Benzene, the exposome and future investigations of leukemia etiology.


:Benzene exposure is associated with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and probably lymphoma and childhood leukemia. Biological plausibility for a causal role of benzene in these diseases comes from its toxicity to hematopoietic stem cells (HSC) or progenitor cells, from which all leukemias and related disorders arise. The effect of this toxicity is manifest as lowered blood counts (hematotoxicity), even in individuals occupationally exposed to low levels of benzene. Benzene can induce AML/MDS via several well-characterized pathways associated with these diseases. Through its metabolites, benzene induces multiple alterations that likely contribute to the leukemogenic process, and appears to operate via multiple modes of action. To improve mechanistic understanding and for risk assessment purposes, it may be possible to measure several of the key events in these modes of action in an in vitro model of the bone marrow stem cell niche. Even though benzene is leukemogenic at relatively low occupational levels of exposure, it seems unlikely that it is a major cause of leukemia in the general population exposed to benzene in the ppb range. Other established non-genetic causes of AML, e.g. smoking, ionizing radiation and cancer chemotherapy, also only explain about 20% of AML incidence, leaving ∼80% unexplained. The question arises as to how to find the causes of the majority of de novo AMLs that remain unexplained. We propose that we should attempt to characterize the 'exposome' of human leukemia by using unbiased laboratory-based methods to find the unknown 'environmental' factors that contribute to leukemia etiology.


Chem Biol Interact


Smith MT,Zhang L,McHale CM,Skibola CF,Rappaport SM




Has Abstract


2011-06-30 00:00:00














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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Baldissera MD,Souza CF,De Matos AFIM,Baldisserotto B,da Silva AS,Monteiro SG

    更新日期:2018-12-25 00:00:00

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    abstract::Tumor cells are able to survive and proliferate in spite of their increased oxidative stress. This was taken as a hint for the implication of oxidants/antioxidants in the proliferation of glial-tumor cells. In the present study, an anti-proliferative effect of Naringenin, an antioxidant against cerebrally implanted C6...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Sabarinathan D,Mahalakshmi P,Vanisree AJ

    更新日期:2011-01-15 00:00:00

  • Caspase-dependent and -independent mechanisms in apoptosis induced by hydroquinone and catechol metabolites of remoxipride in HL-60 cells.

    abstract::The hydroquinone and catechol like metabolites, NCQ344 and NCQ436 respectively, of the antipsychotic remoxipride have recently been demonstrated to induce apoptosis in myeloperoxidase (MPO)-rich human bone marrow progenitor and HL-60 cells [S.M. McGuinness, R. Johansson, J. Lundstrom, D. Ross, Induction of apoptosis b...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Inayat-Hussain SH,McGuinness SM,Johansson R,Lundstrom J,Ross D

    更新日期:2000-08-15 00:00:00

  • The kinetics of the alkaline hydrolysis of phosphotriesters in DNA.

    abstract::The degradation in alkali of normal DNA and DNA alkylated with dimethyl sulphate (DMS), N-methyl-N-nitrosourea (MNUA) and N-ethyl-N-nitrosourea (ENUA) has been investigated using analytical ultracentrifugation techniques. For control T7-DNA ( denatured form 12.5 - 10(6) daltons) the rate of degradation at 37 degr...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Shooter KV

    更新日期:1976-05-01 00:00:00

  • In vitro metabolic fate of a novel structural class: evidence for the formation of a reactive intermediate on a benzothiophene moiety.

    abstract::The characterization of the metabolic pathways of new chemical entities with a special emphasis on detecting potentially reactive metabolites is increasingly being performed early in the drug discovery process. In the present study, the preliminary in vitro metabolic routes of a series of novel 2-substituted benzothio...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Evans CA,Fries HE,Ward KW

    更新日期:2005-02-28 00:00:00

  • Androgen and estrogen sulfotransferases of the rat liver: physiological function, molecular cloning, and in vitro expression.

    abstract::Cloning of the androgen and estrogen sulfotransferases has allowed studies on their spatiotemporal regulation and physiological function. These two enzymes appear to be involved in regulating target cell sensitivity for the androgenic and estrogenic steroids. Recombinant androgen sulfotransferase produced in insect Sf...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审


    authors: Chatterjee B,Song CS,Kim JM,Roy AK

    更新日期:1994-06-01 00:00:00

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    abstract::The conditions for alternating current (a.c.) voltammetric DNA determinations have been investigated with respect to its use with alkaline filter elution techniques at low DNA concentrations. In inorganic electrolyte solutions three current peaks can be distinguished: peak I around -1.1 V caused by the reorientation o...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


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  • Methylseleninic acid and sodium selenite induce severe ER stress and subsequent apoptosis through UPR activation in PEL cells.

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Shigemi Z,Manabe K,Hara N,Baba Y,Hosokawa K,Kagawa H,Watanabe T,Fujimuro M

    更新日期:2017-03-25 00:00:00

  • Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease.

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Ryu B,Li Y,Qian ZJ,Kim MM,Kim SK

    更新日期:2009-05-15 00:00:00

  • PTP1B, α-glucosidase, and DPP-IV inhibitory effects for chromene derivatives from the leaves of Smilax china L.

    abstract::Two new flavonoids, bismilachinone (11) and smilachinin (14), were isolated from the leaves of Smilax china L. together with 14 known compounds. Their structures were elucidated using spectroscopic methods. The PTP1B, α-glucosidase, and DPP-IV inhibitory activities of compounds 1-16 were evaluated at the molecular lev...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Zhao BT,Le DD,Nguyen PH,Ali MY,Choi JS,Min BS,Shin HM,Rhee HI,Woo MH

    更新日期:2016-06-25 00:00:00

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Nair CK,Pradhan DS

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    pub_type: 杂志文章


    authors: Betina V,Kuzela S

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    pub_type: 杂志文章


    authors: Fischer B,Boutserin S,Mazon H,Collin S,Branlant G,Gruez A,Talfournier F

    更新日期:2013-02-25 00:00:00

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    pub_type: 杂志文章


    authors: Khames A,Khalaf MM,Gad AM,Abd El-Raouf OM,Kandeil MA

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Arulselvan P,Subramanian SP

    更新日期:2007-01-30 00:00:00

  • Anti-inflammatory effect of thalidomide dithiocarbamate and dithioate analogs.

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Talaat R,El-Sayed W,Agwa HS,Gamal-Eldeen AM,Moawia S,Zahran MA

    更新日期:2015-08-05 00:00:00

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Garner RC,Wright CM

    更新日期:1975-08-01 00:00:00

  • Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK.

    abstract::Chaetocin is a natural product isolated from Chaetomium species that has anti-bacterial and anti-myeloma activities. In this study, we investigated the inhibitory effect of chaetocin on melanogenesis and the underlying mechanisms in B16F10 mouse melanoma cells. In the present study, chaetocin significantly inhibited I...

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    pub_type: 杂志文章


    authors: Bae JS,Han M,Yao C,Chung JH

    更新日期:2016-02-05 00:00:00

  • Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells.

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Wang X,Hayashi S,Umezaki M,Yamamoto T,Kageyama-Yahara N,Kondo T,Kadowaki M

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    pub_type: 杂志文章,评审


    authors: Moon HS,Lee HG,Choi YJ,Kim TG,Cho CS

    更新日期:2007-04-25 00:00:00

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    pub_type: 杂志文章


    authors: Liu Z,Li Z,Chen Z,Li C,Lei L,Wu X,Li Y

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Song N,Zhao Z,Ma X,Sun X,Ma J,Li F,Sun L,Lv J

    更新日期:2017-01-05 00:00:00

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Schiar VP,Dos Santos DB,Paixão MW,Nogueira CW,Rocha JB,Zeni G

    更新日期:2009-01-15 00:00:00

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Amicarelli F,Bonfigli A,Colafarina S,Bucciarelli T,Principato G,Ragnelli AM,Di Ilio C,Miranda M

    更新日期:1998-07-24 00:00:00

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Hoffmann KJ,Streeter AJ,Axworthy DB,Baillie TA

    更新日期:1985-02-01 00:00:00

  • Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells.

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Ma G,Luo W,Lu J,Ma DL,Leung CH,Wang Y,Chen X

    更新日期:2016-06-25 00:00:00

  • Quinone imine-induced Ca2+ release from isolated rat liver mitochondria.

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Weis M,Moore GA,Cotgreave IA,Nelson SD,Moldeus P

    更新日期:1990-01-01 00:00:00

  • The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA.

    abstract::The microsomal metabolism of pentachlorophenol (PCP) was investigated, with special attention to the conversion dependent covalent binding to protein and DNA. The two metabolites detected were tetrachloro-1,2- and tetrachloro-1,4-hydroquinone. Microsomes from isosafrole (ISF)-induced rats were by far the most effectiv...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: van Ommen B,Adang A,Müller F,van Bladeren PJ

    更新日期:1986-10-15 00:00:00

  • Formation, resealing and persistence of DNA breaks produced by 4-demethoxydaunorubicin in P388 leukemia cells.

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Capranico G,Tinelli S,Zunino F

    更新日期:1989-01-01 00:00:00

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    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Mauro M,Crosera M,Bovenzi M,Adami G,Baracchini E,Maina G,Filon FL

    更新日期:2018-09-25 00:00:00