Abstract:
:The current experimental work deals with the immunomodulatory studies on the extract of Withania somnifera (L.) Dunal root powder against benzo(a)pyrene induced lung cancer in male Swiss albino mice. In our previous study, we reported the antioxidant and anticarcinogenic effect of W. somnifera (L.) Dunal along with paclitaxel. Immune dysfunction has been found to be associated with cancer and chemotherapy. Benzo(a)pyrene induced cancer animals were treated with 400mg/kg bodyweight of W. somnifera (L.) Dunal extract for 30 days significantly alters the levels of immunocompetent cells, immune complexes and immunoglobulins. Based on the data, the carcinogen as well as the paclitaxel affects the immune system, the toxic side effects on the immune system is more reversible and more controllable by W. somnifera (L.) Dunal. These results concluded the immunomodulatory activity of W. somnifera (L.) Dunal extract, which is a known immunomodulator in indigenous medicine.
journal_name
Chem Biol Interactjournal_title
Chemico-biological interactionsauthors
Senthilnathan P,Padmavathi R,Banu SM,Sakthisekaran Ddoi
10.1016/j.cbi.2005.11.003subject
Has Abstractpub_date
2006-02-25 00:00:00pages
180-5issue
3eissn
0009-2797issn
1872-7786pii
S0009-2797(05)00392-3journal_volume
159pub_type
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