Single-shot K-edge subtraction x-ray discrete computed tomography with a polychromatic source and the Pixie-III detector.

Abstract:

:K-edge subtraction (KES) imaging is a technique able to map a specific element such as e.g. a contrast agent within the tissues, by exploiting the sharp rise of its absorption coefficient at the K-edge energy. Whereas mainly explored at synchrotron radiation sources, the energy discrimination properties of modern x-ray photon counting detectors (XPCDs) pave the way for an implementation of single-shot KES imaging with conventional polychromatic sources. In this work we present an x-ray CT imaging system based on the innovative Pixie-III detector and discrete reconstruction. The results reported here show that a reliable automatic localization of Barium (above a certain concentration) is possible with a few dozens of tomographic projections for a volume having an axial slice of 512 [Formula: see text] 512 pixels. The final application is a routine high-fidelity 3D mapping of a specific element ready for further morphological quantification by means of x-ray CT with potential promising applications in vivo.

journal_name

Phys Med Biol

authors

Brun F,Di Trapani V,Albers J,Sacco P,Dreossi D,Brombal L,Rigon L,Longo R,Mittone A,Dullin C,Bravin A,Delogu P

doi

10.1088/1361-6560/ab7105

subject

Has Abstract

pub_date

2020-03-06 00:00:00

pages

055016

issue

5

eissn

0031-9155

issn

1361-6560

journal_volume

65

pub_type

杂志文章
  • Mathematical modelling of the human cardiovascular system in the presence of stenosis.

    abstract::This paper reports a theoretical study on the distribution of blood flow in the human cardiovascular system when one or more blood vessels are affected by stenosis. The analysis employs a mathematical model of the entire system based on the finite element method. The arterial-venous network is represented by a large n...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/38/3/004

    authors: Sud VK,Srinivasan RS,Charles JB,Bungo MW

    更新日期:1993-03-01 00:00:00

  • The dosimetric impact of dental implants on head-and-neck volumetric modulated arc therapy.

    abstract::This work aims to investigate the dosimetric impact of dental implants on volumetric modulated arc therapy (VMAT) for head-and-neck patients and to evaluate the effectiveness of using the material's electron-density ratio for the correction. An in-house Monte Carlo (MC) code was utilized for the dose calculation to ac...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/4/1027

    authors: Lin MH,Li J,Price RA Jr,Wang L,Lee CC,Ma CM

    更新日期:2013-02-21 00:00:00

  • Computational dosimetry in embryos exposed to electromagnetic plane waves over the frequency range of 10 MHz-1.5 GHz.

    abstract::This paper presents calculated specific absorption rate (SAR) dosimetry in 4 and 8 week Japanese pregnant-woman models exposed to plane waves over the frequency range of 10 MHz-1.5 GHz. Two types of 2 mm spatial-resolution pregnant-woman models comprised a woman model, which is similar to the average-sized Japanese ad...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/1/N01

    authors: Kawai H,Nagaoka T,Watanabe S,Saito K,Takahashi M,Ito K

    更新日期:2010-01-07 00:00:00

  • Towards abdominal MRI-based treatment planning using population-based Hounsfield units for bulk density assignment.

    abstract::This study investigates the dosimetric impact of using population-based Hounsfield units (HUs) and ICRU-based HUs as a function of the number of tissue segments for bulk density assignment toward MRI-based treatment planning in the abdomen. To avoid potential geometric differences between CT and MR images, CT images r...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aacfb1

    authors: Hsu SH,Zawisza I,O'Grady K,Peng Q,Tomé WA

    更新日期:2018-07-24 00:00:00

  • Infrared and visible thermoluminescence signals of Tm-doped CaF2 measured by a semiconductor photodiode.

    abstract::A silicon semiconductor photodiode was used to measure the TL-signal of TLD-300 (CaF2:Tm) detectors irradiated with 60Co gamma rays and 226Ra alpha particles. The applied dose values varied from 0.12 to 14.3 Gy for gamma rays and from about 50 to 300 Gy for alpha particles. Because of the infrared sensitivity of the p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/33/12/006

    authors: Meissner P,Jacob M,Rassow J

    更新日期:1988-12-01 00:00:00

  • Reduction of scatter in breast CT yields improved microcalcification visibility.

    abstract::The inadequate visibility of microcalcifications-small calcium deposits that cue radiologists to early stages of cancer-is a major limitation in current designs of dedicated breast computed tomography (bCT). This limitation has previously been attributed to the constituent components, spatial resolution, and utilized ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abae07

    authors: Ghazi P

    更新日期:2020-12-04 00:00:00

  • Site-specific volumetric analysis of lung tumour motion.

    abstract::The treatment of lung cancer with radiation therapy is hindered by respiratory motion. Real-time adjustments to compensate for this motion are hampered by mechanical system latencies and imaging-rate restrictions. To better understand tumour motion behaviour for adaptive image-guided radiation therapy of lung cancer, ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/12/005

    authors: Pepin EW,Wu H,Sandison GA,Langer M,Shirato H

    更新日期:2010-06-21 00:00:00

  • Dosimetric characterization of a new miniature multileaf collimator.

    abstract::The dosimetrical characteristics of a new miniature multileaf collimator (ModuLeaf MLC, MRC Systems GmbH, Heidelberg, Germany) attached to the accessory holder of a Siemens accelerator with 6 MV x-rays (PRIMUS, Siemens OCS, Concord, California, USA) have been investigated. In particular, those parameters which are imp...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/12/402

    authors: Hartmann GH,Föhlisch F

    更新日期:2002-06-21 00:00:00

  • Factorial phase imaging: a new concept in the analysis of first-pass cardiac studies.

    abstract::A method is described which offers an alternative to conventional Fourier phase/amplitude imaging for analysing representative LV cycles obtained from first-pass cardiac studies. The method involves applying factor analysis to the data and producing functional images of the first two factor loadings after polar transf...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/27/10/007

    authors: Houston AS,Elliott AT,Stone DL

    更新日期:1982-10-01 00:00:00

  • Investigating the effect of longitudinal micro-CT imaging on tumour growth in mice.

    abstract::The aim of this study is to determine the impact of longitudinal micro-CT imaging on the growth of B16F1 tumours in C57BL/6 mice. Sixty mice received 2 × 10(5) B16F1 cells subcutaneously in the hind flank and were divided into control (no scan), 'low-dose' (80 kVp, 70 mA, 8 s, 0.07 Gy), 'medium-dose' (80 kVp, 50 mA, 3...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/2/002

    authors: Foster WK,Ford NL

    更新日期:2011-01-21 00:00:00

  • Dynamic beam modulation by using a single computer-controlled absorber.

    abstract::The authors have developed an apparatus able to generate ID intensity-modulated beams, using only one moving absorber within the irradiation field. A procedure for deriving optimized absorber-speed profiles in order to produce the desired fluence/dose profiles has been suggested. Experimental tests show that the syste...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/40/2/002

    authors: Fiorino C,Lev A,Fusca M,Cattaneo GM,Rudello F,Calandrino R

    更新日期:1995-02-01 00:00:00

  • Effect of microscopic modeling of skin in electrical and thermal analysis of transcranial direct current stimulation.

    abstract::Transcranial direct current stimulation (tDCS) is a neuromodulation scheme where a small current is delivered to the brain via two electrodes attached to the scalp. The electrode design is an important topic, not only as regards efficacy, but also from a safety perspective, as tDCS may be related to skin lesions that ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/61/24/8825

    authors: Gomez-Tames J,Sugiyama Y,Laakso I,Tanaka S,Koyama S,Sadato N,Hirata A

    更新日期:2016-12-21 00:00:00

  • Scatter correction of cone-beam CT using a deep residual convolution neural network (DRCNN).

    abstract::Scatter correction is an essential technique to improve the image quality of cone-beam CT (CBCT). Although different scatter correction methods have been proposed in the literature, a standard solution is still being studied due to the limitations including accuracy, computation efficiency and generalization. In this ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab23a6

    authors: Jiang Y,Yang C,Yang P,Hu X,Luo C,Xue Y,Xu L,Hu X,Zhang L,Wang J,Sheng K,Niu T

    更新日期:2019-07-11 00:00:00

  • A new column-generation-based algorithm for VMAT treatment plan optimization.

    abstract::We study the treatment plan optimization problem for volumetric modulated arc therapy (VMAT). We propose a new column-generation-based algorithm that takes into account bounds on the gantry speed and dose rate, as well as an upper bound on the rate of change of the gantry speed, in addition to MLC constraints. The alg...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/14/4569

    authors: Peng F,Jia X,Gu X,Epelman MA,Romeijn HE,Jiang SB

    更新日期:2012-07-21 00:00:00

  • Beam angle selection incorporation of anatomical heterogeneities for pencil beam scanning charged-particle therapy.

    abstract::In charged particle therapy with pencil beam scanning (PBS), localization of the dose in the Bragg peak makes dose distributions sensitive to lateral tissue heterogeneities. The sensitivity of a PBS plan to lateral tissue heterogeneities can be reduced by selecting appropriate beam angles. The purpose of this study is...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/61/24/8664

    authors: Toramatsu C,Inaniwa T

    更新日期:2016-12-21 00:00:00

  • Accurate Monte Carlo calculations of the combined attenuation and build-up factors, for energies (20-1500 keV) and distances (0-10 cm) relevant in brachytherapy.

    abstract::The combined build-up and attenuation factor, B exp (-mu r), of point isotropic photon sources in a water medium has been calculated using the Monte Carlo method, for energies (20-1500 keV) and distances (1-10 cm) relevant in brachytherapy. For the transport of photons and electrons, up-to-date and self-consistent tot...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/36/6/005

    authors: Angelopoulos A,Perris A,Sakellariou K,Sakelliou L,Sarigiannis K,Zarris G

    更新日期:1991-06-01 00:00:00

  • Numerical study of oxygen transport in a carotid bifurcation.

    abstract::This study investigates the oxygen mass transport in the region around the human carotid bifurcation, particularly addressing the effects of bifurcation geometry and pulsatile blood flow on the oxygen transport between the blood flow and artery wall tissue, coupled with the metabolic oxygen consumption and oxygen diff...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/14/004

    authors: Tada S

    更新日期:2010-07-21 00:00:00

  • Application of an M-line-based backprojected filtration algorithm to triple-cone-beam helical CT.

    abstract::To increase the scanning speed of cone-beam CT, a scanning configuration with three pairs of x-ray sources and panel detectors was proposed. In this paper, we apply the M-line-based backprojected filtration algorithm to this scanning configuration and propose a fast implementation for this algorithm. Compared with exi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/23/009

    authors: Zhao Y,Zhu Y,Zhang P

    更新日期:2010-12-07 00:00:00

  • Prediction of positron emitter distributions for range monitoring in carbon ion therapy: an analytical approach.

    abstract::Range verification is one of the most relevant tasks in ion beam therapy. In the case of carbon ion therapy, positron emission tomography (PET) is the most widely used method for this purpose, which images the [Formula: see text]-activation following nuclear interactions of the ions with the tissue nuclei. Since the p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab17f9

    authors: Hofmann T,Fochi A,Parodi K,Pinto M

    更新日期:2019-05-21 00:00:00

  • Symmetries of the 2D magnetic particle imaging system matrix.

    abstract::In magnetic particle imaging (MPI), the relation between the particle distribution and the measurement signal can be described by a linear system of equations. For 1D imaging, it can be shown that the system matrix can be expressed as a product of a convolution matrix and a Chebyshev transformation matrix. For multidi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/10/4033

    authors: Weber A,Knopp T

    更新日期:2015-05-21 00:00:00

  • Radiobiological aspects of supralinear photographic emulsions.

    abstract::Nuclear emulsions of the Ilford K series, exposed to X-rays from 15 to 150 kVp and systematically underdeveloped, exhibit supralinear blackness--exposure curves ranging from 1- to 4-hit in character, and whose shape is the same at all excitation voltages. Processing can be so adjusted that the curve shape is well repr...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/23/6/007

    authors: Katz R,Pennington EC

    更新日期:1978-11-01 00:00:00

  • Effects of bone- and air-tissue inhomogeneities on the dose distributions of the Leksell Gamma Knife calculated with PENELOPE.

    abstract::Monte Carlo simulation with PENELOPE (version 2003) is applied to calculate Leksell Gamma Knife dose distributions for heterogeneous phantoms. The usual spherical water phantom is modified with a spherical bone shell simulating the skull and an air-filled cube simulating the frontal or maxillary sinuses. Different sim...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/23/018

    authors: Al-Dweri FM,Rojas EL,Lallena AM

    更新日期:2005-12-07 00:00:00

  • High resolution bone mineral densitometry with a gamma camera.

    abstract::A technique is described by which the regional distribution of bone mineral can be determined in bone samples from small animals. The technique employs an Anger camera interfaced to a medical computer. High resolution (less than 1 mm) imaging is possible by producing magnified images of the bone samples. Regional dens...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/29/1/003

    authors: LeBlanc A,Evans H,Jhingran S,Johnson P

    更新日期:1984-01-01 00:00:00

  • Leakage of the Siemens 160 MLC multileaf collimator on a dual energy linear accelerator.

    abstract::Multileaf collimators (MLCs) have been in clinical use for many years and meanwhile are commonly used to deliver intensity-modulated radiotherapy (IMRT) beams. For this purpose it is important to know their dosimetric properties precisely, one of them being inter- and intraleaf leakage. The Siemens 160 MLC features a ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/2/N02

    authors: Klüter S,Sroka-Perez G,Schubert K,Debus J

    更新日期:2011-01-21 00:00:00

  • Energy and spatial distribution of multiple order Compton scatter in SPECT: a Monte Carlo investigation.

    abstract::Energy and spatial projection distributions were simulated for gamma camera imaging of multiple order Compton scattered photons. SPECT imaging of a line source of radioactivity located in a water filled cylindrical phantom was modelled using Monte Carlo techniques. Photon trajectories were followed from emission to de...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/29/10/005

    authors: Floyd CE,Jaszczak RJ,Harris CC,Coleman RE

    更新日期:1984-10-01 00:00:00

  • Photoluminescent thermometry based on europium-activated calcium sulphide.

    abstract::A photoluminescent thermometer, based on the transient emission response of a europium-activated calcium sulphide phosphor, is described in detail. This optical thermometry system has special advantages for temperature measurements in microwave and RF fields and potential application in electromagnetically induced cli...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/27/1/011

    authors: Samulski TV,Chopping PT,Haas B

    更新日期:1982-01-01 00:00:00

  • Additional factors for the estimation of mean glandular breast dose using the UK mammography dosimetry protocol.

    abstract::The UK and European protocols for mammographic dosimetry use conversion factors that relate incident air kerma to the mean glandular dose (MGD) within the breast. The conversion factors currently used were obtained by computer simulation of a model breast with a composition of 50% adipose and 50% glandular tissues by ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/11/308

    authors: Dance DR,Skinner CL,Young KC,Beckett JR,Kotre CJ

    更新日期:2000-11-01 00:00:00

  • Towards using a focussed phased array of millimetre length scale elements for ultrasound imaging.

    abstract::Sparse phased array ultrasound transducers with millimetre length scale elements have previously been proposed for generating hyperthermia but not for imaging. Numerical simulation with a pseudospectral solver was used to investigate: (a) how the position of the maximum pressure in the focal region changed with elemen...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aace07

    authors: Wilson AJ

    更新日期:2018-07-16 00:00:00

  • The GSF family of voxel phantoms.

    abstract::Voxel phantoms are human models based on computed tomographic or magnetic resonance images obtained from high-resolution scans of a single individual. They consist of a huge number of volume elements (voxels) and are at the moment the most precise representation of the human anatomy. The purpose of this paper is to in...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1088/0031-9155/47/1/307

    authors: Petoussi-Henss N,Zanki M,Fill U,Regulla D

    更新日期:2002-01-07 00:00:00

  • Comparative study of a low-Z cone-beam computed tomography system.

    abstract::Computed tomography images have been acquired using an experimental (low atomic number (Z) insert) megavoltage cone-beam imaging system. These images have been compared with standard megavoltage and kilovoltage imaging systems. The experimental system requires a simple modification to the 4 MeV electron beam from an E...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/14/014

    authors: Roberts DA,Hansen VN,Thompson MG,Poludniowski G,Niven A,Seco J,Evans PM

    更新日期:2011-07-21 00:00:00