日期：2010-02-12 00:00:00

abstract：:Nicotine exposure increases the release of glutamate in part through stimulatory effects on pre-synaptic nicotinic acetylcholine receptors (nAChRs). To assess the impact of chronic electronic (e)-cigarette use on these drug dependence pathways, we exposed C57BL/6 mice to three types of inhalant exposures for 3 months;...

journal_title：Chemico-biological interactions

authors： Alasmari F,Crotty Alexander LE,Hammad AM,Horton A,Alhaddad H,Schiefer IT,Shin J,Moshensky A,Sari Y

更新日期：2021-01-05 00:00:00

abstract：:Studies were undertaken to investigate the mechanism of bioactivation and covalent binding of TNT. Incubation of [14C]TNT with rat liver microsomes in the presence of an NADPH generating system resulted in metabolism and covalent binding to microsomal proteins. Time-dependence studies showed that TNT was rapidly reduc...

journal_title：Chemico-biological interactions

authors： Leung KH,Yao M,Stearns R,Chiu SH

更新日期：1995-06-30 00:00:00

abstract：:Due to its antiviral effects and its importance for all immunological functions, the administration of selenium is suggested as a supportive measure in early as well as in advanced stages of HIV-induced disease. Initial observations on the effects of selenium supplementation in HIV-infected patients indicate that sele...

journal_title：Chemico-biological interactions

authors： Schrauzer GN,Sacher J

更新日期：1994-06-01 00:00:00

abstract：:Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhiz...

journal_title：Chemico-biological interactions

authors： Song N,Zhao Z,Ma X,Sun X,Ma J,Li F,Sun L,Lv J

更新日期：2017-01-05 00:00:00

abstract：:S-(2,5-Dihydroxyphenyl)-cysteine and S-(2,5-dihydroxyphenyl)-N-acetyl-cysteine [the cysteine- and N-acetyl-cysteine adducts, respectively, of hydroquinone (HQ)] were identified and quantified in the urine of mice administered [ring-U-14C]acetaminophen [14C]APAP, 200 mg kg-1, i.p.). Urine was collected for 24 h and fra...

journal_title：Chemico-biological interactions

authors： Pascoe GA,Calleman CJ,Baille TA

更新日期：1988-01-01 00:00:00

abstract：:This study is aimed to investigate whether Mabuterol (Mab) inhibits proliferation of airway smooth muscle cells (ASMCs) induced by platelet-derived growth factor BB (PDGF-BB) and how far it is related to mitochondrial fission/fusion and intracellular calcium if it comes into play. To explore the mechanism of Mab's ant...

journal_title：Chemico-biological interactions

authors： Gu Y,Yu X,Li X,Wang X,Gao X,Wang M,Wang S,Li X,Zhang Y

更新日期：2019-07-01 00:00:00

abstract：:The cDNA for human liver phenol-sulfating phenol sulfotransferase (P-PST) has been cloned and the active enzyme expressed in Cos cells and bacteria. Analysis of the sequence identified two cysteine residues, one of which is highly conserved in the phenol sulfotransferase gene family. Previous studies with the pure hum...

journal_title：Chemico-biological interactions

authors： Falany CN,Zhuang W,Falany JL

更新日期：1994-06-01 00:00:00

abstract：:Hispidulin, a natural flavone, has been reported to have diverse pharmacological effects, including antifungal, antioxidant, and antithrombotic properties. However, an anti-adipogenic effect has not yet been reported, which is the focus of the current study. Hispidulin suppressed the differentiation of adipocytes and ...

journal_title：Chemico-biological interactions

authors： Lee SG,Kim JS,Min K,Kwon TK,Nam JO

更新日期：2018-09-25 00:00:00

abstract：:6-Shogaol, a potent bioactive compound in ginger (Zingiber officinale Roscoe), has been reported for anti-inflammatory and anti-cancer activity. In this study, we investigated the effect of 6-shogaol to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. The combined treatment w...

journal_title：Chemico-biological interactions

authors： Han MA,Woo SM,Min KJ,Kim S,Park JW,Kim DE,Kim SH,Choi YH,Kwon TK

更新日期：2015-02-25 00:00:00

abstract：:Benzene exposure in occupational settings often occurs with concurrent exposure to toluene, the methyl-substituted derivative of benzene. Toluene is also readily metabolized by CYP450 isozymes although oxidation primarily occurs in the methyl group. While earlier mouse studies addressing co-exposure to benzene and tol...

journal_title：Chemico-biological interactions

authors： Bird MG,Wetmore BA,Letinski DJ,Nicolich M,Chen M,Schnatter AR,Whitman FT

更新日期：2010-03-19 00:00:00

abstract：:Carbonyl reductase (CR) is an enzyme which can catalyze the oxidoreduction of various carbonyl compounds in the presence of NAD(P)H. With the PCR method, using primers carrying the conserved nucleotide sequence among mammalian CRs, we isolated three different cDNAs (CHCR1, CHCR2 and CHCR3) which encode a unique carbon...

journal_title：Chemico-biological interactions

authors： Terada T,Sugihara Y,Nakamura K,Sato R,Sakuma S,Fujimoto Y,Fujita T,Inazu N,Maeda M

更新日期：2001-01-30 00:00:00

abstract：:A common method to assess exposure to 1,3-butadiene through both occupational and environmental routes involves the detection of hemoglobin adducts formed by the primary reactive metabolite butadiene monoxide (EB). This assay is a modification of the Edman degradation procedure, which was developed to determine adduct...

journal_title：Chemico-biological interactions

authors： Moll TS,Harms AC,Elfarra AA

更新日期：2001-06-01 00:00:00