Gastric emptying and intestinal transit of pancreatic enzyme supplements in cystic fibrosis.

Abstract:

OBJECTIVE:To investigate gastric emptying and intestinal transit of pelleted pancreatin in relation to food boluses. METHODS:Dual isotope scintigraphy combined with breath hydrogen sampling was used to track the concurrent gastric emptying and intestinal transit of 111indium labelled microspheres and a 99mtechnetium labelled tin colloid test meal. Twelve pancreatic insufficient cystic fibrosis patients aged 5 to 38 years performed the study. RESULTS:50% gastric emptying times showed patient to patient variation. The mean discrepancy in 50% gastric emptying times between the two labels was > 67 minutes. Mean small bowel transit time for the food bolus was prolonged at 3.6 minutes. A significant correlation was seen between weight standard deviation score and 50% emptying time for pancreatin (r = +0.73). CONCLUSION:Gastric mixing of food and pancreatin may be limited by rapid emptying of microspheres. Patients with high dosage requirements could benefit from changing the pattern of their pancreatin supplementation.

journal_name

Arch Dis Child

authors

Taylor CJ,Hillel PG,Ghosal S,Frier M,Senior S,Tindale WB,Read N

doi

10.1136/adc.80.2.149

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

149-52

issue

2

eissn

0003-9888

issn

1468-2044

journal_volume

80

pub_type

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