Metabolism of a DDT metabolite via a chloroepoxide.

abstract：:A detailed subfractionation of the non-pregnant porcine corpus luteum (CL) was performed employing differential centrifugation. Marker enzyme assays (i.e., lactate dehydrogenase for the cytosol, NADPH-cytochrome P450 reductase for the endoplasmatic reticulum, catalase (CAT) for peroxisomes, glutamate dehydrogenase for...

journal_title：Chemico-biological interactions

authors： Boström M,Björk K,Nelson BD,DePierre JW

更新日期：2004-01-15 00:00:00

abstract：:Chinese hamster ovary (CHO) cells in vitro were treated with HgCl2 at various stages in the cell cycle and the effects of this chemical on cell survival, DNA replication, and cell division were observed. In terms of survival the early G1 cells were the most sensitive to treatment, followed by late G1 and early S, whil...

journal_title：Chemico-biological interactions

authors： Kasschau MR,Elder J,Meyn RE

更新日期：1977-08-01 00:00:00

abstract：:The trace metals are frequently encountered as mixtures of essential and non-essential elements. Therefore, evaluation of their toxic effects individually does not offer a realistic estimate of their impact on biological processes. We studied effects of a mixture of four essential and toxic metals (Cu, Cd, Fe and Ni) ...

journal_title：Chemico-biological interactions

authors： Pandey S,Parvez S,Ansari RA,Ali M,Kaur M,Hayat F,Ahmad F,Raisuddin S

更新日期：2008-08-11 00:00:00

abstract：:Inflammation and oxidative stress exert important roles in intestinal ischemia-reperfusion injury (IRI). Lycium barbarum polysaccharides (LBPs) have shown effective antioxidative and immunomodulatory functions in different models. The purpose of the present study was to assess the effects and potential mechanisms of L...

journal_title：Chemico-biological interactions

authors： Yang X,Bai H,Cai W,Li J,Zhou Q,Wang Y,Han J,Zhu X,Dong M,Hu D

更新日期：2013-08-25 00:00:00

abstract：:The hydroquinone and catechol like metabolites, NCQ344 and NCQ436 respectively, of the antipsychotic remoxipride have recently been demonstrated to induce apoptosis in myeloperoxidase (MPO)-rich human bone marrow progenitor and HL-60 cells [S.M. McGuinness, R. Johansson, J. Lundstrom, D. Ross, Induction of apoptosis b...

journal_title：Chemico-biological interactions

authors： Inayat-Hussain SH,McGuinness SM,Johansson R,Lundstrom J,Ross D

更新日期：2000-08-15 00:00:00

abstract：:A new analysis of the quantitative structure-activity relationship (QSAR) of the antitumor activity of anilinoacridines against L1210 leukemia in mice and mouse toxicity is reported. QSAR have also been derived for the inhibitory activity of the anilinoacridines with tumor cells and their binding to DNA. These results...

journal_title：Chemico-biological interactions

authors： Gao H,Denny WA,Garg R,Hansch C

更新日期：1998-11-27 00:00:00

abstract：:Male CBA mice were exposed to propene, unlabelled or 14C-labelled, by inhalation, or to 14C-labelled propylene oxide by intraperitoneal injection. 2-Hydroxypropyl adducts to guanine-N-7 in DNA of various organs and to N-terminal valine and histidine-N pi in hemoglobin were measured. The adduct levels observed show tha...

journal_title：Chemico-biological interactions

authors： Svensson K,Olofsson K,Osterman-Golkar S

更新日期：1991-01-01 00:00:00

abstract：:Levels of mixed-function oxidase (MFO) enzymes were measured in adriamycin(ADR)-sensitive murine leukemia P-388 and its ADR-resistant subline P-388/ADR. The subcellular fractions of the resistant cells showed decreased contents of MFO components, cytochrome P-450 and cytochrome b5, in comparison with the identically p...

journal_title：Chemico-biological interactions

authors： Mungikar A,Chitnis M,Gothoskar B

更新日期：1981-04-01 00:00:00

abstract：:Oxcarbazepine, a second generation antiepileptic drug belonging to the family of dibenz[b,f]azepines, is subjected to a rapid and extensive biotransformation. Oxcarbazepine demonstrates a low potential for drug interactions because its biotransformation is mainly mediated by the reduction pathway instead of oxidative ...

journal_title：Chemico-biological interactions

authors： Malátková P,Havlíková L,Wsól V

更新日期：2014-09-05 00:00:00

abstract：:Mode of interaction of mercuric mercury and selenite in rabbit blood was investigated in vitro. After the incubation of rabbit blood with 10(-5) M each of 203HgCl2 and Na2(75)SeO3, the amounts of both 203Hg and 75Se incorporated into erythrocytes were markedly larger than the case where the blood was treated separatel...

journal_title：Chemico-biological interactions

authors： Naganuma A,Imura N

更新日期：1983-03-01 00:00:00

abstract：:The lipopolysaccharide (LPS)-Toll-like receptor 4 (TLR4) signaling pathway in alveolar epithelial cells plays an important role in many pathologic processes such as acute lung injury (ALI). The single immunoglobulin IL-1 receptor-related protein (SIGIRR) is an inhibitor of LPS-TLR4 signaling, but its expression and fu...

journal_title：Chemico-biological interactions

authors： Feng T,Yunfeng N,Jinbo Z,Zhipei Z,Huizhong Z,Li L,Tao J,Yunjie W

更新日期：2010-02-12 00:00:00

abstract：:The in vitro effect of aflatoxins M1, B1 and G1 on oxidative phosphorylation by rat liver mitochondria with succinate as substrate has been studied. All these toxins inhibit the electron transport chain at a 1-10-4 M concentration and the site of inhibition is between cytochrome b and cytochrome c or c1. Aflatoxin M1 ...

journal_title：Chemico-biological interactions

authors： Ramachandra Pai M,Jayanthi Bai N,Venkitasubramanian TA

更新日期：1975-02-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate to 1,3-diphosphoglycerate, one of the precursors for glycolytic ATP biosynthesis. The enzyme contains an active site cysteine thiolate, which is critical for its catalytic function. As part of a conti...

journal_title：Chemico-biological interactions

authors： Rodriguez CE,Fukuto JM,Taguchi K,Froines J,Cho AK

更新日期：2005-06-30 00:00:00

abstract：:Chronic pancreatitis is characterized by pancreatic fibrosis, associated with excessive activation of pancreatic stellate cells (PSCs) and increased expression of transforming growth factor-β1 (TGF-β1). Recently, our studies have shown that autophagy inhibitor could inhibit PSCs activation and reduce collagen secretio...

journal_title：Chemico-biological interactions

authors： Cui LH,Li CX,Zhuo YZ,Yang L,Cui NQ,Zhang SK

更新日期：2019-02-25 00:00:00

abstract：:Boldine is the main alkaloid of Peumus boldus Molina, widely used in the traditional medicine for the treatment of digestive disorders. It is a compound with excellent antioxidant and anti-inflammatory properties already described. Despite the widespread use of P. boldus for digestive disorders treatment, the gastropr...

journal_title：Chemico-biological interactions

authors： Boeing T,Mariano LNB,Dos Santos AC,Tolentino B,Vargas AC,de Souza P,Nesello LAN,da Silva LM

更新日期：2020-08-25 00:00:00

abstract：:Chondroitin sulfate (CS), a highly anionic polymer and the most predominant sulfated glycosaminoglycan in connective tissues, was investigated regarding to its interaction with cationic disinfectants, which are used as antiinfectives in humans. Combinations of cetylpyridiniumchloride (CPC), chlorhexidine (CHex), and p...

journal_title：Chemico-biological interactions

authors： Müller G,Kramer A

更新日期：2000-01-15 00:00:00

abstract：:Toxic medium chain length alkanals, alkenals, and 4-hydroxyalkenals that are generated during lipid peroxidation are potential substrates for aldehyde dehydrogenase (ALDH) isoforms. We have developed transgenic cell lines to examine the potential for either human ALDH1A1 or ALDH3A1 to protect against damage mediated b...

journal_title：Chemico-biological interactions

authors： Townsend AJ,Leone-Kabler S,Haynes RL,Wu Y,Szweda L,Bunting KD

更新日期：2001-01-30 00:00:00

abstract：:Since endogenous glutathione (GSH), the main non-protein intracellular thiol compound, is known to provide protection against reactive radical species, its depletion by diethylmaleate (DEM) was used to assess the role of free radical formation mediated by doxorubicin in DNA damage, cytotoxicity and mutagenicity of the...

journal_title：Chemico-biological interactions

authors： Capranico G,Babudri N,Casciarri G,Dolzani L,Gambetta RA,Longoni E,Pani B,Soranzo C,Zunino F

更新日期：1986-02-01 00:00:00

abstract：:Damage of cell membranes by reactive oxygen species results in the formation of toxic lipid peroxides which may ultimately lead to cell death. Among the best characterized intermediates of oxidative stress are the unsaturated aldehydes 4-hydroxynon-2-enal (4-HNE) and its oxidized counterpart 4-oxonon-2-enal (4-ONE). 4...

journal_title：Chemico-biological interactions

authors： Martin HJ,Maser E

更新日期：2009-03-16 00:00:00

abstract：:The total triterpenes isolated from the fruiting bodies of Ganoderma lucidum was examined for its potential to prevent γ-radiation induced membrane damage in rat liver mitochondria and microsomes. The effects of total triterpenes on γ-radiation-induced DNA strand breaks in pBR 322 plasmid DNA in vitro and human periph...

journal_title：Chemico-biological interactions

authors： Smina TP,Maurya DK,Devasagayam TP,Janardhanan KK

更新日期：2015-05-25 00:00:00

abstract：:The aberrant expression level of SARS-CoV-2 cell receptor gene ACE2 was reported in lung adenocarcinoma (LUAD) comorbidity of COVID-19. However, the association of ACE2 expression levels with immunosuppression and metabolic reprogramming in LUAD remains lacking. We investigated the expression level of ACE2, an associa...

journal_title：Chemico-biological interactions

authors： Uddin MN,Akter R,Li M,Abdelrahman Z

更新日期：2021-02-01 00:00:00

abstract：:The feasibility of an oxygen-independent mechanism of chloroform bioactivation was indicated by the covalent binding to lipid and protein occurring in anaerobic incubations of CHCl3 and microsomes in the presence of NADPH. Under these conditions, the loss of cytochrome P-450 and the inhibition of related monoxygenases...

journal_title：Chemico-biological interactions

authors： Testai E,Vittozzi L

更新日期：1986-09-01 00:00:00

abstract：:Due to increasing energy demand and limited fossil fuels, renewable energy sources have gained in importance. Particulate matter (PM) in general, but also PM from the combustion of wood is known to exert adverse health effects in human. These are often related to specific toxic compounds adsorbed to the PM surface, su...

journal_title：Chemico-biological interactions

authors： Gauggel-Lewandowski S,Heussner AH,Steinberg P,Pieterse B,van der Burg B,Dietrich DR

更新日期：2013-11-25 00:00:00

abstract：:Mitochondrial dysfunction appears to contribute to some of the loss of function accompanying ageing. Mitochondria from aged tissue use oxygen inefficiently impairing ATP synthesis and results in increased oxidant production. A high flux of oxidants not only damages mitochondria, but other important cell biomolecules a...

journal_title：Chemico-biological interactions

authors： Arivazhagan P,Ramanathan K,Panneerselvam C

更新日期：2001-11-28 00:00:00

abstract：:The interactions of benzo(a)pyrene (B(a)P) with the cell surface membrane were studied by measuring B(a)P uptake into intact mammalian cells and by determining B(a)P fluorescence in the presence of isolated cell surface membranes. It was found that 0.19 mu-g B(a)P were taken up by 10-6 Chinese hamster ovary (CHO) cell...

journal_title：Chemico-biological interactions

authors： Brunette DM,Katz M

更新日期：1975-07-01 00:00:00

abstract：:Multiplicity of hepatic microsomal coenzyme A ligases catalyzing acyl-CoA thioester formation is an important factor for consideration in relation to the metabolism of xenobiotic carboxylic acids. In this study the kinetic characteristics of rat hepatic microsomal nafenopin-CoA ligase were studied and compared with th...

journal_title：Chemico-biological interactions

authors： Knights KM,Roberts BJ

更新日期：1994-03-01 00:00:00

abstract：:Aldehyde dehydrogenase 2 (ALDH2) catalyzes oxidation of toxic aldehydes to carboxylic acids. Physiologic levels of Mg(2+) ions influence ALDH2 activity in part by increasing NADH binding affinity. Traditional fluorescence measurements monitor the blue shift of the NADH fluorescence spectrum to study ALDH2-NADH interac...

journal_title：Chemico-biological interactions

authors： Gonnella TP,Leedahl TS,Karlstad JP,Picklo MJ

更新日期：2011-05-30 00:00:00

abstract：:Isolated rat hepatocytes were used to investigate the biochemical mechanisms of toxicity of triethyllead (Et3Pb+), a highly neurotoxic degradation product of the antiknocking petrol additive tetraethyllead. As early as 5 min from the addition of 50 microM Et3Pb+ to hepatocyte suspensions a decrease of mitochondrial me...

journal_title：Chemico-biological interactions

authors： Albano E,Bellomo G,Benedetti A,Carini R,Fulceri R,Gamberucci A,Parola M,Comporti M

更新日期：1994-01-01 00:00:00

abstract：:Several two-electron quinone reductases catalyze the redox cycling of polycyclic aromatic hydrocarbon (PAH) o-quinones. When the carbonyl reductase of human placenta catalyzes the cycling of 9,10-phenanthrenequinone in aqueous phosphate buffer, reactive oxygen species are produced. Superoxide dismutase (SOD) inhibits ...

journal_title：Chemico-biological interactions

authors： Jarabak R,Harvey RG,Jarabak J

更新日期：1998-10-02 00:00:00

abstract：:The objectives of the present work were to study the effects of certain peroxisome proliferators on xenobiotic-metabolizing enzyme activities in the testes of normal and hypothyroid rats, i.e. phenol sulfotransferases (pST), phenol UDP-glucuronosyl transferases (pUDPGT), glutathione transferases (GST), catalase, epoxi...

journal_title：Chemico-biological interactions

authors： Mehrotra K,Morgenstern R,Lundqvist G,Becedas L,Bengtsson Ahlberg M,Georgellis A

更新日期：1997-05-02 00:00:00