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Studies on the reduction of nitroblue tetrazolium chloride mediated through the action of NADH and phenazine methosulphate.

Abstract：

:The general features of the reduction of nitroblue tetrazolium chloride (NBT) by NADH and phenazine methosulphate (PMS) have been studied under aerobic and anaerobic conditions. Under aerobic condition the reduction appears to be mediated through the intermediate formation of the superoxide anion radical O2-.; this reaction is strongly inhibited by superoxide dismutase and by a number of O2-. scavengers such as propyl gallate, (+)-catechin, manganous ions, reduced glutathione and benzoquinone. Cupric ions inhibited the overall reaction by reoxidising reduced PMS. Under anaerobic conditions, superoxide dismutase had only a small inhibitory action and, with the exception of cupric ions, the other substances mentioned above were ineffective as inhibitors. The data presented show that the use of NBT to detect the presence of O2-. is fraught with difficulties due to an equally rapid reduction of NBT by NADH and PMS under anaerobic conditions.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Ponti V,Dianzani MU,Cheeseman K,Slater TF

doi

10.1016/0009-2797(78)90090-x

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

281-91

issue

3

eissn

0009-2797

issn

1872-7786

pii

0009-2797(78)90090-X

journal_volume

23

pub_type

杂志文章

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