Decreased serum tuftsin concentrations in sickle cell disease.

Abstract:

:The serum concentrations of the phagocytosis-stimulating peptide, tuftsin, were determined by radioimmunoassay in 21 patients with sickle cell disease and in 12 healthy controls. The mean serum tuftsin concentration was significantly lower in patient with haemoglobin SS disease (154.3 +/- 35.1 ng/ml; 308.6 +/- 70.2 nmol/l, P < 0.01) and in patients with haemoglobin SC and CC disease (180.9 +/- 42.7 ng/ml; 361.8 +/- 85.4 nmol/l, P < 0.05) than in healthy controls (228.7 +/- 46.7 ng/ml; 457.4 +/- 93.4 nmol/1). Tuftsin deficiency is an indicator of splenic hypofunction and may contribute to the increased susceptibility of patients with sickle cell disease to severe infection.

journal_name

Arch Dis Child

authors

Spirer Z,Weisman Y,Zakuth V,Fridkin M,Bogair N

doi

10.1136/adc.55.7.566

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

566-7

issue

7

eissn

0003-9888

issn

1468-2044

journal_volume

55

pub_type

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