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Novel soybean/gelatine-based bioactive and injectable hydroxyapatite foam: material properties and cell response.

Abstract：

:Despite their known osteoconductivity, clinical use of calcium phosphate cements is limited both by their relatively slow rate of resorption and by rheological properties incompatible with injectability. Bone in-growth and material resorption have been improved by the development of porous calcium phosphate cements. However, injectable formulations have so far only been obtained through the addition of relatively toxic surfactants. The present work describes the response of osteoblasts to a novel injectable foamed bone cement based on a composite formulation including the bioactive foaming agents soybean and gelatine. The foaming properties of both defatted soybean and gelatine gels were exploited to develop a self-hardening soy/gelatine/hydroxyapatite composite foam able to retain porosity upon injection. After setting, the foamed paste produced a calcium-deficient hydroxyapatite scaffold, showing good injectability and cohesion as well as interconnected porosity after injection. The intrinsic bioactivity of soybean and gelatine was shown to favour osteoblast adhesion and growth. These findings suggest that injectable, porous and bioactive calcium phosphate cements can be produced for bone regeneration through minimally invasive surgery.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Perut F,Montufar EB,Ciapetti G,Santin M,Salvage J,Traykova T,Planell JA,Ginebra MP,Baldini N

doi

10.1016/j.actbio.2010.12.012

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

1780-7

issue

4

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(10)00563-5

journal_volume

7

pub_type

杂志文章

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