Abstract:
:Multilaminated controlled release devices were formed through photopolymerization techniques to produce hydrogels with spatially varying solute loadings and network structures composed of poly(hydroxyl ethyl methacrylate) (PHEMA) and poly(ethylene glycol) (PEG). Using low molecular weight fluorescent dyes as model drugs, the distribution profiles were characterized non-invasively in pseudo-real-time with confocal laser scanning microscopy (CLSM) during release studies. For comparison, theoretical modeling based on Fickian diffusion theory was performed in conjunction with experimental work to identify any deviations from expected behavior and to guide in the development of future devices. In multilaminates composed of only PHEMA, the evolution of dye distribution during release and cumulative release profiles agreed well with theoretically predicted data, indicating continuity of diffusion and insignificant interfacial hindrance between layers. However, in devices composed of alternating layers of PHEMA and PEG, differences from predicted behavior were experimentally observed in both concentration profiles and release rates, suggesting interfacial obstruction of diffusion, possibly due to the formation of interpenetrating networks. Finally, the simultaneous release of two dyes at different rates from a PEG/PHEMA multilaminate was monitored to demonstrate the usefulness of CLSM in understanding the complex temporal changes in solute distributions in gel devices.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Watkins AW,Southard SL,Anseth KSdoi
10.1016/j.actbio.2006.11.006subject
Has Abstractpub_date
2007-07-01 00:00:00pages
439-48issue
4eissn
1742-7061issn
1878-7568pii
S1742-7061(06)00153-Xjournal_volume
3pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.actbio.2018.03.058
更新日期:2018-06-01 00:00:00
abstract:UNLABELLED:A novel kind of monodisperse mesoporous manganese silicate coated silica nanoparticle (MMSSN) as a highly efficient T1-weighted MRI contrast agent (CA) and drug carrier for cancer diagnosis and chemotherapy has been constructed by a modified "SiO2 sacrifice and in situ silicate growth" approach under a relat...
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pub_type: 杂志文章
doi:10.1016/j.actbio.2015.11.036
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2010.12.012
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2007.08.013
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
abstract::Sr and CO3 co-substituted hydroxyapatite (SrCHA) nanopowder was synthesized by neutralization. The powder was characterized. The improved solubility in Hanks' balanced solution of SrCHA granules (400-600 microm of dimensional range), potentially usable as bone filler, was assessed and compared with that of an analogou...
journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2007.10.010
更新日期:2008-05-01 00:00:00
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doi:10.1016/j.actbio.2011.12.008
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2019.02.008
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2011.12.037
更新日期:2012-07-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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