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NOL8, the binding protein for beta-catenin, promoted the growth and migration of prostate cancer cells.

Abstract：

:Overactivation of beta-catenin/TCF signaling in prostate cancer is very common. However, how the beta-catenin/TCF complex is regulated in the nucleus remains largely unknown. In this study, we have shown that NOL8, a binding protein of beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin/TCF signaling. NOL8 is up-regulated in the prostate cancer, and promoted the growth, migration and colony formation of cancer cells. Knocking down the expression of NOL8 inhibited the growth, migration and colony formation of prostate cancer cells. The molecular mechanism study demonstrated that NOL8 promoted the migration and colony formation of cancer cells by activating beta-catenin/TCF signaling. Taken together, this study demonstrated the oncogenic roles of NOL8 in prostate cancer and suggested that NOL8 might be an important therapeutic target for prostate cancer.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Gu S,Hou P,Liu K,Niu X,Wei B,Mao F,Xu Z

doi

10.1016/j.cbi.2018.08.019

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

40-47

eissn

0009-2797

issn

1872-7786

pii

S0009-2797(18)30169-8

journal_volume

294

pub_type

杂志文章

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