Characteristics of boron-dose enhancer dependent on dose protocol and 10B concentration for BNCT using near-threshold 7Li(p,n)7Be direct neutrons.

abstract：:Doxorubicin (Dox) is a well-established chemotherapeutic agent, however it has limited efficacy in treating brain malignancies due to the presence of the blood-brain barrier (BBB). Recent preclinical studies have demonstrated that focused ultrasound induced BBB disruption (BBBD) enables efficient delivery of Dox to th...

journal_title：Physics in medicine and biology

authors： Nhan T,Burgess A,Lilge L,Hynynen K

更新日期：2014-10-21 00:00:00

abstract：:The phosphor GdO2S:Tb is widely used in camera-based electronic portal imaging devices (EPIDs). There is considerable interest in the application of EPIDs to dosimetry and the verification of intensity modulated radiation therapy produced by dynamic multileaf collimation (DMLC). This paper presents direct measurement ...

journal_title：Physics in medicine and biology

authors： Glendinning AG,Hunt SG,Bonnett DE

更新日期：2001-02-01 00:00:00

abstract：:Mean glandular dose is the quantity used for dosimetry in mammography and depends on breast-related characteristics, such as thickness and density, and on the x-ray spectrum used for breast imaging. This work aims to present an experimentally-based method to derive polyenergetic normalized glandular dose coefficients ...

journal_title：Physics in medicine and biology

authors： Santos JC,Tomal A,de Barros N,Costa PR

更新日期：2019-05-10 00:00:00

abstract：:Time-of-flight (TOF) positron emission tomography (PET) technology has recently regained popularity in clinical PET studies for improving image quality and lesion detectability. Using TOF information, the spatial location of annihilation events is confined to a number of image voxels along each line of response, there...

journal_title：Physics in medicine and biology

authors： Mehranian A,Kotasidis F,Zaidi H

更新日期：2016-02-07 00:00:00

abstract：:We recently started orthogonal two-port carbon ion therapy for choroidal melanoma with the intent to reduce the incidence of radiation complications that occur with mono-port therapy. Treatment planning techniques involving therapeutic beam characteristics are described here. The vertical (140 MeV/u) and horizontal (1...

journal_title：Physics in medicine and biology

authors： Koyama-Ito H,Kanai T,Minohara S,Tsuji H,Tsujii H

更新日期：2007-09-07 00:00:00

abstract：:Focused ultrasound and microbubbles have been extensively used to generate therapeutic bioeffects. Despite encouraging in vivo results, there remains poor control of the magnitude and spatial distribution of these bioeffects due to the limited ability of conventional pulse shapes and sequences to control cavitation dy...

journal_title：Physics in medicine and biology

authors： Pouliopoulos AN,Bonaccorsi S,Choi JJ

更新日期：2014-11-21 00:00:00

abstract：:Most tissue characterization methods use RF data originating from backscattering processes in the insonified tissue. Characterization of the tissue of a thin layer (e.g., an artery wall) poses problems because of the small amount of data available. The tissue layer may be so thin that there are no RF data that are not...

journal_title：Physics in medicine and biology

authors： Linssen FM,Hoeks AP,Brands PJ

更新日期：1991-10-01 00:00:00

abstract：:Diffraction-enhanced imaging (DEI) is a new x-ray imaging modality that has been shown to enhance contrast between normal and cancerous breast tissues. In this study, diffraction-enhanced imaging in computed tomography (DEI-CT) mode was used to quantitatively characterize the refraction contrasts of the organized stru...

journal_title：Physics in medicine and biology

authors： Kao T,Connor D,Dilmanian FA,Faulconer L,Liu T,Parham C,Pisano ED,Zhong Z

更新日期：2009-05-21 00:00:00

abstract：:Silicon photomultipliers (SiPMs) are widely used in positron emission tomography (PET), however, SiPMs from different vendors vary in their performance characteristics. In addition, the specifications provided by the manufacturers are measured under different operating conditions and using different test setups, makin...

journal_title：Physics in medicine and biology

authors： Du J,Bai X,Cherry SR

更新日期：2019-08-07 00:00:00

abstract：:Speed of sound (SOS) measurements, typically made using 1 MHz broadband pulses, are increasingly used in the clinical diagnosis of bone disorders. Previous in vitro studies indicate that broadband ultrasound pulses are susceptible to distortion in cancellous bone, leading to imprecise arrival time and SOS measurements...

journal_title：Physics in medicine and biology

authors： Pollintine P,Haddaway MJ,Davie MW

更新日期：2000-07-01 00:00:00

abstract：:An iterative Bayesian reconstruction algorithm for limited view angle tomography, or ectomography, based on the three-dimensional total variation (TV) norm has been developed. The TV norm has been described in the literature as a method for reducing noise in two-dimensional images while preserving edges, without intro...

journal_title：Physics in medicine and biology

authors： Persson M,Bone D,Elmqvist H

更新日期：2001-03-01 00:00:00

abstract：:The purpose of this study was to apply a novel method of multiscale echo texture analysis for distinguishing benign (hemangiomas) from malignant (hepatocellular carcinomas (HCCs) and metastases) focal liver lesions in B-mode ultrasound images. In this method, regions of interest (ROIs) extracted from within the lesion...

journal_title：Physics in medicine and biology

authors： Yoshida H,Casalino DD,Keserci B,Coskun A,Ozturk O,Savranlar A

更新日期：2003-11-21 00:00:00

abstract：:The goal of this study was to determine the quantitative accuracy of our OSEM-APDI reconstruction method based on SPECT/CT imaging for Tc-99m, In-111, I-123, and I-131 isotopes. Phantom studies were performed on a SPECT/low-dose multislice CT system (Infinia-Hawkeye-4 slice, GE Healthcare) using clinical acquisition p...

journal_title：Physics in medicine and biology

authors： Shcherbinin S,Celler A,Belhocine T,Vanderwerf R,Driedger A

更新日期：2008-09-07 00:00:00

abstract：:Microbeam radiation therapy (MRT) is a treatment approach in radiation therapy where the treatment field is spatially fractionated into arrays of a few tens of micrometre wide planar beams of unusually high peak doses separated by low dose regions of several hundred micrometre width. In preclinical studies, this treat...

journal_title：Physics in medicine and biology

authors： Debus C,Oelfke U,Bartzsch S

更新日期：2017-10-19 00:00:00

abstract：:Margins are employed in radiotherapy treatment planning to mitigate the dosimetric effects of geometric uncertainties for the clinical target volume (CTV). Unfortunately, whilst the use of margins can increase the probability that sufficient dose is delivered to the CTV, it can also result in delivering high dose of r...

journal_title：Physics in medicine and biology

authors： Tsang HS,Kamerling CP,Ziegenhein P,Nill S,Oelfke U

更新日期：2018-10-29 00:00:00

abstract：:Most solid-state detectors, including 3D dosimeters, show lower signal in the Bragg peak than expected, a process termed quenching. The purpose of this study was to investigate how variation in chemical composition of a recently developed radiochromic, silicone-based 3D dosimeter influences the observed quenching in p...

journal_title：Physics in medicine and biology

authors： Høye EM,Skyt PS,Balling P,Muren LP,Taasti VT,Swakoń J,Mierzwińska G,Rydygier M,Bassler N,Petersen JB

更新日期：2017-02-21 00:00:00

abstract：:Source anisotropy is a very important factor in the brachytherapy quality assurance of high-dose rate (HDR) 192Ir afterloading stepping sources. If anisotropy is not taken into account then doses received by a brachytherapy patient in certain directions can be in error by a clinically significant amount. Experimental ...

journal_title：Physics in medicine and biology

authors： Baltas D,Giannouli S,Garbi A,Diakonos F,Geramani K,Ioannidis GT,Tsalpatouros A,Uzunoglu N,Kolotas C,Zamboglou N

更新日期：1998-06-01 00:00:00

abstract：:Non-invasive evaluation of the Achilles tendon elastic properties may enhance diagnosis of tendon injury and the assessment of recovery treatments. Shear wave elastography has shown to be a powerful tool to estimate tissue mechanical properties. However, its applicability to quantitatively evaluate tendon stiffness is...

journal_title：Physics in medicine and biology

authors： Brum J,Bernal M,Gennisson JL,Tanter M

更新日期：2014-02-07 00:00:00

abstract：:It is well known that the experimental dosimetry of brachytherapy sources presents a challenge. Depending on the particular-dosimeter used, measurements can suffer from poor spatial resolution (ion chambers), lack of 3D information (film) or errors due to the presence of the dosimeter itself distorting the radiation f...

journal_title：Physics in medicine and biology

authors： McJury M,Tapper PD,Cosgrove VP,Murphy PS,Griffin S,Leach MO,Webb S,Oldham M

更新日期：1999-10-01 00:00:00

abstract：:The sulphuric acid used for the preparation of the Fricke dosimeter solution may contain trace impurities that can affect the yield of ferric ions. Two methods, pre-irradiation or oxidation with hydrogen peroxide, have been proposed to reduce the influence of these impurities. Fricke users sometimes omit this treatmen...

journal_title：Physics in medicine and biology

authors： Palm A,Mattsson O

更新日期：2000-09-01 00:00:00

abstract：:In digital breast tomosynthesis (DBT), image characteristics of projection views and reconstructed volume are different and both have the advantage of detecting breast masses, e.g. reconstructed volume mitigates a tissue overlap, while projection views have less reconstruction blur artifacts. In this paper, an improve...

journal_title：Physics in medicine and biology

authors： Kim DH,Kim ST,Ro YM

更新日期：2015-11-21 00:00:00

abstract：:The influence of artefacts due to metal implants on the range of ion beams is investigated, using a geometrically well-defined head and pelvic phantom together with inserts from steel, titanium and tungsten. The ranges along various beam paths including artefacts were calculated from the TPS and compared to known calc...

journal_title：Physics in medicine and biology

authors： Jäkel O,Reiss P

更新日期：2007-02-07 00:00:00

abstract：:In recent years there has been a large amount of research into the potential use of radiation sensitive gels for three-dimensional verification of clinical radiotherapy doses. In this paper we report the use of a MAGIC gel dosimeter (Fong et al 2001 Phys. Med. Biol. 46 3105) for the verification of a specific patient'...

journal_title：Physics in medicine and biology

authors： Trapp JV,Partridge M,Hansen VN,Childs P,Bedford J,Warrington AP,Leach MO,Webb S

更新日期：2004-05-07 00:00:00

abstract：:The signal properties of polycrystalline mercuric iodide (HgI2) film detectors, under irradiation conditions relevant to mammographic, radiographic, fluoroscopic and radiotherapy x-ray imaging, are reported. Each film detector consists of an approximately 230 to approximately 460 microm thick layer of HgI2 (fabricated...

journal_title：Physics in medicine and biology

authors： Su Z,Antonuk LE,El-Mohri Y,Hu L,Du H,Sawant A,Li Y,Wang Y,Yamamoto J,Zhao Q

更新日期：2005-06-21 00:00:00

abstract：:Calculations indicate that an assembly consisting of an antimony-beryllium source at the centre of a 4 cm radius water sphere surrounded by a 1 mm thick shell of boron-10 will emit neutrons with a broad spectrum at intermediate energies. A device based on this design was constructed using a water-filled, boron-carbide...

journal_title：Physics in medicine and biology

authors： Harvey JR,Bending RC

更新日期：1976-01-01 00:00:00

abstract：:Radiotherapy calculations often involve complex geometries such as interfaces between materials of vastly differing atomic number, such as lung, bone and/or air interfaces. Monte Carlo methods have been used to calculate accurately the perturbation effects of the interfaces. However, these methods can be computational...

journal_title：Physics in medicine and biology

authors： Gifford KA,Horton JL,Wareing TA,Failla G,Mourtada F

更新日期：2006-05-07 00:00:00

abstract：:The goal of this study was to assess the impact of set-up uncertainty on compliance with the objectives and constraints of an intensity modulated radiation therapy protocol for early stage cancer of the oropharynx. As the convolution approach to the quantitative study of set-up uncertainties cannot accommodate either ...

journal_title：Physics in medicine and biology

authors： Ploquin N,Song W,Lau H,Dunscombe P

更新日期：2005-08-07 00:00:00

abstract：:Monitoring the spatio-temporal characteristics of microcirculation is crucial for studying the functional activities of biotissue and the mechanism of disease. However, conventional methods used to measure blood flow suffer from limited spatial resolution or the injection of exogenous substances or the need of scannin...

journal_title：Physics in medicine and biology

authors： Cheng H,Luo Q,Liu Q,Lu Q,Gong H,Zeng S

更新日期：2004-04-07 00:00:00

abstract：:For the treatment planning during intensity modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT), beam fluence maps can be first optimized via fluence map optimization (FMO) under the given dose prescriptions and constraints to conformally deliver the radiation dose to the targets while sparin...

journal_title：Physics in medicine and biology

authors： Gao H

更新日期：2016-04-07 00:00:00

abstract：:We propose and evaluate the performance of an improved preclinical positron emission tomography (PET) scanner design, referred to as Polaroid-PET, consisting of a detector equipped with a layer of horizontal Polaroid to filter scintillation photons with vertical polarization. This makes it possible to improve the spat...

journal_title：Physics in medicine and biology

authors： Sanaat A,Ashrafi-Belgabad A,Zaidi H

更新日期：2020-12-02 00:00:00