Abstract:
:Vascular damage develops with diverging severity during and after percutaneous coronary intervention with stent placement and is the prevailing stimulus for in-stent restenosis. Previous work has failed to link mechanical data obtained in a realistic in vivo or in vitro environment with data collected during imaging processes. We investigated whether specimens of porcine right coronary arteries soften when indented with a stent strut shaped structure, and if the softening results from damage mechanisms inside the fibrillar collagen structure. To simulate the multiaxial loading scenario of a stented coronary artery, we developed the testing device 'LAESIO' that can measure differences in the stress-stretch behavior of the arterial wall before and after the indentation of a strut-like stamp. The testing protocol was optimized according to preliminary experiments, more specifically equilibrium and relaxation tests. After chemical fixation of the specimens and subsequent tissue clearing, we performed three-dimensional surface and second-harmonic generation scans on the deformed specimens. We analyzed and correlated the mechanical response with structural parameters of high-affected tissue located next to the stamp indentation and low-affected tissue beyond the injured area. The results reveal that damage mechanisms, like tissue compression as well as softening, fiber dispersion, and the lesion extent, are direction-dependent, and the severity of them is linked to the strut orientation, indentation pressure, and position. The findings highlight the need for further investigations by applying the proposed methods to human coronary arteries. Additional data and insights might help to incorporate the observed damage mechanisms into material models for finite element analyses to perform more accurate simulations of stent-implantations.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Geith MA,Nothdurfter L,Heiml M,Agrafiotis E,Gruber M,Sommer G,Schratzenstaller TG,Holzapfel GAdoi
10.1016/j.actbio.2020.08.016subject
Has Abstractpub_date
2020-10-15 00:00:00pages
285-301eissn
1742-7061issn
1878-7568pii
S1742-7061(20)30476-1journal_volume
116pub_type
杂志文章abstract::In this paper, the 3D-morphology of the porosity in dentin is investigated within the first 350μm from the dentin-enamel junction (DEJ) by fluorescence confocal laser scanning microscopy (CLSM). We found that the porous microstructure exhibits a much more complex geometry than classically described, which may impact o...
journal_title:Acta biomaterialia
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journal_title:Acta biomaterialia
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abstract:BACKGROUND:Avascular necrosis of bone (AVN) leads to sclerosis and collapse of bone and joints. The standard of care, vascularized bone grafts, is limited by donor site morbidity and restricted availability. The aim of this study was to generate and test engineered, axially vascularized SVF cells-based bone substitutes...
journal_title:Acta biomaterialia
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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journal_title:Acta biomaterialia
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journal_title:Acta biomaterialia
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更新日期:2021-01-15 00:00:00
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pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Acta biomaterialia
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更新日期:2018-12-01 00:00:00
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journal_title:Acta biomaterialia
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更新日期:2017-02-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2012.01.030
更新日期:2012-07-01 00:00:00
abstract:UNLABELLED:Given the wide spread clinical use of ceramic-based bone void fillers, we sought to determine the efficacy of an FDA-approved β-tricalcium phosphate bone graft substitute (JAX™) in combination with a carboxymethyl cellulose (CMC) handling agent that included a particular heparan glycosaminoglycan (GAG) varia...
journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2015.09.008
更新日期:2015-12-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2009.03.002
更新日期:2009-07-01 00:00:00
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journal_title:Acta biomaterialia
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journal_title:Acta biomaterialia
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2018-01-15 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Acta biomaterialia
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更新日期:2012-12-01 00:00:00
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更新日期:2020-04-15 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章,评审
doi:10.1016/j.actbio.2014.01.028
更新日期:2014-05-01 00:00:00
abstract::A pH-sensitive copolymer PAsp(DIP)-b-PAsp(MEA) (PDPM) was synthesized and self-assembled to micelle loading chemotherapeutic drug doxorubicin (DOX) and introducing a gold nanocage structure for photothermo-chemotherapy and photoacoustic imaging. After further surface modification with polyethylene glycol (PEG), the DO...
journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2017.10.018
更新日期:2017-12-01 00:00:00