Abstract：
:In a controlled, nonrandomized, longitudinal cohort study, we studied the efficacy of systemic immunosuppression in treatment of progressive cicatricial pemphigoid affecting the eyes. Twenty-six patients were studied; 18 received systemic immunosuppressive drugs, and eight received conventional therapy. Three patients who received cytotoxic agents withdrew from the study with intolerable gastrointestinal distress. Fourteen of the 15 patients who were immunosuppressed successfully for prolonged periods experienced a cessation of their episodic ocular inflammation and a halting of their progressive conjunctival cicatrization. They maintained vision at least as good as that present when disease activity was brought under control; in two patients vision improved. The one patient who was adequately immunosuppressed and successfully maintained in such a state for two years but who had progressive ocular surface pathology with eventual blindness had concomitant rheumatoid arthritis and severe sicca syndrome. The three patients who withdrew from immunosuppressive therapy and the eight concomitant controls all showed continued episodic conjunctival inflammation and conjunctival cicatrization with development of severe keratopathy and profound visual loss. Complications in this series included alopecia (100%), anemia (78%), gastrointestinal distress (22%), hemorrhagic cystitis (11.1%), and severe leukopenia (5.5%). These results support the notion that abnormal immunoregulatory mechanisms are involved in the progressive disease activity in cicatricial pemphigoid and that systemic immunosuppression may have an appropriate role in the treatment of this disease.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Foster CS,Wilson LA,Ekins MBdoi
10.1016/s0161-6420(82)34791-0subject
Has Abstractpub_date
1982-04-01 00:00:00pages
340-53issue
4eissn
0161-6420issn
1549-4713pii
S0161-6420(82)34791-0journal_volume
89pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract：BACKGROUND/PURPOSE:To assess the potential of a new diagnostic technique called optical coherence tomography for imaging macular disease. Optical coherence tomography is a novel noninvasive, noncontact imaging modality which produces high depth resolution (10 microns) cross-sectional tomographs of ocular tissue. It is ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(95)31032-9
更新日期：1995-02-01 00:00:00
abstract：PURPOSE:The identification of healthy persons more susceptible to dry eye (DED) symptoms developing after surgery remains an unmet need. We performed this study to build a new Ocular Surface Frailty Index (OSFI) and assess its predictive value for DED symptom onset after cataract surgery. DESIGN:Single-center, observa...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2019.12.012
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:To determine whether glaucoma patients with progressive optic disc change have subsequent visual field progression earlier and at a faster rate compared with those without disc change. DESIGN:Prospective, longitudinal, cohort study. PARTICIPANTS AND CONTROLS:Eighty-one patients with open-angle glaucoma. ME...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2009.04.031
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent. DESIGN:Open-label multicenter study of ADA-treated patients with BD uveitis refractory t...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2018.02.020
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:Heightened public awareness about glaucoma may increase the chance of identifying undetected cases. To ascertain determinants of glaucoma awareness, we surveyed a population visiting a general eye clinic. DESIGN:Cross-sectional study. PARTICIPANTS:1197 general eye clinic patients and their companions. METHOD...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(99)00076-7
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVE:To report the first case of gaze-evoked amaurosis secondary to an intraocular foreign body and to highlight the characteristic clinical findings of patients with this symptom. DESIGN:Case report and review of the literature. METHODS:Case review, clinical history, electrophysiologic testing, and follow-up. ...
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0161-6420(00)00433-4
更新日期：2001-01-01 00:00:00
abstract：:A 4-year-old white female presented with leukocoria of the right eye. White punctate lesions were observed posterior to the retrolental membrane, which suggested retinoblastoma of some examiners. A full history, physical examination, ultrasonography, and CT scan failed to rule the diagnosis of retinoblastoma in or out...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(81)34860-x
更新日期：1981-12-01 00:00:00
abstract：PURPOSE:To analyze the success rate of pulsed intravenous (IV) cyclophosphamide (CyP) for noninfectious ocular inflammatory disease and to identify risk factors for failure of therapy. DESIGN:Retrospective, interventional, noncomparative cohort study. PARTICIPANTS:One hundred ten eyes of 65 patients. METHODS:Through...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2013.01.031
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:To characterize the clinicopathologic phenotype as well as the molecular genetic basis of an autosomal dominant form of corneal amyloidosis. DESIGN:Clinicopathologic and molecular genetic study of a family with a form of corneal amyloidosis. PARTICIPANTS:Forty-nine individuals from one family were studied. M...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2003.09.043
更新日期：2004-06-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between intraocular pressure (IOP) measurements obtained by dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) in African Americans and to assess whether these measures were influenced by ocular parameters including corneal thickness, corneal curvature, and axi...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2006.06.065
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:To determine the heritability of nuclear cataract progression and to explore prospectively the effect of dietary micronutrients on the progression of nuclear cataract. DESIGN:Prospective cohort study. PARTICIPANTS:Cross-sectional nuclear cataract and dietary measurements were available for 2054 white female t...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2016.01.036
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVES:To determine the proportion of all Myocilin coding mutations responsible for advanced primary open-angle glaucoma (POAG) in early-age-at-onset individuals and to investigate the prevalence of exon 3 Myocilin mutations in advanced POAG at any age at onset in a large Australasian cohort. DESIGN:Cross-sectiona...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.11.029
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Postoperative recurrence of pterygium occurs in many patients. The authors studied the recurrence rate of pterygium after administration of a single intraoperative dosage of topcial mitomycin C at the completion of pterygium excision. METHODS AND PATIENTS:Eighty-one patients underwent excision of the pteryg...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0161-6420(96)30635-0
更新日期：1996-04-01 00:00:00
abstract：PURPOSE:To evaluate the effect of a hinged lamellar keratotomy on refraction, vision, and corneal topography of postkeratoplasty eyes with high-degree astigmatism. DESIGN:Noncomparative, interventional case series. PARTICIPANTS:A hinged lamellar keratotomy was performed on nine eyes of nine patients at least 9 months...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(01)00702-3
更新日期：2001-10-01 00:00:00
abstract：:Rhabdomyosarcoma is the most common malignant orbital tumor of childhood. It has twice been reported to arise within the globe from the iris. In addition, teratoid medulloepithelioma, a tumor arising from the ciliary epithelium, can contain a rhabdomyoblastic component, often in combination with other heteroplastic el...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(90)32386-2
更新日期：1990-11-01 00:00:00
abstract：:Fluorescein angiography is an application of the physical phenomenon of fluorescence, which is phosphorescence in which the quantum mechanical decay curve is so rapid that it appears instantaneous, and it consequently has no afterglow. Sodium fluorescein is excited by light energy between 465 and 490 nm, and it decays...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(86)33521-8
更新日期：1986-12-01 00:00:00
abstract：:Data from the United States Consumer Product Safety Commission indicate that air-powered guns were responsible for 22,800 injuries treated in emergency rooms during 1981, of which 1255 were eye injuries. From 1970 to 1981, 32 patients have undergone surgical intervention at the Wilmer Eye Institute for airgun-related ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(84)34159-8
更新日期：1984-10-01 00:00:00
abstract：BACKGROUND:It has been recently documented that multiple bilateral pigmented lesions at the level of the retinal pigment epithelium may be an indicator of patients with familial adenomatous polyposis who are prone to develop intestinal cancer, particularly if there is a positive family history of these intestinal disor...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(92)31736-1
更新日期：1992-11-01 00:00:00
abstract：PURPOSE:To investigate when retinal pigment epithelium (RPE) tears occur and their associated treatment patterns and long-term visual outcomes in patients with neovascular age-related macular degeneration (nAMD) during anti-vascular endothelial growth factor (VEGF) treatment. DESIGN:Case-control analysis from a prospe...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2017.08.039
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:Cataract and glaucoma commonly coexist in elderly patients and present complex treatment options. This study investigates the results of simultaneous treatment of both conditions using phacoemulsification with posterior chamber lens implant and mitomycin-augmented trabeculectomy (combined surgery). METHODS:A r...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30571-x
更新日期：1996-07-01 00:00:00
abstract：PURPOSE:To compare the efficacy and safety of fibrin glue and suturing for attaching conjunctival autografts among patients undergoing pterygium excision. DESIGN:Prospective, randomized, interventional case series. PARTICIPANTS:Twenty-two patients undergoing excision of primary pterygium. METHODS:A superior conjunct...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.ophtha.2004.08.028
更新日期：2005-04-01 00:00:00
abstract：:Thirty-three type l diabetics who used continuous subcutaneous infusion of insulin (CSll) and 24 diabetics on conventional treatment (maximum of two injections per day) were studied prospectively with ophthalmologic examinations, fundus photography, fluorescein angiography, and glycosylated hemoglobin (HbA1) determina...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(85)33903-9
更新日期：1985-08-01 00:00:00
abstract：PURPOSE:To characterize the phenotype and investigate the associations of intraretinal crystalline deposits in a large cohort with type 2 idiopathic macular telangiectasia (MacTel). DESIGN:Case-control study. PARTICIPANTS:Patients with and without retinal crystals from the Macular Telangiectasia Project, an internati...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2011.05.022
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To investigate the long-term outcome of keratolimbal allograft (KLAL) for the treatment of severe ocular surface disorders. DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Twenty patients (23 eyes) with severe ocular surface disorders. INTERVENTION:Thirty-three KLAL procedures were performed. ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(02)01081-3
更新日期：2002-07-01 00:00:00
abstract：PURPOSE:To investigate the frequency of sneezing among patients receiving intravenous sedation and periocular local anesthetic for oculoplastic procedures in a single center. To identify potential risk factors involved. DESIGN:Prospective, consecutive, interventional case series in a single tertiary-referral oculoplas...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2009.09.007
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Although the automobile air bag is a safety device used to protect drivers from death and moderate-to-severe injury, recently it also has been reported to be associated with some ophthalmic injuries. The authors have encountered a case in which a normal air bag may have caused a driver's corneal endothelial ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(13)31394-3
更新日期：1993-12-01 00:00:00
abstract：:Comparisons between automated suprathreshold static perimetry and manual kinetic perimetry were performed for 226 eyes with glaucoma or ocular hypertension, and 147 eyes with other optic nerve disease. Both techniques produced similar high detection rates for glaucomatous visual field defects, whereas suprathreshold s...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(79)35399-4
更新日期：1979-07-01 00:00:00
abstract：PURPOSE:To use longitudinal quantitative morphologic and visual acuity (VA) data to investigate the risk of choroidal neovascularization (CNV) event occurrence in eyes with dry age-related macular degeneration (AMD). DESIGN:Prospective observational study. PARTICIPANTS:A total of 513 participants (844 eyes) followed ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.02.048
更新日期：2012-07-01 00:00:00
abstract：PURPOSE:To determine the independent, relative, and combined impact of reduced distance and near vision on the vision-specific quality of life (VS QOL) of adults in Timor-Leste. DESIGN:A population-based cross-sectional eye health survey was conducted in urban and rural areas in Timor-Leste. PARTICIPANTS:Participants...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2010.03.041
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:The aim of the study was to determine whether subconjunctival anesthesia is effective at reducing pain associated with laser retinopexy. DESIGN:This was a single-center, prospective, patient-masked, randomized, controlled trial. PARTICIPANTS:In the primary study group, 65 patients were recruited. Thirty-two p...
journal_title：Ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ophtha.2010.01.036
更新日期：2010-09-01 00:00:00
