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Lack of effect of glutathione depletion on cytotoxicity, mutagenicity and DNA damage produced by doxorubicin in cultured cells.

Abstract：

:Since endogenous glutathione (GSH), the main non-protein intracellular thiol compound, is known to provide protection against reactive radical species, its depletion by diethylmaleate (DEM) was used to assess the role of free radical formation mediated by doxorubicin in DNA damage, cytotoxicity and mutagenicity of the anthracycline. Subtoxic concentrations of DEM that produced up to 75% depletion of GSH did not increase doxorubicin cytotoxicity in a variety of cell lines, including Chinese hamster ovary (CHO) and lung (V-79) cells, LoVo human carcinoma cells and P388 murine leukemia cells. Similarly, the number of doxorubicin-induced DNA single strand breaks in CHO cells and the mutation frequency in V-79 cells were not affected by GSH depletion. The results obtained suggest that mechanisms other than free radical formation are responsible for DNA damage, cytotoxicity and mutagenicity of anthracyclines.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Capranico G,Babudri N,Casciarri G,Dolzani L,Gambetta RA,Longoni E,Pani B,Soranzo C,Zunino F

doi

10.1016/0009-2797(86)90037-2

subject

Has Abstract

pub_date

1986-02-01 00:00:00

pages

189-201

issue

2

eissn

0009-2797

issn

1872-7786

pii

0009-2797(86)90037-2

journal_volume

57

pub_type

杂志文章

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