当前位置： SCI文献检索 > PHYSICS IN MEDICINE AND BIOLOGY期刊下所有文献 > Population and patient-specific target margins for 4D adaptive radiotherapy to account for intra- and inter-fraction variation in lung tumour position.

Population and patient-specific target margins for 4D adaptive radiotherapy to account for intra- and inter-fraction variation in lung tumour position.

Abstract：

:In this work, five 4D image-guidance strategies (two population, an offline adaptive and two online strategies) were evaluated that compensated for both inter- and intra-fraction variability such as changes to the baseline tumour position and respiratory pattern. None of the strategies required active motion compensation such as gating or tracking; all strategies simulated a free-breathing-based treatment technique. Online kilovoltage fluoroscopy was acquired for eight patients with lung tumours, and used to construct inter- and intra-fraction tumour position variability models. Planning was performed on a mid-ventilation image acquired from a respiration-correlated CT scan. The blurring effect of tumour position variability was included in the dose calculation by convolution. CTV to PTV margins were calculated for variability in the cranio-caudal direction. A population margin of 9.0 +/- 0.7 mm was required to account for setup error and respiration in the study population without the use of image-guidance. The greatest mean margin reduction was introduced by the offline adaptive strategy. A daily online correction strategy produced a small reduction (1.6 mm) in the mean margin from the offline strategy. Adaptively correcting for an inter-fraction change in the respiratory pattern had little effect on margin size due to most patients having only small daily changes in the respiratory pattern. A daily online correction strategy would be useful for patients who exhibit large variations in the daily mean tumour position, while an offline adaptive strategy is more applicable to patients with less variation.

journal_name

Phys Med Biol

journal_title

Physics in medicine and biology

authors

Hugo GD,Yan D,Liang J

doi

10.1088/0031-9155/52/1/017

subject

Has Abstract

pub_date

2007-01-07 00:00:00

pages

257-74

issue

1

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(07)29443-6

journal_volume

52

pub_type

杂志文章

相关文献

PHYSICS IN MEDICINE AND BIOLOGY文献大全
  • Laser speckle imaging of blood flow in microcirculation.

    abstract：:Monitoring the spatio-temporal characteristics of microcirculation is crucial for studying the functional activities of biotissue and the mechanism of disease. However, conventional methods used to measure blood flow suffer from limited spatial resolution or the injection of exogenous substances or the need of scannin...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/49/7/020

    authors： Cheng H,Luo Q,Liu Q,Lu Q,Gong H,Zeng S

    更新日期：2004-04-07 00:00:00

  • Improving source detection and separation in a spatiotemporal Bayesian inference dipole analysis.

    abstract：:Most existing spatiotemporal multi-dipole approaches for MEG/EEG source localization assume that the dipoles are active for the full time range being analysed. If the actual time range of activity of sources is significantly shorter than the time range being analysed, the detectability, localization and time-course de...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/51/10/004

    authors： Jun SC,George JS,Plis SM,Ranken DM,Schmidt DM,Wood CC

    更新日期：2006-05-21 00:00:00

  • Accuracy of quantitative reconstructions in SPECT/CT imaging.

    abstract：:The goal of this study was to determine the quantitative accuracy of our OSEM-APDI reconstruction method based on SPECT/CT imaging for Tc-99m, In-111, I-123, and I-131 isotopes. Phantom studies were performed on a SPECT/low-dose multislice CT system (Infinia-Hawkeye-4 slice, GE Healthcare) using clinical acquisition p...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/53/17/009

    authors： Shcherbinin S,Celler A,Belhocine T,Vanderwerf R,Driedger A

    更新日期：2008-09-07 00:00:00

  • Dose measurements near a non-radioactive gold seed using radiographic film.

    abstract：:The dose distribution near a non-radioactive gold seed under a 6 MV photon beam was measured using radiographic film, water equivalent bolus and solid water slabs. This type of small seed is typically used as a marker in target positional verification using a portal imager for conformal prostate treatment such as inte...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/50/18/N02

    authors： Chow JC,Grigorov GN

    更新日期：2005-09-21 00:00:00

  • Application of the Monte Carlo integration (MCI) method for calculation of the anisotropy of 192Ir brachytherapy sources.

    abstract：:Source anisotropy is a very important factor in the brachytherapy quality assurance of high-dose rate (HDR) 192Ir afterloading stepping sources. If anisotropy is not taken into account then doses received by a brachytherapy patient in certain directions can be in error by a clinically significant amount. Experimental ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/43/6/029

    authors： Baltas D,Giannouli S,Garbi A,Diakonos F,Geramani K,Ioannidis GT,Tsalpatouros A,Uzunoglu N,Kolotas C,Zamboglou N

    更新日期：1998-06-01 00:00:00

  • Postirradiation effects in alanine dosimeter probes of two different suppliers.

    abstract：:The measurand relevant for the dosimetry for radiation therapy is the absorbed dose to water, DW. The Physikalisch-Technische Bundesanstalt (PTB) is establishing a secondary standard for DW for high-energy photon and electron radiation based on electron spin resonance (ESR) of the amino acid alanine. For practical app...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/53/5/006

    authors： Anton M

    更新日期：2008-03-07 00:00:00

  • Temporal backward projection of optoacoustic pressure transients using fourier transform methods.

    abstract：:In medical imaging different techniques have been developed to gain information from inside a tissue. Optoacoustics is a method to generate tomography pictures of tissue using Q-switched laser pulses. Due to thermal and pressure confinement, a short light pulse generates a pressure distribution inside tissue, which mi...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/46/7/309

    authors： Köstli KP,Frenz M,Bebie H,Weber HP

    更新日期：2001-07-01 00:00:00

  • Film dosimetry using a smart device camera: a feasibility study for point dose measurements.

    abstract：:In this work, a methodology for using a smartphone camera, in conjunction with a light-tight box operating in reflective transmission mode, is investigated as a proof of concept for use as a film dosimetry system. An imaging system was designed to allow the camera of a smartphone to be used as a pseudo densitometer. T...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aa8b36

    authors： Aland T,Jhala E,Kairn T,Trapp J

    更新日期：2017-10-03 00:00:00

  • Physical characterization and performance comparison of active- and passive-pixel CMOS detectors for mammography.

    abstract：:We investigated the physical characteristics of two complementary metal oxide semiconductor (CMOS) mammography detectors. The detectors featured 14-bit image acquisition, 50 microm detector element (del) size and an active area of 5 cm x 5 cm. One detector was a passive-pixel sensor (PPS) with signal amplification per...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/54/6/022

    authors： Elbakri IA,McIntosh BJ,Rickey DW

    更新日期：2009-03-21 00:00:00

  • Improved tumour response prediction with equivalent uniform dose in pre-clinical study using direct intratumoural infusion of liposome-encapsulated ¹⁸⁶Re radionuclides.

    abstract：:Crucial to all cancer therapy modalities is a strong correlation between treatment and effect. Predictability of therapy success/failure allows for the optimization of treatment protocol and aids in the decision of whether additional treatment is necessary to prevent tumour progression. This work evaluated the relatio...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/56/17/016

    authors： Hrycushko BA,Ware S,Li S,Bao A

    更新日期：2011-09-07 00:00:00

  • On MEG forward modelling using multipolar expansions.

    abstract：:Magnetoencephalography (MEG) is a non-invasive functional imaging modality based on the measurement of the external magnetic field produced by neural current sources within the brain. The reconstruction of the underlying sources is a severely ill-posed inverse problem typically tackled using either low-dimensional par...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/47/4/301

    authors： Jerbi K,Mosher JC,Baillet S,Leahy RM

    更新日期：2002-02-21 00:00:00

  • Optical studies of vaporization and stability of fluorescently labelled perfluorocarbon droplets.

    abstract：:Droplets of liquid perfluorocarbon (PFC) are under study as the next generation of contrast agents for ultrasound (US). These droplets can be selectively vaporized into echogenic gas bubbles in situ by externally applied US, with numerous applications to diagnosis and therapy. However, little is known about the mechan...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/57/21/7205

    authors： Reznik N,Seo M,Williams R,Bolewska-Pedyczak E,Lee M,Matsuura N,Gariepy J,Foster FS,Burns PN

    更新日期：2012-11-07 00:00:00

  • A potential method for in vivo range verification in proton therapy treatment.

    abstract：:Proton therapy potentially offers excellent dose conformality and reduction in integral dose. The superior dose distribution is, however, much more sensitive to the radiological depth along the beam path than for photon fields. Variations in this depth due to inaccurate planning calculation, setup uncertainty, respira...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/53/5/016

    authors： Lu HM

    更新日期：2008-03-07 00:00:00

  • Comparison of Geant4 multiple Coulomb scattering models with theory for radiotherapy protons.

    abstract：:Usually, Monte Carlo models are validated against experimental data. However, models of multiple Coulomb scattering (MCS) in the Gaussian approximation are exceptional in that we have theories which are probably more accurate than the experiments which have, so far, been done to test them. In problems directly sensiti...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aa6ce3

    authors： Makarova A,Gottschalk B,Sauerwein W

    更新日期：2017-07-06 00:00:00

  • Clinical commissioning of an in vivo range verification system for prostate cancer treatment with anterior and anterior oblique proton beams.

    abstract：:The purpose of this work is the clinical commissioning of a recently developed in vivo range verification system (IRVS) for treatment of prostate cancer by anterior and anterior oblique proton beams. The IRVS is designed to perform a complete workflow for pre-treatment range verification and adjustment. It contains sp...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/61/8/3049

    authors： Hoesl M,Deepak S,Moteabbed M,Jassens G,Orban J,Park YK,Parodi K,Bentefour EH,Lu HM

    更新日期：2016-04-21 00:00:00

  • Dead time correction and counting statistics for positron tomography.

    abstract：:A correction for loss of events due to dead time in dynamic positron emission tomography (PET) is presented. The model employs a paralysing dead time to describe the behaviour of a tomograph over the range of event rates normally encountered in patient studies (up to 200 000 events/s per detector layer). The Donner 28...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/30/5/002

    authors： Mazoyer BM,Roos MS,Huesman RH

    更新日期：1985-05-01 00:00:00

  • Investigation of real tissue water equivalent path lengths using an efficient dose extinction method.

    abstract：:For proton therapy, an accurate conversion of CT HU to relative stopping power (RSP) is essential. Validation of the conversion based on real tissue samples is more direct than the current practice solely based on tissue substitutes and can potentially address variations over the population. Based on a novel dose exti...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aa782c

    authors： Zhang R,Baer E,Jee KW,Sharp GC,Flanz J,Lu HM

    更新日期：2017-06-23 00:00:00

  • Beam angle selection incorporation of anatomical heterogeneities for pencil beam scanning charged-particle therapy.

    abstract：:In charged particle therapy with pencil beam scanning (PBS), localization of the dose in the Bragg peak makes dose distributions sensitive to lateral tissue heterogeneities. The sensitivity of a PBS plan to lateral tissue heterogeneities can be reduced by selecting appropriate beam angles. The purpose of this study is...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/61/24/8664

    authors： Toramatsu C,Inaniwa T

    更新日期：2016-12-21 00:00:00

  • A method to reconstruct intra-fractional liver motion in rotational radiotherapy using linear fiducial markers.

    abstract：:Complex intra-fractional motion and deformation of the liver significantly impacts the accuracy of delivered dose in radiotherapy. It limits margin reduction, dose escalation and normal tissue sparing. A critical component of motion management is to accurately reconstruct tumor motion. In this study, we developed a si...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/ab4c0d

    authors： Chi Y,Shen C,Li B,Zhang Y,Yang M,Folkert M,Jia X

    更新日期：2019-11-21 00:00:00

  • An optimized workflow for the integration of biological information into radiotherapy planning: experiences with T1w DCE-MRI.

    abstract：:Planning of radiotherapy is often difficult due to restrictions on morphological images. New imaging techniques enable the integration of biological information into treatment planning and help to improve the detection of vital and aggressive tumour areas. This might improve clinical outcome. However, nowadays morphol...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/50/17/020

    authors： Neff T,Kiessling F,Brix G,Baudendistel K,Zechmann C,Giesel FL,Bendl R

    更新日期：2005-09-07 00:00:00

  • An integrated platform for image-guided cardiac resynchronization therapy.

    abstract：:Cardiac resynchronization therapy (CRT) is an effective procedure for patients with heart failure but 30% of patients do not respond. This may be due to sub-optimal placement of the left ventricular (LV) lead. It is hypothesized that the use of cardiac anatomy, myocardial scar distribution and dyssynchrony information...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/57/10/2953

    authors： Ma YL,Shetty AK,Duckett S,Etyngier P,Gijsbers G,Bullens R,Schaeffter T,Razavi R,Rinaldi CA,Rhode KS

    更新日期：2012-05-21 00:00:00

  • Controlled E-field gradient coils for MRI.

    abstract：:Peripheral neural stimulation is a major problem in current gradient coil designs. Induced current problems in patients relate directly to gradient strength and modulation frequency. Present designs of gradient coil tend to limit ultra-high-speed imaging methods such as echo-planar imaging (EPI) and echo-volumar imagi...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/53/7/001

    authors： Mansfield P,Haywood B

    更新日期：2008-04-07 00:00:00

  • Quantitative analysis of bony birth canal for periacetabular osteotomy patient by template fitting.

    abstract：:Periacetabular osteotomy (PAO) is a joint preservation procedure for developmental dysplasia of the hip. Such a procedure requires osteotomy of the medial wall of the acetabulum, which may cause the narrow of the bony birth canal and increase the risk of complications during the childbirth process in the future. Using...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/abcb22

    authors： Shao L,Li H,Liu X,Wang Y,Shi L,Ai D,Fan J,Song H,Zhang H,Yang J

    更新日期：2021-01-22 00:00:00

  • A comparison of 60 Hz uniform magnetic and electric induction in the human body.

    abstract：:High-resolution computations of induced fields are used to assess equivalent source levels for human exposure to uniform low-frequency electric and magnetic fields. These results pertain to 60 Hz foot-to-head electric excitation of the body in three positions with respect to a ground plane, and to magnetic excitation ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/42/12/001

    authors： Dawson TW,Caputa K,Stuchly MA

    更新日期：1997-12-01 00:00:00

  • Image-based view-angle independent cardiorespiratory motion gating and coronary sinus catheter tracking for x-ray-guided cardiac electrophysiology procedures.

    abstract：:Determination of the cardiorespiratory phase of the heart has numerous applications during cardiac imaging. In this article we propose a novel view-angle independent near-real time cardiorespiratory motion gating and coronary sinus (CS) catheter tracking technique for x-ray fluoroscopy images that are used to guide ca...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/60/20/8087

    authors： Panayiotou M,Rhode KS,King AP,Ma Y,Cooklin M,O'Neill M,Gill J,Rinaldi CA,Housden RJ

    更新日期：2015-10-21 00:00:00

  • Amplitude-based data selection for optimal retrospective reconstruction in micro-SPECT.

    abstract：:Respiratory motion can blur the tomographic reconstruction of positron emission tomography or single-photon emission computed tomography (SPECT) images, which subsequently impair quantitative measurements, e.g. in the upper abdomen area. Respiratory signal phase-based gated reconstruction addresses this problem, but d...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/58/8/2657

    authors： Breuilly M,Malandain G,Guglielmi J,Marsault R,Pourcher T,Franken PR,Darcourt J

    更新日期：2013-04-21 00:00:00

  • Inverse treatment planning using volume-based objective functions.

    abstract：:The results of optimization of inverse treatment plans depend on a choice of the objective function. Even when the optimal solution for a given cost function can be obtained, a better solution may exist for a given clinical scenario and it could be obtained with a revised objective function. In the approach presented ...

    journal_title：Physics in medicine and biology

    pub_type： 临床试验,杂志文章

    doi：10.1088/0031-9155/49/12/003

    authors： Bednarz G,Michalski D,Anne PR,Valicenti RK

    更新日期：2004-06-21 00:00:00

  • Substituting gelatine with Pluronic F-127 matrix in 3D polymer gel dosimeters can improve nuclear magnetic resonance, thermal and optical properties.

    abstract：:This work discusses the substitution of a gelatine physical gel matrix with a matrix made of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic F-127) in five 3D radiotherapy polymer gel dosimeters: MAGAT, PAGAT, NIPAM, VIPARnd (VIP) and VIPARCT (VIC). The current research outcomes s...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aad9d5

    authors： Jaszczak M,Wach R,Maras P,Dudek M,Kozicki M

    更新日期：2018-09-06 00:00:00

  • Single-shot K-edge subtraction x-ray discrete computed tomography with a polychromatic source and the Pixie-III detector.

    abstract：:K-edge subtraction (KES) imaging is a technique able to map a specific element such as e.g. a contrast agent within the tissues, by exploiting the sharp rise of its absorption coefficient at the K-edge energy. Whereas mainly explored at synchrotron radiation sources, the energy discrimination properties of modern x-ra...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/ab7105

    authors： Brun F,Di Trapani V,Albers J,Sacco P,Dreossi D,Brombal L,Rigon L,Longo R,Mittone A,Dullin C,Bravin A,Delogu P

    更新日期：2020-03-06 00:00:00

  • Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo.

    abstract：:The purpose of this work was to create a computational platform for studying motion in intensity modulated radiotherapy (IMRT). Specifically, the non-uniform rational B-spline (NURB) cardiac and torso (NCAT) phantom was modified for use in a four-dimensional Monte Carlo (4D-MC) simulation system to investigate the eff...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/55/5/014

    authors： McGurk R,Seco J,Riboldi M,Wolfgang J,Segars P,Paganetti H

    更新日期：2010-03-07 00:00:00