Pellagra probably due to pyrazinamide: development during combined chemotherapy of tuberculosis.

Abstract:

:Pellagra secondary to antituberculous chemotherapy can result from isoniazide therapy, as well as from pyrazinamide treatment. Because of the similarity in structural formulas between pyrazinamide, isoniazide, and nicotinamide, the substrate competition is the mechanism most likely involved. The patient was cured by administration of nicotinamide during continued unchanged chemotherapy of her tuberculosis.

journal_name

Int J Dermatol

authors

Jørgensen J

doi

10.1111/j.1365-4362.1983.tb02114.x

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

44-5

issue

1

eissn

0011-9059

issn

1365-4632

journal_volume

22

pub_type

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