Abstract:
:Chinese hamster ovary (CHO) cells in vitro were treated with HgCl2 at various stages in the cell cycle and the effects of this chemical on cell survival, DNA replication, and cell division were observed. In terms of survival the early G1 cells were the most sensitive to treatment, followed by late G1 and early S, while mid S and late S-G2 treated cells were the least sensitive. Treatment with HgCl2 also resulted in reduced rates of DNA replication and delays in cell division. The early G1 treated cells showed substantially reduced rates of DNA replication followed by 4--5 h division delay. The early S and late S-G2 treated cells had some reduction in their rates of DNA replication followed by corresponding division delay of 2.5 h in the early S treated cells and 1 h in the late S-G2 treated cells.
journal_name
Chem Biol Interactjournal_title
Chemico-biological interactionsauthors
Kasschau MR,Elder J,Meyn REdoi
10.1016/0009-2797(77)90007-2subject
Has Abstractpub_date
1977-08-01 00:00:00pages
205-15issue
2eissn
0009-2797issn
1872-7786pii
0009-2797(77)90007-2journal_volume
18pub_type
杂志文章abstract::The reaction characteristics of chlorothalonil with glyceraldehyde-3-phosphate dehydrogenase (GPDH), from yeast, (EC 1.2.1.12) were studied in vitro. Enzyme inhibition was related to the amount of [14C]chlorothalonil bound to the protein. Kinetics of enzyme inhibition was non-competitive for the substrate glyceraldehy...
journal_title:Chemico-biological interactions
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journal_title:Chemico-biological interactions
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journal_title:Chemico-biological interactions
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更新日期:2017-10-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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journal_title:Chemico-biological interactions
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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journal_title:Chemico-biological interactions
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/0009-2797(91)90009-v
更新日期:1991-01-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2010.01.042
更新日期:2010-09-06 00:00:00
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journal_title:Chemico-biological interactions
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更新日期:2020-02-25 00:00:00
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journal_title:Chemico-biological interactions
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更新日期:2020-03-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
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journal_title:Chemico-biological interactions
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doi:10.1016/j.cbi.2019.05.016
更新日期:2019-08-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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journal_title:Chemico-biological interactions
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/0009-2797(80)90054-x
更新日期:1980-06-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2004.06.006
更新日期:2004-10-15 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2013.08.016
更新日期:2013-11-25 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2019.04.023
更新日期:2019-07-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/0009-2797(94)03606-9
更新日期:1995-06-30 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2014.10.021
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/j.cbi.2020.108968
更新日期:2020-05-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/0009-2797(87)90044-5
更新日期:1987-01-01 00:00:00
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journal_title:Chemico-biological interactions
pub_type: 杂志文章
doi:10.1016/s0009-2797(01)00274-5
更新日期:2001-12-21 00:00:00