The affinity of cytochrome P-450 for ethyl isocyanide: an explanation of double soret spectra.

Abstract:

:The 2 pH dependent peaks formed in the Soret region by the treatment of reduced hepatic microsomes or purified cytochrome P-448 with ethyl isocyanide do not exhibit identical dependence on ethyl isocyanide concentration. This behavior and other facts regarding double Soret spectra can be explained by a simple expostulation involving lipophilic and corrdinate binding of pi-acceptor ligands.

journal_name

Chem Biol Interact

authors

Dahl AR,Hodgson E

doi

10.1016/0009-2797(78)90051-0

subject

Has Abstract

pub_date

1978-02-01 00:00:00

pages

171-80

issue

2

eissn

0009-2797

issn

1872-7786

pii

0009-2797(78)90051-0

journal_volume

20

pub_type

杂志文章
  • Vasodilatory effect of nitroglycerin in Japanese subjects with different aldehyde dehydrogenase 2 (ALDH2) genotypes.

    abstract::The functional genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) influences the enzymatic activities of its wild type (Glu504 encoded by ALDH2*1) and mutant type (Lys504 encoded by ALDH2*2) proteins. The enzymatic activities of mutant-type ALDH2 are limited compared with those of the wild type. ALDH2 has been s...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2017.03.012

    authors: Miura T,Nishinaka T,Terada T,Yonezawa K

    更新日期:2017-10-01 00:00:00

  • The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents.

    abstract::Acetylcholinesterase (AChE) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. The reversible inhibition of AChE was suggested as the pre-treatment option of the intoxications caused by nerve agents. Based on our derived 3D-QSAR model ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2019.06.027

    authors: Vitorović-Todorović MD,Worek F,Perdih A,Bauk SĐ,Vujatović TB,Cvijetić IN

    更新日期:2019-08-25 00:00:00

  • Acute dieldrin toxicity: effect on the uptake of glucose and leucine and on brush border enzymes in monkey intestine.

    abstract::Administration of a single oral dose of dieldrin (20 mg/kg body wt.) to rhesus monkeys considerably elevated the uptake of glucose and the activities of brush border sucrase, lactase, maltase and alkaline phosphatase in intestine compared to control animals. Leucine uptake and leucine amino peptidase activity was sign...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(81)90173-3

    authors: Mahmood A,Agarwal N,Sanyal S,Dudeja PK,Subrahmanyam D

    更新日期:1981-10-01 00:00:00

  • Studies on rat hepatic hydroxysteroid sulfotransferase--immunochemistry, development and pI variants.

    abstract::Rat hepatic hydroxysteroid sulfotransferase with sulfoconjugates androsterone (androsterone-sulfating sulfotransferase) is an oligomer consisting of several subunits with distinct pI values but with the same molecular mass (pI variants). N-terminal amino acid sequences of the pI variants are all identical. The enzyme ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(94)90049-3

    authors: Homma H,Nakagome I,Kamakura M,Hirota M,Takahashi M,Matsui M

    更新日期:1994-06-01 00:00:00

  • Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase.

    abstract::Anthracyclines (ANTs) are widely used in the treatment of various forms of cancer. Although their usage contributes to an improvement in life expectancy, it is limited by severe adverse effects-acute and chronic cardiotoxicity. Several enzymes from both AKR and SDR superfamilies have been reported as participants in t...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2010.12.016

    authors: Skarka A,Skarydová L,Stambergová H,Wsól V

    更新日期:2011-05-30 00:00:00

  • Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes.

    abstract::Recent studies have demonstrated the potential of pesticides to either inhibit or induce xenobiotic metabolizing enzymes in humans. Exposure of human hepatocytes to doses of fipronil (5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl) sulfinyl]-1H-pyrazole-3-carbonitrile) ranging from 0.1 to 25 mi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2006.09.013

    authors: Das PC,Cao Y,Cherrington N,Hodgson E,Rose RL

    更新日期:2006-12-15 00:00:00

  • The impact of skin decontamination on the time window for effective treatment of percutaneous VX exposure.

    abstract::The main goal of the present study was to obtain insight into depot formation and penetration following percutaneous VX poisoning, in order to identify an appropriate decontamination window that can enhance or support medical countermeasures. The study was executed in two phases, using the hairless guinea pig as an an...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2016.02.001

    authors: Joosen MJ,van den Berg RM,de Jong AL,van der Schans MJ,Noort D,Langenberg JP

    更新日期:2017-04-01 00:00:00

  • Nicorandil combats doxorubicin-induced nephrotoxicity via amendment of TLR4/P38 MAPK/NFκ-B signaling pathway.

    abstract::Nicorandil ameliorated doxorubicin-induced nephrotoxicity; this study aimed to show and explain the mechanism of this protection. A precise method was elucidated to study the effect of nicorandil on doxorubicin-induced nephrotoxicity in rats depending on the critical inflammation pathway TLR4/MAPK P38/NFκ-B. Adult mal...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2019.108777

    authors: Khames A,Khalaf MM,Gad AM,Abd El-Raouf OM,Kandeil MA

    更新日期:2019-09-25 00:00:00

  • Conjugation of anti-dihydrodiol epoxides of benzo[a]pyrene, chrysene, benzo[c]phenanthrene and dibenz[a,h]anthracene with glutathione catalyzed by cytosol and by the Mu-class glutathione transferase HTP II from rat liver.

    abstract::The (+/-)-anti-dihydrodiol epoxides (DE) of benzo[a]pyrene (BP), chrysene (Chr), benzo[c]phenanthrene (BcPh) and dibenz[a,h]anthracene (DBA) were incubated in the presence of glutathione (GSH) with hepatic cytosol from untreated and Aroclor 1254 pretreated rats and with the Mu-class glutathione transferase (GST) HTP I...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(94)03357-9

    authors: Funk M,Gath I,Seidel A,Oesch F,Platt KL

    更新日期:1995-03-30 00:00:00

  • Effect of aflatoxins on oxidative phosphorylation by rat liver mitochondria.

    abstract::The in vitro effect of aflatoxins M1, B1 and G1 on oxidative phosphorylation by rat liver mitochondria with succinate as substrate has been studied. All these toxins inhibit the electron transport chain at a 1-10-4 M concentration and the site of inhibition is between cytochrome b and cytochrome c or c1. Aflatoxin M1 ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(75)90106-4

    authors: Ramachandra Pai M,Jayanthi Bai N,Venkitasubramanian TA

    更新日期:1975-02-01 00:00:00

  • Lead exposure inhibits osteoblastic differentiation and inactivates the canonical Wnt signal and recovery by icaritin in MC3T3-E1 subclone 14 cells.

    abstract::Exposure to lead (Pb) poses a threat to human bone health, including changes in bone mineral composition and the inhibition of skeletal growth and bone maturation. However, little is known about how Pb directly affects osteoblasts. In this work, we found that sub-toxic Pb concentrations suppressed bone nodule formatio...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2019.01.039

    authors: Sun K,Mei W,Mo S,Xin L,Lei X,Huang M,Chen Q,Han L,Zhu X

    更新日期:2019-04-25 00:00:00

  • Functions and distribution of NQO1 in human bone marrow: potential clues to benzene toxicity.

    abstract::NADPH:quinone oxidoreductase 1 (NQO1) may perform multiple functions within the cell. It is known to detoxify benzene-derived quinones and generate antioxidant forms of ubiquinone and Vitamin E. Recently suggested roles for NQO1 which may have relevance for mechanisms underlying benzene toxicity include modulation of ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbi.2005.03.018

    authors: Ross D

    更新日期:2005-05-30 00:00:00

  • Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae.

    abstract::Anopheles gambiae is the major mosquito vector of malaria in sub-Saharan Africa. At present, insecticide-treated nets (ITNs) impregnated with pyrethroid insecticides are widely used in malaria-endemic regions to reduce infection; however the emergence of pyrethroid-resistant mosquitoes has significantly reduced the ef...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2008.04.037

    authors: Carlier PR,Anderson TD,Wong DM,Hsu DC,Hartsel J,Ma M,Wong EA,Choudhury R,Lam PC,Totrov MM,Bloomquist JR

    更新日期:2008-09-25 00:00:00

  • Formic acid up-regulates vascular tension through nitric oxide-cGMP signaling pathway.

    abstract::Formic acid is a common organic acid used in many industrial processes. There is a paucity of research on the direct toxicity of formic acid and how it might affect the cardiovascular system. This study aimed to understand the effect of formic acid on vascular tension in an animal model and the underlying mechanism. R...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2019.06.023

    authors: Zhang Q,Niu Y,Lyu W,Yu M

    更新日期:2019-08-25 00:00:00

  • Hydroxyflavone metal complexes - molecular structure, antioxidant activity and biological effects.

    abstract::High content of hydroxyflavones in fruits, vegetables, cereals and herbs makes them a common component of the human diet. Because of their antioxidant, antiviral, antibacterial, anti-inflammatory, anticancer properties they still pay an attention of many scientific centers. Hydroxyflavones may form complexes with meta...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbi.2017.06.016

    authors: Samsonowicz M,Regulska E,Kalinowska M

    更新日期:2017-08-01 00:00:00

  • Chemical features of flavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents.

    abstract::Flavonls are natural compounds present in edible plants and possess several biological activities that can be useful in drug design. Conversely some of these compounds have been shown to be genotoxic to prokaryotic and eukaryotic cells. In this study we tried to establish the chemical features responsible for the geno...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/s0009-2797(99)00139-8

    authors: Silva ID,Gaspar J,da Costa GG,Rodrigues AS,Laires A,Rueff J

    更新日期:2000-01-03 00:00:00

  • PXR: Structure-specific activation by hepatotoxic pyrrolizidine alkaloids.

    abstract::Pyrrolizidine alkaloids (PAs) comprise a large group of more than 660 secondary metabolites found in more than 6000 plant species worldwide. Acute PA intoxication induces severe liver damage. Chronic exposure to sub-lethal doses may cause cumulative damage or cancer. Nuclear receptor activation often constitutes a mol...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2018.04.017

    authors: Luckert C,Braeuning A,Lampen A,Hessel-Pras S

    更新日期:2018-05-25 00:00:00

  • Molecular cloning of neuropathy target esterase (NTE).

    abstract::Covalent modification of NTE, a neuronal protein with serine esterase activity, by certain organophosphates (OP) initiates degeneration of long axons in the peripheral and central nervous system. Simple inhibition of NTE esterase activity does not initiate neuropathy; the latter requires aging of the OP bound to the c...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/s0009-2797(99)00065-4

    authors: Glynn P,Read DJ,Lush MJ,Li Y,Atkins J

    更新日期:1999-05-14 00:00:00

  • Potential anticancer activity of lichen secondary metabolite physodic acid.

    abstract::Secondary metabolites present in lichens, which comprise aliphatic, cycloaliphatic, aromatic and terpenic compounds, are unique with respect to those of higher plants and show interesting biological and pharmacological activities. However, only a few of these compounds, have been assessed for their effectiveness again...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2016.12.007

    authors: Cardile V,Graziano ACE,Avola R,Piovano M,Russo A

    更新日期:2017-02-01 00:00:00

  • Alkylation of DNA and hemoglobin in the mouse following exposure to propene and propylene oxide.

    abstract::Male CBA mice were exposed to propene, unlabelled or 14C-labelled, by inhalation, or to 14C-labelled propylene oxide by intraperitoneal injection. 2-Hydroxypropyl adducts to guanine-N-7 in DNA of various organs and to N-terminal valine and histidine-N pi in hemoglobin were measured. The adduct levels observed show tha...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(91)90102-d

    authors: Svensson K,Olofsson K,Osterman-Golkar S

    更新日期:1991-01-01 00:00:00

  • Inhibition of human prostatic tumour acid phosphatase by N,N-p-di-2-chloroethylaminophenol, N,N-p-di-2-chloroethylaminophenyl phosphate and other difunctional nitrogen mustards.

    abstract::Potent inhibition of human prostatic carcinoma tissue acid phosphatase by N,N-d-di-2-chloroethylaminophenol (AMOH) and N,N-p-di-2-chloroethylaminophenyl phosphate (AMPh) is described. Certain other difunctional nitrogen mustards were also inhibitory but N,N-p-di-2hydroxyethylaminophenol, the non-alkylating fully hydro...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(78)90085-6

    authors: Workman P

    更新日期:1978-01-01 00:00:00

  • In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications.

    abstract::Catalytic scavengers of organophosphates (OPs) are considered very promising antidote candidates for preventing the adverse effects of OP intoxication as stand alone treatments. This study aimed at correlating the in-vivo catalytic efficiency ((kcat/KM)[Enzyme]pl), established prior to the OP challenge, with the sever...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2016.04.039

    authors: Ashani Y,Leader H,Aggarwal N,Silman I,Worek F,Sussman JL,Goldsmith M

    更新日期:2016-11-25 00:00:00

  • Role of cytochrome P-450IIE1 in N-nitroso-N-methylaniline induced hepatocyte cytotoxicity.

    abstract::1. The cytotoxicity of N-nitrosomethylaniline (NMA) towards hepatocytes isolated from rats was prevented by acetone or ethanol (inhibitors for cytochrome P-450IIE1) but not by metyrapone or SKF525A (inhibitors for cytochrome P-450IIB1/2). Various alcohols, secondary ketones and isothiocyanates that induced cytochrome ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(92)90099-7

    authors: Quan Z,Khan S,O'Brien PJ

    更新日期:1992-08-28 00:00:00

  • LC-MS based metabolomics reveals metabolic pathway disturbance in retinal pigment epithelial cells exposed to hydroxychloroquine.

    abstract::Hydroxychloroquine (HCQ) is frequently used medications for many auto-immunity diseases. However, HCQ induced retinal toxicity, which might result in irreversible retinopathy, is one of the most important complications of HCQ. However, the molecular mechanism underlying the HCQ retinal toxicity is still not well known...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2020.109212

    authors: Li JH,Xu ZY,Li MJ,Zheng WL,Huang XM,Xiao F,Cui YH,Pan HW

    更新日期:2020-09-01 00:00:00

  • In vivo metabolism of nasally instilled dihydrosafrole [1-(3,4-methylenedioxyphenyl)propane] in dogs and monkeys.

    abstract::Nasal metabolism of inhaled material may influence its biological fate and toxicity. The purpose of this study was to investigate, in a noninvasive and qualitative manner, the in vivo nasal metabolic activity towards 1-(3,4-methylenedioxyphenyl)propane (dihydrosafrole). Dihydrosafrole was the compound of choice as a r...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/0009-2797(87)90056-1

    authors: Petridou-Fischer J,Whaley SL,Dahl AR

    更新日期:1987-01-01 00:00:00

  • Polymorphisms in the human AH receptor.

    abstract::The AH receptor (AHR) mediates toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as well as induction of three cytochrome P450 enzymes and certain Phase II enzymes. In laboratory animals, genetic variations in the AHR lead to substantial differences in sensitivity to biochemical and toxic effects of TCDD and rela...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审

    doi:10.1016/s0009-2797(02)00071-6

    authors: Harper PA,Wong Jm,Lam MS,Okey AB

    更新日期:2002-09-20 00:00:00

  • The fate of benzene-oxide.

    abstract::Metabolism is a prerequisite for the development of benzene-mediated myelotoxicity. Benzene is initially metabolized via cytochromes P450 (primarily CYP2E1 in liver) to benzene-oxide, which subsequently gives rise to a number of secondary products. Benzene-oxide equilibrates spontaneously with the corresponding oxepin...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2009.12.025

    authors: Monks TJ,Butterworth M,Lau SS

    更新日期:2010-03-19 00:00:00

  • Copper modifies liver microsomal UDP-glucuronyltransferase activity through different and opposite mechanisms.

    abstract::Treatment of hepatic microsomes with Fe(3+)/ascorbate activates UDP-glucuronyltransferase (UGT), a phenomenon totally prevented and reversed by reducing agents. At microM concentrations, iron and copper ions catalyze the formation of ROS through Fenton and/or Haber-Weiss reactions. Unlike iron ions, indiscriminate bin...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2006.12.010

    authors: Letelier ME,Lagos F,Faúndez M,Miranda D,Montoya M,Aracena-Parks P,González-Lira V

    更新日期:2007-04-05 00:00:00

  • Gallic acid and ferulic acid protect the liver from thioacetamide-induced fibrosis in rats via differential expression of miR-21, miR-30 and miR-200 and impact on TGF-β1/Smad3 signaling.

    abstract::This study evaluates the possible protective effects of gallic acid (GaA) and ferulic acid (FeA) against an experimentally induced liver fibrosis by thioacetamide (TAA) in rats. Animals were divided into: Control group, GaA group (20 mg/kg/day, p.o), FeA (20 mg/kg/day, p.o), TAA group (receiving 250 mg/kg twice/week, ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2020.109098

    authors: Hussein RM,Anwar MM,Farghaly HS,Kandeil MA

    更新日期:2020-06-01 00:00:00

  • Dysregulation of UDP-glucuronosyltransferases in CCl4 induced liver injury rats.

    abstract::UDP-glucuronosyltransferases (UGTs) are a family of phase II drug metabolizing enzymes that catalyze glucuronidation of numerous endogenous and exogenous substrates. Carbon tetrachloride (CCl4) is widely used to develop liver injuries mimicking human liver diseases. However, effects of CCl4 on the expression and activ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章

    doi:10.1016/j.cbi.2020.109115

    authors: Xu L,Zheng R,Xie P,Guo Q,Ji H,Li T

    更新日期:2020-07-01 00:00:00