A robust approach to IMRT optimization.

abstract：:Many applications of electroporation, especially those utilizing electrofusion and in-vivo electroporation, involve cell environments that include close cell-to-cell proximity and a wide range of target cell size. It is important to understand how this kind of environment may alter optimum electroporation electrical p...

journal_title：Physics in medicine and biology

authors： Gaynor PT,Bodger PS

更新日期：2006-06-21 00:00:00

abstract：:Over the last 50 years, diagnostic imaging has grown from a state of infancy to a high level of maturity. Many new imaging modalities have been developed. However, modern medical imaging includes not only image production but also image processing, computer-aided diagnosis (CAD), image recording and storage, and image...

journal_title：Physics in medicine and biology

authors： Doi K

更新日期：2006-07-07 00:00:00

abstract：:This study investigates the dosimetric impact of using population-based Hounsfield units (HUs) and ICRU-based HUs as a function of the number of tissue segments for bulk density assignment toward MRI-based treatment planning in the abdomen. To avoid potential geometric differences between CT and MR images, CT images r...

journal_title：Physics in medicine and biology

authors： Hsu SH,Zawisza I,O'Grady K,Peng Q,Tomé WA

更新日期：2018-07-24 00:00:00

abstract：:The electron pencil-beam redefinition algorithm (PBRA), which is used to calculate electron beam dose distributions, assumes that the virtual source of each pencil beam is identical to that of the broad beam incident on the patient. In the present work, a virtual source specific for each pencil beam is modelled by inc...

journal_title：Physics in medicine and biology

authors： Boyd RA,Hogstrom KR,White RA,Starkschall G

更新日期：2001-11-01 00:00:00

abstract：:Quality control (QC) data of radiotherapy linear accelerators, collected by Helsinki University Central Hospital between the years 2000 and 2004, were analysed. The goal was to provide information for the evaluation and elaboration of QC of accelerator outputs and to propose a method for QC data analysis. Short- and l...

journal_title：Physics in medicine and biology

authors： Kapanen M,Tenhunen M,Hämäläinen T,Sipilä P,Parkkinen R,Järvinen H

更新日期：2006-07-21 00:00:00

abstract：:Experimental radiobiological investigations of fast neutron beams involve irradiation of thin cell layers. The irradiation of cells is done either in free air or with a material such as graphite, TE plastic or bone-equivalent plastic covering the cells. This paper discusses the computed dose distributions in LET at sh...

journal_title：Physics in medicine and biology

authors： Bhatia DP,Nagarajan PS

更新日期：1979-09-01 00:00:00

abstract：:We have measured the bulk optical properties of healthy female breast tissues in vivo in the parallel plate, transmission geometry. Fifty-two volunteers were measured. Blood volume and blood oxygen saturation were derived from the optical property data using a novel method that employed a priori spectral information t...

journal_title：Physics in medicine and biology

authors： Durduran T,Choe R,Culver JP,Zubkov L,Holboke MJ,Giammarco J,Chance B,Yodh AG

更新日期：2002-08-21 00:00:00

abstract：:Determination of the cardiorespiratory phase of the heart has numerous applications during cardiac imaging. In this article we propose a novel view-angle independent near-real time cardiorespiratory motion gating and coronary sinus (CS) catheter tracking technique for x-ray fluoroscopy images that are used to guide ca...

journal_title：Physics in medicine and biology

authors： Panayiotou M,Rhode KS,King AP,Ma Y,Cooklin M,O'Neill M,Gill J,Rinaldi CA,Housden RJ

更新日期：2015-10-21 00:00:00

abstract：:An inverse radiation treatment planning algorithm for Sensus Healthcare's SculpturaTM electronic brachytherapy system has been designed. The algorithm makes use of simulated annealing to optimize the conformation number of the treatment plan. The highly anisotropic dose distributions produced by the SculpturaTM x-ray ...

journal_title：Physics in medicine and biology

authors： Badali DS,Vainer Y,Ellenor CW,Mitchell CR,Fishman K,Soro N,Price R,Funk T

更新日期：2021-01-11 00:00:00

abstract：:For angiography using synchrotron radiation we measured the absorbed dose distribution in inhomogeneous phantoms with thin LiF:Mg, Cu, P, LiF:Mg, Ti thermoluminescent dosimeters (TLDs) in tissue and lung substitutes, and with Mg2SiO4:Tb TLDs in bone substitute for 33.32 keV monoenergetic photons from synchrotron radia...

journal_title：Physics in medicine and biology

authors： Nariyama N,Namito Y,Ban S,Hirayama H

更新日期：2001-03-01 00:00:00

abstract：:Exploiting the field response of magnetic tracers, magnetic particle imaging (MPI) allows direct, local quantification of the tracer concentration in bulk structures. Here, we investigated the use of characteristic field response functions to spatially resolve the absolute concentration of multiple nanoparticle specie...

journal_title：Physics in medicine and biology

authors： Han SH,Cho E,Lee DK,Cho G,Kim YR,Cho H

更新日期：2014-11-07 00:00:00

abstract：:Shear wave elastography (SWE) is a potential tool to non-invasively assess cardiac muscle stiffness. This study focused on the effect of the orthotropic material properties and mechanical loading on the performance of cardiac SWE, as it is known that these factors contribute to complex 3D anisotropic shear wave propag...

journal_title：Physics in medicine and biology

authors： Caenen A,Pernot M,Peirlinck M,Mertens L,Swillens A,Segers P

更新日期：2018-03-23 00:00:00

abstract：:A step and shoot sequencer was developed that can be integrated into an IMRT optimization algorithm. The method uses non-uniform fluence steps and is adopted to the constraints of an MLC. It consists of a clustering, a smoothing and a segmentation routine. The performance of the algorithm is demonstrated for eight mat...

journal_title：Physics in medicine and biology

authors： Bär W,Alber M,Nüsslin F

更新日期：2001-07-01 00:00:00

abstract：:A quantitative comparison of two full three-dimensional (3D) gel dosimetry techniques was assessed in a clinical setting: radiochromic gel dosimetry with an in-house developed optical laser CT scanner and polymer gel dosimetry with magnetic resonance imaging (MRI). To benchmark both gel dosimeters, they were exposed t...

journal_title：Physics in medicine and biology

authors： Vandecasteele J,De Deene Y

更新日期：2013-09-21 00:00:00

abstract：:The purpose of this work was to validate GATE-based clinical scale absorbed dose calculations in nuclear medicine dosimetry. GATE (version 6.2) and MCNPX (version 2.7.a) were used to derive dosimetric parameters (absorbed fractions, specific absorbed fractions and S-values) for the reference female computational model...

journal_title：Physics in medicine and biology

authors： Villoing D,Marcatili S,Garcia MP,Bardiès M

更新日期：2017-03-07 00:00:00

abstract：:Current dosimetry protocols (AAPM, IAEA, DIN) recommend the use of parallel-plate ionization chambers for the measurement of absorbed dose-to-water in clinical electron beams. For well-guarded plane-parallel chambers, it is assumed that the perturbation correction pQ is unity for all electron energies. In this study, ...

journal_title：Physics in medicine and biology

authors： Zink K,Wulff J

更新日期：2008-03-21 00:00:00

abstract：:Delivering accurate radiation dose to blood specimens during biological irradiations is essential in quantifying damage of ionizing radiation. To estimate dose to blood samples as accurately as possible, pieces of EBT2 model GAFCHROMIC™ film were placed within an approximately 10 mm finely ground rice layer that was u...

journal_title：Physics in medicine and biology

authors： Aldelaijan S,Nobah A,Alsbeih G,Moftah B,Aldahlawi I,Alzahrany A,Tomic N,Devic S

更新日期：2013-05-21 00:00:00

abstract：:Hair loss is a feared side effect of chemotherapy treatment. It may be prevented by cooling the scalp during administration of cytostatics. The supposed mechanism is that by cooling the scalp, both temperature and perfusion are diminished, affecting drug supply and drug uptake in the hair follicle. However, the effect...

journal_title：Physics in medicine and biology

authors： Janssen FE,Van Leeuwen GM,Van Steenhoven AA

更新日期：2005-09-07 00:00:00

abstract：:Injection of gas into the eye, followed by face-down positioning, is a common protocol for the reseating of the retina in posterior and superior retinal tears and breaks. The physical mechanism by which injected gas helps reattach retinal flaps is often ascribed to the 'buoyancy' force of the injected gas bubble. The ...

journal_title：Physics in medicine and biology

authors： Foster WJ,Chou T

更新日期：2004-07-07 00:00:00

abstract：:The probability of a photon (x-ray, gamma-ray, bremsstrahlung, etc) of a given energy E undergoing absorption or scattering when traversing a layer of material Z can be expressed quantitatively in terms of a linear attenuation coefficient mu (cm(-1)). Since mu is dependent on the material's density, rho (g cm(-3)), wh...

journal_title：Physics in medicine and biology

authors： Hubbell JH

更新日期：1999-01-01 00:00:00

abstract：:We comment on a previous article by Zhang and Newhauser (2009 Phys. Med. Biol. 54 1383-95) which presents several approximate ways of computing the water equivalent of an arbitrary degrader. First, we present a simple exact method which depends only on the range-energy relation of water and of the degrader material. S...

journal_title：Physics in medicine and biology

authors： Gottschalk B

更新日期：2010-05-07 00:00:00

abstract：:The dependence of boron-dose enhancer (BDE) characteristics on dose protocol and 10B concentration was evaluated for BNCT using near-threshold 7Li(p,n)7Be direct neutrons. The treatable protocol depth (TPD) was utilized as an evaluation index. MCNP calculations were performed for near-threshold 7Li(p,n)7Be at a proton...

journal_title：Physics in medicine and biology

authors： Tanaka K,Kobayashi T,Bengua G,Nakagawa Y,Endo S,Hoshi M

更新日期：2005-01-07 00:00:00

abstract：:This paper presents a method to obtain the pencil-beam kernels that characterize a megavoltage photon beam generated in a flattening filter free (FFF) linear accelerator (linac) by deconvolution from experimental measurements at different depths. The formalism is applied to perform independent dose calculations in mod...

journal_title：Physics in medicine and biology

authors： Azcona JD,Barbés B,Wang L,Burguete J

更新日期：2016-01-07 00:00:00

abstract：:We find the dose distribution that maximizes the tumour control probability (TCP) for a fixed mean tumour dose per fraction. We consider a heterogeneous tumour volume having a radiation response characterized by the linear quadratic model with heterogeneous radiosensitivity and repopulation rate that may vary in time....

journal_title：Physics in medicine and biology

authors： Levin-Plotnik D,Hamilton RJ

更新日期：2004-02-07 00:00:00

abstract：:Although the calculation of the surface average of the low-frequency current density distribution over a cross-section of 1 cm2 is required by ICNIRP guidelines, no reference averaging algorithm is indicated, neither in the ICNIRP guidelines nor in the Directive 2004/40/EC that is based on them. The lack of a general ...

journal_title：Physics in medicine and biology

authors： Zoppetti N,Andreuccetti D

更新日期：2009-08-07 00:00:00

abstract：:In dynamic renal scintigraphy, the main interest is the radiopharmaceutical redistribution as a function of time. Quality control (QC) of renal procedures often relies on phantom experiments to compare image-based results with the measurement setup. A phantom with a realistic anatomy and time-varying activity distribu...

journal_title：Physics in medicine and biology

authors： Brolin G,Gleisner KS,Ljungberg M

更新日期：2013-05-21 00:00:00

abstract：:In x-ray based imaging of the breast, contrast between fibroglandular (Fg) tissue and adipose (Ad) tissue is a source of anatomic noise. The goal of this work was to validate by simulation and experiment a mathematical framework for modelling the Fg component of anatomic noise in digital mammograpy (DM) and dual-energ...

journal_title：Physics in medicine and biology

authors： Tanguay J,Lalonde R,Bjarnason TA,Yang CJ

更新日期：2019-10-23 00:00:00

abstract：:Several applications in nuclear medicine require absolute activity quantification of single photon emission computed tomography images. Obtaining a repeatable calibration factor that converts voxel values to activity units is essential for these applications. Because source preparation and measurement of the source ac...

journal_title：Physics in medicine and biology

authors： Anizan N,Wang H,Zhou XC,Wahl RL,Frey EC

更新日期：2015-02-07 00:00:00

abstract：:We present an automatic bi-objective parameter-tuning approach for inverse planning methods for high-dose-rate prostate brachytherapy, which aims to overcome the difficult and time-consuming manual parameter tuning that is currently required to obtain patient-specific high-quality treatment plans. We modelled treatmen...

journal_title：Physics in medicine and biology

authors： Maree SC,Bosman PAN,van Wieringen N,Niatsetski Y,Pieters BR,Bel A,Alderliesten T

更新日期：2020-04-02 00:00:00

abstract：:Most tissue characterization methods use RF data originating from backscattering processes in the insonified tissue. Characterization of the tissue of a thin layer (e.g., an artery wall) poses problems because of the small amount of data available. The tissue layer may be so thin that there are no RF data that are not...

journal_title：Physics in medicine and biology

authors： Linssen FM,Hoeks AP,Brands PJ

更新日期：1991-10-01 00:00:00